Structural and Functional Aspects of Mammalian Hox Genes

A gene complex controlling segmentation in Drosophila

1978 • 3,668 citations

Retinoic Acid Embryopathy

1985 • 1,921 citations

Epithelial-Mesenchymal Interactions

1967 • 1,218 citations

The proximo‐distal sequence of origin of the parts of the chick wing and the role of the ectoderm

1948 • 1,101 citations

A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes

1984 • 1,066 citations

The murine and Drosophila homeobox gene complexes have common features of organization and expression

1989 • 1,021 citations

Neural Crest and the Origin of Vertebrates: A New Head

1983 • 1,011 citations

Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid

1991 • 1,007 citations

Identification and spatial distribution of retinoids in the developing chick limb bud

1987 • 964 citations

The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes.

1989 • 912 citations

Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development

1990 • 896 citations

Retinoic acid causes an anteroposterior transformation in the developing central nervous system

1989 • 885 citations

The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain

1991 • 882 citations

Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5

1991 • 856 citations

The proline-rich transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain

1989 • 781 citations

Structural relationships among genes that control development: sequence homology between the Antennapedia, Ultrabithorax, and fushi tarazu loci of Drosophila.

1984 • 776 citations

Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression

1991 • 698 citations

Segmentation in the chick embryo hindbrain is defined by cell lineage restrictions

1990 • 685 citations

Local application of retinoic acid to the limb bond mimics the action of the polarizing region

1982 • 669 citations

Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A

1990 • 660 citations

Molecular Genetics of the Bithorax Complex in Drosophila melanogaster

1983 • 616 citations

Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation

1989 • 612 citations

Positional signalling and specification of digits in chick limb morphogenesis

1975 • 588 citations

Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain

1989 • 566 citations

Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox geneHox-#150;1.6

1992 • 537 citations

Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells

1990 • 524 citations

Segment-specific expression of a zinc-finger gene in the developing nervous system of the mouse

1989 • 511 citations

A distinct Hox code for the branchial region of the vertebrate head

1991 • 503 citations

Structure of the segmentation gene paired and the Drosophila PRD gene set as part of a gene network

1986 • 496 citations

Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland

1990 • 479 citations

Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development.

1990 • 458 citations

Transcription factors that activate the Ultrabithorax promoter in developmentally staged extracts

1988 • 454 citations

A gene encoding a protein with zinc fingers is activated during G0/G1 transition in cultured cells.

1988 • 428 citations

Retinoids, homeoboxes, and growth factors: Toward molecular models for limb development

1991 • 410 citations

Teratogens and craniofacial malformations: relationships to cell death

1988 • 397 citations

Segmental distribution of bithorax complex proteins during Drosophila development

1985 • 397 citations

Expression of the homeobox Hox-4 genes and the specification of position in chick wing development

1991 • 394 citations

Variations of cervical vertebrate after expression of a Hox-1.1 transgene in mice

1990 • 371 citations

Identification of a retinoic acid-sensitive period during primary axis formation in Xenopus laevis.

1990 • 364 citations

Molecular and Genetic Organization of The Antennapedia Gene Complex of Drosophila melanogaster

1990 • 360 citations

The cellular basis of segmentation in the developing hindbrain

1990 • 358 citations

Murine genes related to the Drosophila AbdB homeotic genes are sequentially expressed during development of the posterior part of the body.

1991 • 344 citations

Cloning of an X. laevis gene expressed during early embryogenesis coding for a peptide region homologous to Drosophila homeotic genes

1984 • 335 citations

Expression of homeo box genes during mouse development: a review.

1988 • 331 citations

THE BITHORAX COMPLEX

1987 • 326 citations

Positional information revisited

1989 • 322 citations

The human HOX gene family

1989 • 317 citations

Homeobox gene expression correlated with the bifurcation process of limb cartilage development

1991 • 317 citations

Isolation of the mouse Hox-2.9 gene; analysis of embryonic expression suggests that positional information along the anterior-posterior axis is specified by mesoderm

1990 • 300 citations

Polarizing activity and retinoid synthesis in the floor plate of the neural tube

1990 • 292 citations

HOX-4 genes and the morphogenesis of mammalian genitalia.

1991 • 292 citations

Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain

1992 • 291 citations

Differential regulation by retinoic acid of the homeobox genes of the four HOX loci in human embryonal carcinoma cells

1991 • 291 citations

Multiple spatially specific enhancers are required to reconstruct the pattern of Hox-2.6 gene expression.

1991 • 286 citations

Genomic and cDNA clones of the homeotic locus Antennapedia in Drosophila.

1983 • 282 citations

A mouse gene related to Distal-less shows a restricted expression in the developing forebrain

1991 • 273 citations

Interaction between peptide growth factors and homoeobox genes in the establishment of antero-posterior polarity in frog embryos

1989 • 264 citations

Craniofacial abnormalities induced by ectopic expression of the homeobox gene Hox-1.1 in transgenic mice

1989 • 262 citations

The development of the vertebrate limb

1980 • 254 citations

A homeobox-containing marker of posterior neural differentiation shows the importance of predetermination in neural induction

1987 • 250 citations

Effects of retinoic acid excess on expression of Hox-2.9 and Krox-20 and on morphological segmentation in the hindbrain of mouse embryos.

1991 • 247 citations

Patterning the vertebrate head: murine Hox 2 genes mark distinct subpopulations of premigratory and migrating cranial neural crest

1991 • 246 citations

Spatially restricted domains of homeo-gene transcripts in mouse embryos: relation to a segmented body plan

1988 • 245 citations

Retinoic acid induces polarizing activity but is unlikely to be a morphogen in the chick limb bud

1991 • 242 citations

STAGES IN THE ORIGIN OF VERTEBRATES: ANALYSIS BY MEANS OF SCENARIOS

1989 • 242 citations

Expression of the mouse labial-Alike homeobox-containing genes, Hox 2.9 and Hox 1.6, during segmentation of the hindbrain

1991 • 239 citations

Expression of the homeo box-containing gene En-2 delineates a specific region of the developing mouse brain.

1988 • 225 citations

Involvement of the Chox-4 chicken homeobox genes in determination of anteroposterior axial polarity during limb development

1991 • 223 citations

The biological effects of XTC-MIF: quantitative comparison with Xenopus bFGF

1990 • 220 citations

Early retinoic acid-induced F9 teratocarcinoma stem cell gene ERA-1: alternate splicing creates transcripts for a homeobox-containing protein and one lacking the homeobox.

1988 • 219 citations

Conversion by retinoic acid of anterior cells into ZPA cells in the chick wing bud

1991 • 218 citations

Segment-specific expression of a homoeobox-containing gene in the mouse hindbrain

1989 • 214 citations

Two steps in the evolution of Antennapedia-class vertebrate homeobox genes.

1989 • 212 citations

Transgenic mice overexpressing the mouse homoeobox-containing gene Hox-1.4 exhibit abnormal gut development

1989 • 211 citations

HOX gene activation by retinoic acid

1991 • 211 citations

Isolation and characterization of a novel cDNA clone encoding a homeodomain that is developmentally regulated in the ventral forebrain

1991 • 209 citations

Retinoic acid modifies the pattern of cell differentiation in the central nervous system of neurula stage Xenopus embryos

1991 • 204 citations

Spatial restriction in expression of a mouse homoeo box locus within the central nervous system

1986 • 203 citations

Differential activation of Xenopus homeo box genes by mesoderm-inducing growth factors and retinoic acid.

1990 • 199 citations

Mouse homeo-genes within a subfamily, Hox-1.4, -2.6 and -5.1, display similar anteroposterior domains of expression in the embryo, but show stage- and tissue-dependent differences in their regulation

1989 • 192 citations

The segment-specific gene Krox-20 encodes a transcription factor with binding sites in the promoter region of the Hox-1.4 gene.

1990 • 190 citations

The bithorax complex: control of segmental identity

1987 • 188 citations

Differential and stage-related expression in embryonic tissues of a new human homoeobox gene

1986 • 182 citations

Two gene members of the murine HOX-5 complex show regional and cell-type specific expression in developing limbs and gonads.

1989 • 176 citations

An early effect of retinoic acid: cloning of an mRNA (Era-1) exhibiting rapid and protein synthesis-independent induction during teratocarcinoma stem cell differentiation.

1988 • 176 citations

The vertebrate limb: A model system to study the Hox/hom gene network during development and evolution

1992 • 175 citations

Homeobox gene expression plus autocrine growth factor production elicits myeloid leukemia.

1990 • 174 citations

Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages.

1988 • 172 citations

Clustered homeo boxes are differentially expressed during murine development

1985 • 171 citations

A deficiency of the homeotic complex of the beetle Tribolium

1991 • 157 citations

Homeo box gene complex on mouse chromosome 11: Molecular cloning, expression in embryogenesis, and homology to a human homeo box locus

1985 • 153 citations

Mouse homeobox gene transcripts occupy different but overlapping domains in embryonic germ layers and organs: a comparison of Hox-3.1 and Hox-1.5

1988 • 152 citations

Hox-5.1 defines a homeobox-containing gene locus on mouse chromosome 2.

1988 • 151 citations

DNA rearrangement of a homeobox gene in myeloid leukaemic cells.

1988 • 148 citations

Characterization of a murine homeo box gene, Hox-2.6, related to the Drosophila Deformed gene.

1988 • 146 citations

A gene with sequence similarity to Drosophila engrailed is expressed during the development of the neural tube and vertebrae in the mouse

1988 • 144 citations

Expression of a homeo domain protein in noncontact-inhibited cultured cells and postmitotic neurons.

1987 • 143 citations

The Hox-1.3 homeo box protein is a sequence-specific DNA-binding phosphoprotein.

1989 • 139 citations

Homoeobox gene Hox-1.5 expression in mouse embryos: earliest detection by in situ hybridization is during gastrulation

1987 • 137 citations

The Hox-4.8 gene is localized at the 5′ extremity of the Hox-4 complex and is expressed in the most posterior parts of the body during development

1991 • 135 citations

Interference with function of a homeobox gene in Xenopus embryos produces malformations of the anterior spinal cord

1989 • 134 citations

A new homeo-box is present in overlapping cosmid clones which define the mouse Hox-1 locus.

1986 • 134 citations

Embryonic expression and nuclear localization of Xenopus homeobox (Xhox) gene products.

1986 • 133 citations

Homeobox genes and models for patterning the hindbrain and branchial arches

1991 • 130 citations

Specific expression of the Hox 1.3 homeo box gene in murine embryonic structures originating from or induced by the mesoderm.

1987 • 130 citations

HOX4 genes encode transcription factors with potential auto- and cross-regulatory capacities.

1991 • 130 citations

Duplication of large genomic regions during the evolution of vertebrate homeobox genes.

1989 • 129 citations

Differential utilization of the same reading frame in a Xenopus homeobox gene encodes two related proteins sharing the same DNA-binding specificity.

1988 • 129 citations

Spatially restricted expression of a member of a new family of murine Distal-less homeobox genes in the developing forebrain.

1991 • 128 citations

A homoeotic gene cluster in the red flour beetle

1987 • 127 citations

Organization of human homeobox genes

1988 • 127 citations

Spatially restricted patterns of expression of the homeobox-containing gene Hox 2.1. during mouse embryogenesis

1988 • 126 citations

Homoeobox gene expression in mouse embryos varies with position by the primitive streak stage

1986 • 126 citations

Analysis of the murine Hox-2.7 gene: conserved alternative transcripts with differential distributions in the nervous system and the potential for shared regulatory regions.

1992 • 123 citations

Differential antero-posterior expression of two proteins encoded by a homeobox gene in Xenopus and mouse embryos.

1988 • 121 citations

The expression of murine Hox-2 genes id dependent on the differenation pathway and displays a collinear sensitivity to retinoic acid in F9 cels andXenopusembroys

1991 • 119 citations

Hox-1.6: a mouse homeo-box-containing gene member of the Hox-1 complex.

1987 • 119 citations

Primary structure and developmental expression pattern of Hox 3.1, a member of the murine Hox 3 homeobox gene cluster.

1988 • 119 citations

The murine Hox-2 genes display dynamic dorsoventral patterns of expression during central nervous system development

1991 • 118 citations

Patterning in the vertebrate limb

1991 • 114 citations

Spatial regulation of homeobox gene fusions in the embryonic central nervous system of transgenic mice

1988 • 113 citations

Isolation of a mouse cDNA coding for a developmentally regulated, testis-specific transcript containing homeo box homology.

1986 • 111 citations

Sequential expression of murine homeo box genes during F9 EC cell differentiation.

1986 • 108 citations

Region-specific expression in early chick and mouse embryos of Ghox-lab and Hox 1.6, vertebrate homeobox-containing genes related to Drosophila labial

1990 • 108 citations

Expression of a homeobox gene in the chick wing bud following application of retinoic acid and grafts of polarizing region tissue.

1990 • 106 citations

Differential expression of the mouse homeobox-containing gene Hox-1.4 during male germ cell differentiation and embryonic development.

1987 • 106 citations

At least three human homeoboxes on chromosome 12 belong to the same transcription unit

1988 • 105 citations

Separate elements cause lineage restriction and specify boundaries of Hox-1·1 expression

1991 • 105 citations

Molecular structure and spatial expression of a homeobox gene from the labial region of the Antennapedia-complex.

1988 • 104 citations

The mouse Hox-1.4 gene: primary structure, evidence for promoter activity and expression during development

1989 • 100 citations

Interaction between the proximo-distal and antero-posterior co-ordinates of positional value during the specification of positional information in the early development of the chick limb-bud

1974 • 99 citations

Mouse Hox-3.4: homeobox sequence and embryonic expression patterns compared with other members of the Hox gene network

1990 • 98 citations

Position dependent expression of a homeobox gene transcript in relation to amphibian limb regeneration.

1988 • 94 citations

Expression patterns of mouse hox genes: Clues to an understanding of developmental and evolutionary strategies

1991 • 92 citations

Determination of axial polarity in the vertebrate embryo: Homeodomain proteins and homeogenetic induction

1989 • 91 citations

Sequence analysis of the murine Hox-2.2, −2.3, and −2.4 homeo boxes: Evolutionary and structural comparisons

1987 • 91 citations

Anterior boundaries of Hox gene expression in mesoderm-derived structures correlate with the linear gene order along the chromosome

1989 • 91 citations

Overexpression of a homeodomain protein confers axis-forming activity to uncommitted xenopus embryonic cells

1991 • 88 citations

Complementary homeo protein gradients in developing limb buds.

1989 • 88 citations

The upstream region of the human homeobox gene HOX3D is a target for regulation by retinoic acid and HOX homeoproteins.

1992 • 85 citations

Primary structure and embryonic expression pattern of the mouse Hox-4.3* homeobox gene

1990 • 80 citations

Region-specific enhancers near two mammalian homeo box genes define adjacent rostrocaudal domains in the central nervous system.

1990 • 76 citations

The homeo domain of a murine protein binds 5' to its own homeo box.

1986 • 74 citations

Structure and expression pattern of the murine Hox-3.2 gene

1990 • 73 citations

Cellular Mechanisms of Pattern Formation in the Developing Limb

1991 • 73 citations

EVX2, a human homeobox gene homologous to the even-skipped segmentation gene, is localized at the 5′ end of HOX4 locus on chromosome 2

1991 • 72 citations

Differential expression of the homeobox gene Hox-1.3 in F9 embryonal carcinoma cells.

1988 • 72 citations

Nematode homeobox cluster

1991 • 71 citations

Position-specific activity of the Hox1.1 promoter in transgenic mice

1990 • 69 citations

Phylogenetic distribution of Antennapedia-like homoeo boxes

1986 • 68 citations

Position-specific activity of the Hox 1.1 promoter in transgenic mice

1990 • 67 citations

Abundant expression of homeobox genes in mouse embryonal carcinoma cells correlates with chemically induced differentiation.

1987 • 66 citations

Comparison of mouse and human HOX-4 complexes defines conserved sequences involved in the regulation of Hox-4.4.

1992 • 65 citations

A mouse homeobox containing gene on chromosome 11: sequence and tissue-specific expression

1987 • 62 citations

Identification and expression of a regeneration-specific homeobox gene in the newt limb blastema

1991 • 62 citations

Expression of the murine homeobox-containing gene Hox-2.3 suggests multiple time-dependent and tissue-specific roles during development

1990 • 55 citations

The developmental expression pattern of a new murine homeo box gene: Hox-2.5

1989 • 53 citations

Homeo Box Sequences of the Antennapedia Class Are Conserved Only in Higher Animal Genomes

1985 • 53 citations

The HOX-5 and surfeit gene clusters are linked in the proximal portion of mouse chromosome 2

1990 • 48 citations

Molecular mechanisms underlying the expression of the human HOX-5.1 gene

1990 • 47 citations

Hox-4 gene expression in mouse/chicken heterospecific grafts of signalling regions to limb buds reveals similarities in patterning mechanisms

1992 • 45 citations

Mesoderm-inducing factors and Spemann’s organiser phenomenon in amphibian development

1989 • 45 citations

Xenopushomeobox-containing cDNAs expressed in early development

1988 • 42 citations

Differential expression of Hox 3.1 protein in subregions of the embryonic and adult spinal cord

1990 • 41 citations

The zebrafish homeobox gene hox-2.2: transcription unit, potential regulatory regions and in situ localization of transcripts.

1990 • 41 citations

Expression of Hox-4 genes in the chick wing links pattern formation to the epithelial-mesenchymal interactions that mediate growth.

1992 • 41 citations

Deletion of a homeobox gene in myeloid leukemias with a deletion in chromosome 2

1988 • 38 citations

Stage- and tissue-specific expression of two homeo box genes in sea urchin embryos and adults

1988 • 38 citations

Mammalian homeobox-containing genes: genome organization, structure, expression and evolution.

1988 • 37 citations

A chicken homeo box gene with developmentally regulated expression

1989 • 37 citations

Structural analysis of the Hox-3.1 transcription unit and the Hox-3.2--Hox-3.1 intergenic region.

1990 • 36 citations

Expression of HOX homeogenes in human neuroblastoma cell culture lines

1990 • 36 citations

Specific DNA binding of the two chickenDeformedfamily homeodomain proteins,Chox-1.4 andChox-a

1990 • 32 citations

The three most downstream genes of the Hox-3 cluster are expressed in human extraembryonic tissues including trophoblast of androgenetic origin

1990 • 28 citations

Characterization of the murine Hox-2.3 promoter: involvement of the transcription factor USF (MLTF)

1991 • 24 citations

Characterisation of the murine Hox-3.3 gene and its promoter

1991 • 23 citations

The murine genes Hox-5.1 and Hox-4.1 belong to the same HOX complex on chromosome 2

1990 • 23 citations

Quox-1, a quail homeobox gene expressed in the embryonic central nervous system, including the forebrain.

1991 • 19 citations

A phylogenetic interpretation of the patterns of gene expression in Drosophila embryos

1988 • 18 citations