Dopamine, the prefrontal cortex and schizophrenia

EVIDENCE FOR THE EXISTENCE OF MONOAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS SYSTEM. I. DEMONSTRATION OF MONOAMINES IN THE CELL BODIES OF BRAIN STEM NEURONS.

1964 • 5,110 citations

Implications of Normal Brain Development for the Pathogenesis of Schizophrenia

1987 • 3,683 citations

Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics

1990 • 2,630 citations

Effect of Chlorpromazine or Haloperidol on Formation of 3‐Methoxytyramine and Normetanephrine in Mouse Brain

1963 • 2,148 citations

The frontal lobes

1986 • 2,138 citations

Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine

1991 • 2,008 citations

Dopamine in schizophrenia: a review and reconceptualization

1991 • 1,963 citations

The projections of the ventral tegmental area and adjacent regions: A combined fluorescent retrograde tracer and immunofluorescence study in the rat

1982 • 1,693 citations

Modulation of memory fields by dopamine Dl receptors in prefrontal cortex

1995 • 1,600 citations

Cognitive Deficit Caused by Regional Depletion of Dopamine in Prefrontal Cortex of Rhesus Monkey

1979 • 1,496 citations

D1 Dopamine Receptors in Prefrontal Cortex: Involvement in Working Memory

1991 • 1,365 citations

Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1

1991 • 1,157 citations

Differential Effect of Stress on In Vivo Dopamine Release in Striatum, Nucleus Accumbens, and Medial Frontal Cortex

1989 • 1,107 citations

Selective activation of the mesocortical DA system by stress

1976 • 1,037 citations

Ventral tegmental (A10) system: neurobiology. 1. Anatomy and connectivity

1987 • 1,003 citations

Deficits in Small Interneurons in Prefrontal and Cingulate Cortices of Schizophrenic and Schizoaffective Patients

1991 • 889 citations

Abnormally High Neuronal Density in the Schizophrenic Cortex

1995 • 866 citations

Localization of dopamine D3 receptor mRNA in the rat brain using in situ hybridization histochemistry: comparison with dopamine D2 receptor mRNA

1991 • 859 citations

Quantitative autoradiographic localization of the D1 and D2 subtypes of dopamine receptors in rat brain

1986 • 742 citations

Two types of neurone in the rat ventral tegmental area and their synaptic inputs.

1992 • 682 citations

Evidence of dysfunction of a prefrontal-limbic network in schizophrenia: a magnetic resonance imaging and regional cerebral blood flow study of discordant monozygotic twins

1992 • 665 citations

Review: D1 dopamine receptor—the search for a function: A critical evaluation of the D1/D2 dopamine receptor classification and its functional implications

1987 • 664 citations

Physiological Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia

1988 • 602 citations

Dopaminergic innervation of the cerebral cortex: unexpected differences between rodents and primates

1991 • 584 citations

Dopamine D1 receptor mechanisms in the cognitive performance of young adult and aged monkeys

1994 • 574 citations

Effect of lesion of cortical dopamine terminals on subcortical dopamine receptors in rats

1980 • 544 citations

Quantitative Cytoarchitectural Studies of the Cerebral Cortex of Schizophrenics

1986 • 506 citations

Neuroleptics increase C-FOS expression in the forebrain: Contrasting effects of haloperidol and clozapine

1992 • 477 citations

D ₁ Dopamine Receptor Activation Required for Postsynaptic Expression of D ₂ Agonist Effects

1987 • 468 citations

Dopamine synaptic complex with pyramidal neurons in primate cerebral cortex.

1989 • 435 citations

Burst Firing in Dopamine Neurons Induced by N -Methyl-D-aspartate: Role of Electrogenic Sodium Pump

1992 • 433 citations

Differential effects of inescapable footshocks and of stimuli previously paired with inescapable footshocks on dopamine turnover in cortical and limbic areas of the rat

1982 • 424 citations

Acute Effects of Typical and Atypical Antipsychotic Drugs on the Release of Dopamine from Prefrontal Cortex, Nucleus Accumbens, and Striatum of the Rat: An In Vivo Microdialysis Study

1990 • 407 citations

Distribution of dopaminergic receptors in the primate cerebral cortex: Quantitative autoradiographic analysis using [3H]raclopride, [3H]spiperone and [3H]SCH23390

1991 • 396 citations

Catecholamine innervation of the human cerebral cortex as revealed by comparative immunohistochemistry of tyrosine hydroxylase and dopamine‐beta‐hydroxylase

1989 • 391 citations

Responses of midbrain dopamine neurons to behavioral trigger stimuli in the monkey

1986 • 382 citations

Dopaminergic modulation of impaired cognitive activation in the anterior cingulate cortex in schizophrenia

1995 • 374 citations

Footshock and conditioned stress increase 3, 4-dihydroxyphenylacetic acid (DOPAC) in the ventral tegmental area but not substantia nigra

1985 • 355 citations

A detailed mapping of dopamine D-2 receptors in rat central nervous system by autoradiography with [125I]iodosulpride

1987 • 353 citations

Stress and the Mesocorticolimbic Dopamine Systemsa

1988 • 337 citations

Regional and laminar density of the dopamine innervation in adult rat cerebral cortex

1987 • 335 citations

Elimination of cocaine-induced hyperactivity and dopamine-mediated neurophysiological effects in dopamine D1 receptor mutant mice

1994 • 334 citations

Regional distribution of monoamines in the cerebral cortex and subcortical structures of the rhesus monkey: concentrations and in vivo synthesis rates

1979 • 330 citations

The distribution of tyrosine hydroxylase-immunoreactive fibers in primate neocortex is widespread but regionally specific

1987 • 319 citations

Regulation of dopamine release by impulse flow and by autoreceptors as studied by in vivo voltammetry in the rat striatum

1985 • 317 citations

Overlap of dopaminergic, adrenergic, and serotoninergic receptors and complementarity of their subtypes in primate prefrontal cortex

1990 • 314 citations

Evidence for the absence of impulse-regulating somatodendritic and synthesis-modulating nerve terminal autoreceptors on subpopulations of mesocortical dopamine neurons

1984 • 312 citations

D1-like and D2-like dopamine receptors synergistically activate rotation and c-fos expression in the dopamine-depleted striatum in a rat model of Parkinson's disease

1992 • 300 citations

Stress-induced increase in 3,4-dihydroxyphenylacetic acid (DOPAC) levels in the cerebral cortex and in n. accumbens: Reversal by diazepam

1978 • 291 citations

The effect of amphetamine on regional cerebral blood flow during cognitive activation in schizophrenia

1991 • 287 citations

Autoradiographic distribution of the D1 agonist [3H]SKF 38393, in the rat brain and spinal cord. Comparison with the distribution of D2 dopamine receptors

1986 • 278 citations

Immunocytochemical localization of dopamine in the prefrontal cortex of the rat at the light and electron microscopical level

1987 • 276 citations

Regional and laminar distribution of the dopamine and serotonin innervation in the macaque cerebral cortex: A radioautographic study

1988 • 260 citations

Dopamine D1 receptors facilitate transmitter release

1993 • 260 citations

Dopamine D2 receptor mechanisms contribute to age-related cognitive decline: the effects of quinpirole on memory and motor performance in monkeys

1995 • 259 citations

Dopamine and norepinephrine innervated cells in the rat prefrontal cortex: Pharmacological differentiation using microiontophoretic techniques

1976 • 251 citations

Inhibitory effects of ventral tegmental area stimulation on the activity of prefrontal cortical neurons: Evidence for the involvement of both dopaminergic and GABAergic components

1992 • 240 citations

Firing properties of substantia nigra dopaminergic neurons in freely moving rats

1985 • 235 citations

Inhibitory influence of the mesocortical dopaminergic system on spontaneous activity or excitatory response induced from the thalamic mediodorsal nucleus in the rat medial prefrontal cortex

1984 • 228 citations

Differential regional development of tolerance to increase in dopamine turnover upon repeated neuroleptic administration

1977 • 212 citations

Heterogeneous Targets of Dopamine Synapses in Monkey Prefrontal Cortex Demonstrated by Serial Section Electron Microscopy: A Laminar Analysis Using the Silver-enhanced Diaminobenzidine Sulfide (SEDS) Immunolabeling Technique

1993 • 209 citations

Differential effects of chronic antipsychotic drug treatment on extracellular glutamate and dopamine concentrations

1994 • 203 citations

A10 dopamine neurons: Role of autoreceptors in determining firing rate and sensitivity to dopamine agonists

1984 • 203 citations

Effects of dopamine antagonists on neuronal activity related to a delayed response task in monkey prefrontal cortex

1990 • 203 citations

Collateralization of monoamine neurons: mesotelencephalic dopamine projections to caudate, septum, and frontal cortex

1981 • 199 citations

A morphometric study of the dopamine-containing cell groups in the mesencephalon of normals, Parkinson patients, and schizophrenics.

1983 • 197 citations

Mesocortical dopamine neurons. Lack of autoreceptors modulating dopamine synthesis.

1981 • 194 citations

Region‐specific distribution of catecholamine afferents in primate cerebral cortex: A fluorescence histochemical analysis

1984 • 185 citations

When Symptoms Persist: Choosing Among Alternative Somatic Treatments for Schizophrenia

1991 • 179 citations

Effect of noxious tail pinch on the discharge rate of mesocortical and mesolimbic dopamine neurons: selective activation of the mesocortical system

1989 • 166 citations

Pharmacological studies on stress-induced increase in frontal cortical dopamine metabolism in the rat.

1986 • 165 citations

New dopaminergic terminal fields in the motor, visual (area 18b) and retrosplenial cortex in the young and adult rat. Immunocytochemical and catecholamine histochemical analyses

1985 • 162 citations

Dopamine D2 receptors in the rat brain: autoradiographic visualization using a high-affinity selective agonist ligand

1987 • 155 citations

Ultrastructural features of dopamine axon terminals in the anteromedial and the suprarhinal cortex of adult rat

1988 • 155 citations

Light and electron microscopic characterization of dopamine‐immunoreactive axons in human cerebral cortex

1992 • 155 citations

[3H]SCH 23390 binding to D1 dopamine receptors in the basal ganglia of the cat and primate: Delineation of striosomal compartments and pallidal and nigral subdivisions

1988 • 154 citations

Differential effects of ascending neurons containing dopamine and noradrenaline in the control of spontaneous activity and of evoked responses in the rat prefrontal cortex

1988 • 149 citations

Ultrastructural Double-Labelling Study of Dopamine Terminals and GABA-Containing Neurons in Rat Anteromedial Cerebral Cortex

1990 • 148 citations

Topographic Organization of Ascending Dopaminergic Projectionsa

1988 • 134 citations

D-1 dopamine receptor stimulation enables the inhibition of nucleus accumbens neurons by a D-2 receptor agonist

1987 • 134 citations

Cognitive and behavioral effects of the coadministration of dextroamphetamine and haloperidol in schizophrenia

1991 • 133 citations

Systemic administration of amperozide, a new atypical antipsychotic drug, preferentially increases dopamine release in the rat medial prefrontal cortex

1994 • 126 citations

Molecular cloning and characterization of a high affinity dopamine receptor (D1 beta) and its pseudogene.

1991 • 125 citations

D1 dopamine receptor stimulation enables the postsynaptic, but not autoreceptor, effects of D2 dopamine agonists in nigrostriatal and mesoaccumbens dopamine systems

1989 • 124 citations

Autoradiographic localization of D1 and D2 dopamine receptors in the human brain

1988 • 124 citations

Unique response to antipsychotic drugs is due to absence of terminal autoreceptors in mesocortical dopamine neurones

1982 • 111 citations

Visualization of a dopamine D1 receptor mRNA in human and rat brain

1991 • 104 citations

Opposing effects of dopamine D2 receptor stimulation on the spontaneous and the electrically evoked release of [3H]gaba on rat prefrontal cortex slices

1991 • 103 citations

Dopamine metabolism in the mesolimbic and mesocortical dopaminergic systems after single or repeated administrations of neuroleptics

1976 • 100 citations

Localization of multiple dopamine receptor subtype mRNAs in human and monkey motor cortex and striatum

1992 • 100 citations

Mesocortical Dopaminergic Function and Human Cognition

1988 • 100 citations

Characterization and distribution of [125I]epidepride binding to dopamine D2 receptors in basal ganglia and cortex of human brain.

1991 • 99 citations

Inhibitory influence of the mesocortical dopaminergic neurons on their target cells: electrophysiological and pharmacological characterization.

1991 • 96 citations

Localisation and pharmacological characterisation of D-2 dopamine receptors in rat cerebral neocortex and cerebellum using [125I]iodosulpride

1985 • 95 citations

Difference in the reactivity of the mesocortical dopaminergic neurons to stress in the balb/c and C57 BL/6 mice

1979 • 94 citations

ON THE RELEVANCE OF PREFERENTIAL INCREASES OF MESOLIMBIC VERSUS STRIATAL DOPAMINE TURNOVER FOR THE PREDICTION OF ANTIPSYCHOTIC ACTIVITY OF PSYCHOTROPIC DRUGS

1976 • 85 citations

Mesostriatal projections from ventral tegmentum and dorsal raphe: Cells project ipsilaterally or contralaterally but not bilaterally

1982 • 79 citations

Differential effects of acute and chronic administration of haloperidol on homovanillic acid levels in discrete dopaminergic areas of rat brain

1983 • 78 citations

Postnatal ontogenesis of the dopaminergic innervation in the rat anterior cingulate cortex (Area 24). Immunocytochemical and catecholamine fluorescence histochemical analysis

1985 • 75 citations

Autoradiographic visualization of dopamine D-2 receptors in the monkey brain using the selective benzamide drug [3H]raclopride

1986 • 73 citations

The effect of apomorphine on regional cerebral blood flow in schizophrenia

1989 • 71 citations

DARPP‐32, a phosphoprotein enriched in dopaminoceptive neurons bearing dopamine D1 receptors: DIstribution in the cerebral cortex of the newborn and adult rhesus monkey

1990 • 71 citations

Distribution of dopamine D1, D2, and D5 receptor mRNAs in the monkey brain: ribonuclease protection assay analysis

1995 • 69 citations

Computer imaging and analysis of dopamine (D2) and serotonin (S2) binding sites in rat basal ganglia or neocortex labeled by [3H]spiroperidol.

1985 • 68 citations

Dopamine receptors in the rat brain: quantitative autoradiographic localization using [3H]sulpiride

1985 • 67 citations

Autoradiographic localization and quantification of dopamine D2 receptors in normal human brain with [3H]N-n-propylnorapomorphine

1986 • 67 citations

Differential effects of a two-minute open-field session on dopamine utilization in the frontal cortices of BALB/c and C57 BL/6 mice

1980 • 63 citations

The effects of clozapine and fluperlapine on the in vivo release and metabolism of dopamine in the striatum and in the prefrontal cortex of freely moving rats.

1989 • 59 citations

Dopamine Autoreceptors Modulate Dopamine Release from the Prefrontal Cortex

1986 • 58 citations

Chronic haloperidol or fluphenazine: effects on dopamine metabolism in brain, cerebrospinal fluid and plasma of Cercopithecus aethiops (vervet monkey).

1980 • 56 citations

A postmortem study of frontal cortical dopamine D1 receptors in schizophrenics, psychiatric controls, and normal controls

1996 • 53 citations

D-2 dopamine-receptors regulate the release of [3H]dopamine in rat cortical regions showing dopamine immunoreactive fibers

1987 • 51 citations

Dopamine neurons projecting to the medial prefrontal cortex possess release-modulating autoreceptors

1987 • 51 citations

Evidence for dopamine autoreceptors in mesocortical dopamine neurons

1984 • 49 citations

Efficacy of carbamazepine compared with other agents: a clinical practice survey.

1994 • 49 citations

A subpopulation of mesocortical dopamine neurons possesses autoreceptors

1984 • 47 citations

Homovanillic acid in caudate and pre-frontal cortex following acute and chronic neuroleptic administration

1986 • 45 citations

Demonstration of autoreceptors on dopamine neurons in different brain regions of rats treated with gammabutyrolactone

1983 • 44 citations

Dopamine autoreceptors modulate the in vivo release of dopamine in the frontal, cingulate and entorhinal cortices.

1987 • 43 citations

Double-Blind Controlled Study of L-Dopa Therapy in Schizophrenia

1975 • 41 citations

Synthesis rate of dopamine: Difference between corpus striatum and limbic system as a possible explanation of variations in reactions to drugs

1983 • 37 citations

Molecular cloning and expression of the rhesus macaque D1 dopamine receptor gene.

1992 • 37 citations

Acute and chronic effects of neuroleptics and acute effects of apomorphine and amphetamine on dopamine turnover in corpus striatum and substantia nigra of the rat brain

1980 • 35 citations

Influence of acute and chronic haloperidol treatment on dopamine metabolism in the rat caudate-putamen, prefrontal cortex and amygdala

1991 • 33 citations

The agranular insular cortex: a site of unusually high dopamine utilisation

1986 • 32 citations

Autoradiographic Evidence of [³H]SCH 23390 Binding Site; in Human Prefrontal Cortex (Brodmann's Area 9)

1987 • 32 citations

Expression of the dopamine D2 receptor gene in brain

1991 • 30 citations

Cis-flupentixol antagonism of the rat prefrontal cortex neuronal response to apomorphine and ventral tegmental area input

1987 • 25 citations

D-2 dopamine receptors in the frontal cortex of rat and human

1985 • 24 citations

Chronic haloperidol treatment with low doses may enhance the increase of homovanillic acid in rat brain

1989 • 22 citations

Axonal branching of ventral tegmental and raphe projections to the frontal cortex in the rat

1984 • 22 citations

Autoradiographic localisation of3H-apomorphine binding sites in rat brain

1985 • 13 citations

Release‐regulating dopamine autoreceptors in human cerebral cortex

1993 • 12 citations

Effect of temperature and ionic environment on the specific binding of 3H(—)sulpiride to membranes from different rat brain regions

1985 • 12 citations

[3H](−)Sulpiride binding in rat striatum, cortex and anterior pituitary : An improved assay

1987 • 12 citations

Pharmacology of Dopamine‐Induced Electrophysiological Responses in the Rat Prefrontal Cortex: D₁‐ or D₂‐Mediated?

1988 • 10 citations

The catecholaminergic innervation of the human entorhinal cortex: Comparisons of schizophrenics and controls

1995 • 9 citations

Deleted Work

1955 • 0 citations