Chimeric receptors indicate that phenylalanine 39 is a major contributor to insulin specificity of the insulin receptor

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

1985 • 1,485 citations

Gene Splicing by Overlap Extension: Tailor-Made Genes Using the Polymerase Chain Reaction

2013 • 1,306 citations

Signal transmission by the insulin-like growth factors

1989 • 380 citations

Molecular analysis of signal transduction by growth factors

1988 • 224 citations

Different binding epitopes on the NK1 receptor for substance P and a non-peptide antagonist

1993 • 213 citations

A single amino acid of the cholecystokinin-B/gastrin receptor determines specificity for non-peptide antagonists

1993 • 211 citations

Amino–aromatic interaction between histidine 197 of the neurokinin-1 receptor and CP 96345

1993 • 185 citations

Insulin and insulin-like growth factor-1 binding specificity is determined by distinct regions of their cognate receptors.

1991 • 146 citations

The ligand specificities of the insulin receptor and the insulin-like growth factor I receptor reside in different regions of a common binding site.

1991 • 138 citations

Role of the Phenylalanine B24 Side Chain in Directing Insulin Interaction with Its Receptor

1989 • 116 citations

Importance of the character and configuration of residues B24, B25, and B26 in insulin-receptor interactions

1991 • 116 citations

The cysteine-rich domains of the insulin and insulin-like growth factor I receptors are primary determinants of hormone binding specificity. Evidence from receptor chimeras.

1990 • 104 citations

Substitution of lysine for asparagine at position 15 in the alpha-subunit of the human insulin receptor. A mutation that impairs transport of receptors to the cell surface and decreases the affinity of insulin binding.

1990 • 88 citations

A region of the insulin receptor important for ligand binding (residues 450-601) is recognized by patients' autoimmune antibodies and inhibitory monoclonal antibodies.

1991 • 85 citations

Hormone Binding Site of the Insulin Receptor: Analysis Using Photoaffinity-Mediated Avidin Complexing

1989 • 81 citations

Identification of determinants that confer ligand specificity on the insulin receptor.

1992 • 81 citations

Isolation of a proteolytically derived domain of the insulin receptor containing the major site of cross-linking/binding

1989 • 80 citations

Identification of a Ligand-Binding Region of the Human Insulin Receptor Encoded by the Second Exon of the Gene

1990 • 79 citations

Binding properties of chimeric insulin receptors containing the cysteine-rich domain of either the insulin-like growth factor I receptor or the insulin receptor related receptor

1991 • 76 citations

Localization of the insulin-binding site to the cysteine-rich region of the insulin receptor α-subunit

1988 • 71 citations

Changing the insulin receptor to possess insulin-like growth factor I ligand specificity

1990 • 70 citations

Insulin : its receptor and diabetes

1985 • 41 citations

Mutation of the High Cysteine Region of the Human Insulin Receptor α-Subunit Increases Insulin Receptor Binding Affinity and Transmembrane Signaling

1989 • 36 citations

Identification and characterization of the ligand-binding domain of insulin receptor by use of an anti-peptide antiserum against amino acid sequence 241-251 of the .alpha. subunit

1991 • 34 citations