Oxidant Signaling in Vascular Cell Growth, Death, and Survival

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

NAD(P)H Oxidase

2000 • 2,902 citations

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

1995 • 2,505 citations

Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)

1996 • 2,163 citations

Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway

1998 • 1,963 citations

Vitamin E Supplementation and Cardiovascular Events in High-Risk Patients

2000 • 1,945 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

Cell transformation by the superoxide-generating oxidase Mox1

1999 • 1,457 citations

Mechanisms and consequences of activation of protein kinase B/Akt

1998 • 1,305 citations

Sounding the Alarm: Protein Kinase Cascades Activated by Stress and Inflammation

1996 • 1,099 citations

Protein Tyrosine Phosphatases: A Diverse Family of Intracellular and Transmembrane Enzymes

1991 • 973 citations

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

1991 • 961 citations

Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav

1998 • 798 citations

Hypertension and the Pathogenesis of Atherosclerosis

1995 • 760 citations

Potential Role of Human Cytomegalovirus and p53 Interaction in Coronary Restenosis

1994 • 750 citations

p38 Mitogen-activated Protein Kinase Is a Critical Component of the Redox-sensitive Signaling Pathways Activated by Angiotensin II

1998 • 657 citations

Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression.

1992 • 653 citations

Nuclear Factor (NF)-κB–regulated X-chromosome–linked iap Gene Expression Protects Endothelial Cells from Tumor Necrosis Factor α–induced Apoptosis

1998 • 643 citations

Role of NADH/NADPH Oxidase–Derived H ₂ O ₂ in Angiotensin II–Induced Vascular Hypertrophy

1998 • 616 citations

Apoptotic Vascular Endothelial Cells Become Procoagulant

1997 • 612 citations

Reactive oxygen species are downstream mediators of p53-dependent apoptosis.

1996 • 590 citations

Randomised trial of α-tocopherol and β-carotene supplements on incidence of major coronary events in men with previous myocardial infarction

1997 • 578 citations

Reactive Oxygen Species Mediate the Activation of Akt/Protein Kinase B by Angiotensin II in Vascular Smooth Muscle Cells

1999 • 563 citations

Akt Mediates Cytoprotection of Endothelial Cells by Vascular Endothelial Growth Factor in an Anchorage-dependent Manner

1999 • 557 citations

Endothelial nuclear factor-kappa B and the initiation of the atherosclerotic lesion.

1993 • 525 citations

Apoptosis: Activate NF-κB or die?

1997 • 524 citations

NF-κB Mediates αvβ3 Integrin-induced Endothelial Cell Survival

1998 • 484 citations

Angiotensin Induces Inflammatory Activation of Human Vascular Smooth Muscle Cells

1999 • 483 citations

Enzymic mechanisms of superoxide production

1991 • 475 citations

Expression of phagocyte NADPH oxidase components in human endothelial cells

1996 • 432 citations

Fluid Shear Stress Stimulates Phosphorylation of Akt in Human Endothelial Cells

1998 • 420 citations

Differential Activation of Mitogen-Activated Protein Kinases by H ₂ O ₂ and O ₂ ⁻ in Vascular Smooth Muscle Cells

1995 • 416 citations

A Role for p38MAPK/HSP27 Pathway in Smooth Muscle Cell Migration

1999 • 401 citations

VEGF Prevents Apoptosis of Human Microvascular Endothelial Cells via Opposing Effects on MAPK/ERK and SAPK/JNK Signaling

1999 • 374 citations

Oxidized Low-Density Lipoprotein Induces Apoptosis of Human Endothelial Cells by Activation of CPP32-Like Proteases

1997 • 373 citations

Angiotensin II Induces Apoptosis of Human Endothelial Cells

1997 • 363 citations

rac1 Regulates a Cytokine-Stimulated, Redox-Dependent Pathway Necessary for NF-κB Activation

1996 • 337 citations

Stimulation of a Vascular Smooth Muscle Cell NAD(P)H Oxidase by Thrombin

1999 • 332 citations

Differential Effect of Hydrogen Peroxide and Superoxide Anion on Apoptosis and Proliferation of Vascular Smooth Muscle Cells

1997 • 289 citations

Utilization of Distinct Signaling Pathways by Receptors for Vascular Endothelial Cell Growth Factor and Other Mitogens in the Induction of Endothelial Cell Proliferation

2000 • 285 citations

Selective inhibition of protein tyrosine phosphatase activities by H2O2 and vanadate In vitro

1992 • 273 citations

Redox Regulation of the Caspases during Apoptosis^a

1998 • 271 citations

O ₂ sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase

1999 • 266 citations

Induction of Apoptosis by Pyrrolidinedithiocarbamate and N-Acetylcysteine in Vascular Smooth Muscle Cells

1996 • 248 citations

A20 Blocks Endothelial Cell Activation through a NF-κB-dependent Mechanism

1996 • 248 citations

Morphology of the endothelium over atherosclerotic plaques in human coronary arteries.

1988 • 243 citations

Rac1 inhibits TNF‐α‐induced endothelial cell apoptosis: dual regulation by reactive oxygen species

2000 • 230 citations

REACTIVE OXYGEN INTERMEDIATES IN BIOCHEMISTRY

1986 • 229 citations

Overexpression of Human Catalase Inhibits Proliferation and Promotes Apoptosis in Vascular Smooth Muscle Cells

1999 • 214 citations

Generation of reactive oxygen intermediates, activation of NF-κB, and induction of apoptosis in human endothelial cells by glucose: role of nitric oxide synthase?

1999 • 213 citations

A Role for Reactive Oxygen Species in Endothelial Cell Anoikis

1999 • 195 citations

Reactive oxygen species induce apoptosis of vascular smooth muscle cell

1997 • 188 citations

Expression of a functional neutrophil-type NADPH oxidase in cultured rat coronary microvascular endothelial cells

1998 • 188 citations

Expression of a constitutive NF-kappa B-like activity is essential for proliferation of cultured bovine vascular smooth muscle cells.

1995 • 184 citations

Ox-LDL induces apoptosis in human coronary artery endothelial cells: role of PKC, PTK, bcl-2, and Fas

1998 • 178 citations

Suppression of Ras-Induced Apoptosis by the Rac GTPase

1999 • 177 citations

Hydrogen peroxide stimulates transcription of c-jun in vascular smooth muscle cells: role of arachidonic acid.

1993 • 123 citations

Cytochrome b-558 α-subunit cloning and expression in rat aortic smooth muscle cells

1995 • 110 citations

Response to Injury

1952 • 108 citations

The involvement of reactive oxygen species and arachidonic acid in α₁‐adrenoceptor‐induced smooth muscle cell proliferation and migration

1997 • 101 citations

Induction of apoptosis by high proinsulin and glucose in cultured human umbilical vein endothelial cells is mediated by reactive oxygen species

1998 • 97 citations

p38 Mitogen-activated protein kinase inhibition attenuates intercellular adhesion molecule–1 up-regulation on human pulmonary microvascular endothelial cells

1998 • 92 citations

c-Jun Triggers Apoptosis in Human Vascular Endothelial Cells

1999 • 92 citations

Atherogenic lipoproteins, oxidative stress, and cell death

1999 • 81 citations

NF-κB Activation Is Required for Human Endothelial Survival during Exposure to Tumor Necrosis Factor-α but Not to Interleukin-1β or Lipopolysaccharide

1999 • 80 citations

Proapoptotic effects of ANG II in human coronary artery endothelial cells: role of AT₁receptor and PKC activation

1999 • 79 citations

Histone-like transcription factors in eukaryotes

1997 • 54 citations