Methylenetetrahydrofolate Reductase Polymorphism, Plasma Folate, Homocysteine, and Risk of Myocardial Infarction in US Physicians

The Metabolic and Molecular Bases of Inherited Disease

1995 • 12,086 citations

A Quantitative Assessment of Plasma Homocysteine as a Risk Factor for Vascular Disease

1995 • 3,645 citations

Final Report on the Aspirin Component of the Ongoing Physicians' Health Study

1989 • 2,180 citations

Vitamin Status and Intake as Primary Determinants of Homocysteinemia in an Elderly Population

1993 • 1,920 citations

Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis.

1969 • 1,846 citations

A Prospective Study of Plasma Homocyst(e)ine and Risk of Myocardial Infarction in US Physicians

1992 • 1,686 citations

Relation Between Folate Status, a Common Mutation in Methylenetetrahydrofolate Reductase, and Plasma Homocysteine Concentrations

1996 • 1,423 citations

Association between Plasma Homocysteine Concentrations and Extracranial Carotid-Artery Stenosis

1995 • 1,244 citations

A Prospective Study of Cholesterol, Apolipoproteins, and the Risk of Myocardial Infarction

1991 • 1,184 citations

Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida

1995 • 870 citations

Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease.

1996 • 670 citations

Serum Total Homocysteine and Coronary Heart Disease

1995 • 668 citations

Thermolabile methylenetetrahydrofolate reductase: an inherited risk factor for coronary artery disease.

1991 • 615 citations

Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase.

1988 • 607 citations

The pathogenesis of homocysteinemia: interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine

1992 • 562 citations

Prevalence of hyperhomocyst(e)inemia in patients with peripheral arterial occlusive disease.

1989 • 510 citations

Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry.

1988 • 479 citations

Carotid artery intimal-medial wall thickening and plasma homocyst(e)ine in asymptomatic adults. The Atherosclerosis Risk in Communities Study.

1993 • 460 citations

Homocysteinemia due to folate deficiency

1987 • 423 citations

Impaired homocysteine metabolism in early-onset cerebral and peripheral occlusive arterial disease Effects of pyridoxine and folic acid treatment

1990 • 397 citations

Folic acid—an innocuous means to reduce plasma homocysteine

1988 • 368 citations

Plasma homocyst(e)ine levels in men with premature coronary artery disease

1990 • 304 citations

A prospective study of folate and vitamin B6 and risk of myocardial infarction in US physicians.

1996 • 274 citations

Hyperhomocyst(e)inemia. A common and easily reversible risk factor for occlusive atherosclerosis.

1990 • 266 citations

Hyperhomocysteinaemia in stroke: prevalence, cause, and relationships to type of stroke and stroke risk factors

1992 • 261 citations

Thermolabile defect of methylenetetrahydrofolate reductase in coronary artery disease.

1993 • 230 citations

Plasma homocysteine in acute myocardial infarction: homocysteine‐lowering effect of folic acid

1995 • 212 citations

Inherited disorders of folate transport and metabolism

1995 • 201 citations

Plasma homocyst(e)ine as a risk factor for early familial coronary artery disease

1994 • 180 citations

Thermolabile methylenetetrahydrofolate reductase in patients with coronary artery disease

1988 • 175 citations

Homocyst(e)inemia in daily practice

1990 • 135 citations

Intermediate hyperhomocysteinemia resulting from compound heterozygosity of methylenetetrahydrofolate reductase mutations.

1991 • 128 citations

Inhibition of EDTA of growth of Lactobacillus casei in the folate microbiological assay and its reversal by added manganese or iron

1990 • 104 citations

Measurement of total plasma cysteamine using high-performance liquid chromatography with electrochemical detection

1988 • 92 citations

Homocysteine in frozen plasma samples. A short cut to establish hyperhomocysteinaemia as a risk factor for arteriosclerosis?

1993 • 58 citations