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Review: D1 dopamine receptor—the search for a function: A critical evaluation of the D1/D2 dopamine receptor classification and its functional implications

Data up to Jan 2025

Published1987
Citations664
References409

Total Citations Per Year

Abstract

References (409)

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1980 • 717 citations

Selective 60HDA-induced destruction of mesolimbic dopamine neurons: Abolition of psychostimulant-induced locomotor activity in rats

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1976 • 651 citations

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1978 • 646 citations

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1983 • 627 citations

Differential Effects of Classical and Atypical Antipsychotic Drugs on A9 and A10 Dopamine Neurons

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Characterization of the binding of 3H-SCH 23390, a selective D-1 receptor antagonist ligand, in rat striatum

1984 • 566 citations

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Fiber Connections of the Basal Ganglia

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Pharmacological effects of a specific dopamine D-1 antagonist SCH 23390 in comparison with neuroleptics

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1984 • 351 citations

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1981 • 344 citations

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1986 • 341 citations

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1974 • 330 citations

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1980 • 326 citations

Obligatory D-1/D-2 receptor interaction in the generation of dopamine agonist related behaviors

1986 • 321 citations

Bromocriptine in Parkinsonism

1974 • 311 citations

Autoradiographic localization of D1 dopamine receptors in the rat brain with [3H]SCH 23390

1986 • 310 citations

Induction of depolarization block in midbrain dopamine neurons by repeated administration of haloperidol: analysis using in vivo intracellular recording.

1986 • 309 citations

Anterior pituitary dopamine receptors. Demonstration of interconvertible high and low affinity states of the D-2 dopamine receptor.

1982 • 295 citations

Stimulation by Dopamine of Adenylate Cyclase in Retinal Homogenates and of Adenosine-3′:5′-Cyclic Monophosphate Formation in Intact Retina

1972 • 286 citations

Behavioral differences between neonatal and adult 6-hydroxydopamine-treated rats to dopamine agonists: relevance to neurological symptoms in clinical syndromes with reduced brain dopamine.

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ADVANCES IN BEHAVIORAL BIOLOGY

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Dopamine inhibits adenylate cyclase in human prolactin-secreting pituitary adenomas

1979 • 271 citations

Intracellular studies on the dopamine-induced firing inhibition of neostriatal neurons in vitro: Evidence for D1 receptor involvement

1987 • 267 citations

Topographic projections of substance P and GABA pathways in the striato- and pallido-nigral system: A biochemical and immunohistochemical study

1978 • 264 citations

Effects of neuroleptics on 3H-haloperidol and 3H-CIS (Z)-flupenthixol binding and on adenylate cyclase activity in vitro

1978 • 261 citations

Studies on the pharmacological properties of dopamine receptors in various areas of the central nervous system.

1978 • 260 citations

Tolerance phenomena with neuroleptics catalepsy, apomorphine stereotypies and striatal dopamine metabolism in the rat after single and repeated administration of loxapine and haloperidol

1973 • 256 citations

Dopamine D-1 receptor agonists combined with the selective D-2 agonist quinpirole facilitate the expression of oral stereotyped behaviour in rats

1987 • 255 citations

Pharmacological characterization of the D2 dopamine receptor negatively coupled with adenylate cyclase in rat anterior pituitary.

1983 • 254 citations

Association with persistent neuroleptic-induced dyskinesia of regional changes in brain GABA synthesis

1984 • 252 citations

Dopamine receptors in brain and periphery

1987 • 251 citations

Induction of oral dyskinesias in naive rats by D1 stimulation

1983 • 250 citations

The D-1 dopamine receptor antagonist SCH 23390 also interacts potently with brain serotonin (5-HT2) receptors

1986 • 245 citations

The Action of Neuroleptic Drugs on Dopamine-Stimulated Adenosine Cyclic 3',5'-Monophosphate Production in Rat Neostriatum and Limbic Forebrain

1974 • 240 citations

Pharmacological Specificity of Conditioned Avoidance Response Inhibition in Rats: Inhibition by Neuroleptics and Correlation to Dopamine Receptor Blockade

1982 • 238 citations

Characterization of dopamine receptors mediating inhibition of adenylate cyclase activity in rat striatum.

1985 • 236 citations

Minireview A systematic study of the pharmacological activities of dopamine antagonists

1979 • 232 citations

3-PPP, a new centrally acting DA-receptor agonist with selectivity for autoreceptors

1981 • 229 citations

Schizophrenic Symptoms Improve with Apomorphine

1978 • 228 citations

Dopamine-Sensitive Adenylate Cyclase: Location in Substantia Nigra

1977 • 227 citations

Dopaminergic innervation of the globus pallidus by collaterals from the nigrostriatal pathway

1979 • 222 citations

Acute dystonia induced by neuroleptic drugs

1986 • 220 citations

Pharmacological characterization of dopamine autoreceptors in the rat ventral tegmental area: microiontophoretic studies.

1984 • 220 citations

Comparison of the effects of chronic haloperidol treatment on A9 and A10 dopamine neurons in the rat

1983 • 212 citations

Differential regional development of tolerance to increase in dopamine turnover upon repeated neuroleptic administration

1977 • 212 citations

Dopamine-receptor agonists: Mechanisms underlying autoreceptor selectivity

1985 • 209 citations

Neurobiological substrates of tardive dyskinesia: the GABA hypothesis

1984 • 209 citations

Apomorphine in Parkinson's disease.

1951 • 208 citations

Selective blockade of dopamine D-1 receptors by SCH 23390 discloses striatal dopamine D-2 receptors mediating the inhibition of adenylate cyclase in rats

1984 • 207 citations

Intravenous self-administration of dopamine receptor agonists by rhesus monkeys.

1984 • 203 citations

Dopamine receptors: Pharmacological and anatomical evidences indicate that two distinct dopamine receptor populations are present in rat striatum

1978 • 203 citations

Behavioural stimulation is induced by separate dopamine D-1 and D-2 receptor sites in reserpine-pretreated but not in normal rats

1985 • 202 citations

6-hydroxydopamine treatments enhance behavioral responses to intracerebral microinjection of D1- and D2-dopamine agonists into nucleus accumbens and striatum without changing dopamine antagonist binding.

1987 • 201 citations

Central dopamine receptor agonist and antagonist actions of the enantiomers of 3-PPP

1983 • 200 citations

Subcellular localization of dopamine-sensitive adenylate cyclase and dopamine receptor binding activities

1978 • 198 citations

Dopaminergic mechanisms and motor function: Characterization of D-1 and D-2 dopamine receptor interactions

1986 • 198 citations

Lisuride and Other Dopamine Agonists

1983 • 198 citations

Three classes of dopamine receptor (D-2, D-3, D-4) identified by binding studies with 3H-apomorphine and 3H-domperidone

1980 • 197 citations

Stimulation of both D1 and D2 dopamine receptors appears necessary for full expression of postsynaptic effects of dopamine agonists: a neurophysiological study

1987 • 193 citations

Electrophysiological evidence for the existence of both D-1 and D-2 dopamine receptors in the rat nucleus accumbens

1986 • 193 citations

Parametric analysis of brain stimulation reward in the rat: III. Effect of performance variables on the reward summation function.

1974 • 192 citations

Activation of dopamine receptors inhibits calcium-dependent glutamate release from cotico-striatal terminals in vitro

1980 • 189 citations

Behavioral correlations of dopamine receptor activation

1983 • 188 citations

Independent in vitro regulation by the D-2 dopamine receptor of dopamine-stimulated efflux of cyclic AMP and K+-stimulated release of acetylcholine from rat neostriatum

1982 • 184 citations

Selective stimulation of dopamine and noradrenaline autoreceptors by B-HT 920 and B-HT 933, respectively

1982 • 182 citations

Effects of the putative D-1 antagonist SCH 23390 on stereotyped behaviour induced by the D-2 agonist RU24213

1985 • 179 citations

Synergistic effects of D1 and D2 dopamine agonists on turning behaviour in rats

1986 • 178 citations

Catecholamines and self-stimulation: Reward and performance effects dissociated

1978 • 175 citations

Blockade of D-1 receptors by SCH 23390 antagonizes morphine- and amphetamine-induced place preference conditioning

1987 • 169 citations

Modulation of striatal [3H]-glutamic acid release by dopaminergic drugs

1980 • 169 citations

Quantitative autoradiography of dopamine D2 sites in rat caudate-putamen: Localization to intrinsic neurons and not to neocortical afferents

1987 • 165 citations

d-Amphetamine-induced depression of central dopamine neurons: Evidence for mediation by both autoreceptors and a striato-nigral feedback pathway

1978 • 165 citations

The yawning-penile erection syndrome as a model for putative dopamine autoreceptor activity

1984 • 163 citations

Nucleus accumbens to globus pallidus GABA projection subserving ambulatory activity

1980 • 162 citations

Changes in dopamine-mediated behaviour during one year's neuroleptic administration

1979 • 160 citations

Modulation by endogenous dopamine of the release of acetylcholine in the caudate nucleus of the rabbit

1980 • 159 citations

Dopamine receptor of the porcine anterior pituitary gland. Evidence for two affinity states discriminated by both agonists and antagonists.

1982 • 158 citations

SCH-23390: A selective D1 dopamine antagonist with potent D2 behavioral actions

1984 • 158 citations

Sniffing, rearing and locomotor responses to the D-1 dopamine agonist R-SK&F 38393 and to apomorphine: Differential interactions with the selective D-1 and D-2 antagonists SCH 23390 and metoclopramide

1985 • 158 citations

Dopamine Modulation of the Effects of γ-Aminobutyric Acid on Substantia Nigra Pars Reticulata Neurons

1983 • 158 citations

Presence of substance P and GABA in separate striatonigral neurons

1977 • 157 citations

Effects of D1 and D2 dopamine receptor stimulation on the activity of substantia nigra pars reticulata neurons in 6-hydroxydopamine lesioned rats: D1/D2 coactivation induces potentiated responses

1987 • 155 citations

Differential inhibition by dopamine D-1 and D-2 antagonists of circling behaviour induced by dopamine agonists in rats with unilateral 6-hydroxydopamine lesions

1984 • 153 citations

An analysis of chlorpromazine-induced suppression of the avoidance response

1962 • 153 citations

d -Amphetamine-Induced Inhibition of Central Dopaminergic Neurons: Mediation by a Striato-Nigral Feedback Pathway

1976 • 153 citations

Differential involvement of dopamine D-1 and D-2 receptors in the circling behaviour induced by apomorphine, SK & F 38393, pergolide and LY 171555 in 6-hydroxydopamine-lesioned rats

1985 • 152 citations

In vivo release of [3H]γ-aminobutyric acid in the rat neostriatum—II. Opposing effects of D1 and D2 dopamine receptor stimulation in the dorsal caudate putamen

1986 • 150 citations

Catalepsy induced by SCH 23390 in rats

1985 • 148 citations

Essays in neurochemistry and neuropharmacology

1979 • 148 citations

Localization of Nigral Dopamine-Sensitive Adenylate Cyclase on Neurons Originating from the Corpus Striatum

1977 • 147 citations

D2-dopamine receptor-mediated inhibition of cyclic AMP formation in striatal neurons in primary culture.

1985 • 143 citations

Hyperpolarizing and depolarizing actions of dopamine via D-1 and D-2 receptors on nucleus accumbens neurons

1986 • 143 citations

Dopamine agonist-induced locomotor activity in rats treated with 6-hydroxydopamine at differing ages: functional supersensitivity of D-1 dopamine receptors in neonatally lesioned rats.

1985 • 143 citations

Stimulation of D2-dopamine receptors in rat neostriatum inhibits the release of acetylcholine and dopamine but does not affect the release of γ-aminobutyric acid, glutamate or serotonin

1982 • 142 citations

A comparison between dopamine-stimulated adenylate cyclase and 3H-SCH 23390 binding in rat striatum

1985 • 141 citations

Behavioural correlates of the action of selective D-1 dopamine receptor antagonists

1986 • 141 citations

Further evidence for the involvement of D2, but not D1 dopamine receptors in dopaminergic control of striatal cholinergic transmission

1982 • 141 citations

The D2-dopamine receptor of anterior pituitary is functionally associated with a pertussis toxin-sensitive guanine nucleotide binding protein.

1987 • 140 citations

Evidence that D-1 dopamine receptors contribute to the supersensitive behavioral responses induced by L-dihydroxyphenylalanine in rats treated neonatally with 6-hydroxydopamine.

1985 • 140 citations

Reduction of nigral glutamic acid decarboxylase in rats with neuroleptic-induced oral dyskinesia

1983 • 140 citations

Dopaminergic Mechanisms in the Teleost Retina

1981 • 140 citations

Selective dopamine D2 receptor reduction enhances A D1 mediated oral dyskinesia in rats

1986 • 138 citations

Differential effects of dopamine D1 and D2 agonists and antagonists on velocity of movement, rearing and grooming in the mouse

1986 • 138 citations

The electrophysiology of dopamine (D2) receptors: A study of the actions of dopamine on corticostriatal transmission

1983 • 137 citations

Selective D-1 dopamine receptor agonist treatment of parkinson's disease

1987 • 136 citations

Behavioral and radioligand binding evidence for irreversible dopamine receptor blockade by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

1983 • 135 citations

D-1 dopamine receptor stimulation enables the inhibition of nucleus accumbens neurons by a D-2 receptor agonist

1987 • 134 citations

Opposite effects of a D1 and a D2 agonist on oral movements in rats

1987 • 134 citations

Relationship between receptor occupancy and response at striatal dopamine autoreceptors.

1987 • 133 citations

Dopamine receptor agonists: Mechanisms underlying autoreceptor selectivity II. Theoretical considerations

1985 • 131 citations

Effects of chronic SCH23390 treatment on the biochemical and behavioral properties of D1 and D2 dopamine receptors: potentiated behavioral responses to a D2 dopamine agonist after selective D1 dopamine receptor upregulation.

1986 • 131 citations

Stereotyped behaviour in response to the selective D-2 dopamine receptor agonist RU 24213 is enhanced by pretreatment with the selective D-1 agonist SK&F 38393

1986 • 130 citations

Dopamine receptor agonists: Intrinsic activity vs. state of receptor

1983 • 127 citations

Interaction of pergolide with central dopaminergic receptors.

1980 • 126 citations

Peripheral pre- and post-synaptic dopamine receptors: are they different from dopamine receptors in the central nervous system?

1979 • 125 citations

Diastolic properties of the hypertrophied left ventricle in spontaneously hypertensive rats

1983 • 125 citations

Selective D-1 dopamine receptor increase following chronic treatment with SCH 23390

1985 • 125 citations

Inactivation of D1 and D2 dopamine receptors by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline in vivo: selective protection by neuroleptics.

1985 • 125 citations

Dopaminergic inhibition of adenylate cyclase correlates with high affinity agonist binding to anterior pituitary D2 dopamine receptors

1984 • 125 citations

Activity of two new potent dopaminergic agonists at the striatal and anterior pituitary levels

1980 • 122 citations

Functional evidence for selective dopamine D-1 receptor blockade by SCH 23390

1984 • 121 citations

Resolution and absolute configuration of an ergoline-related dopamine agonist, trans-4,4a,5,6,7,8,8a,9-octahydro-5-propyl-1H(or 2H)-pyrazolo[3,4-g]quinoline

1983 • 121 citations

Bromocriptine induces marked locomotor stimulation in dopamine-depleted mice when D-1 dopamine receptors are stimulated with SKF38393

1986 • 121 citations

Further functional in vitro comparison of pre- and postsynaptic dopamine receptors in the rabbit caudate nucleus

1983 • 121 citations

Effects of lisuride and LSD on cerebral monoamine systems and hallucinosis

1978 • 120 citations

Peripheral dopamine receptors: A classification based on potency series and specific antagonism

1983 • 120 citations

Binding of [3H]SCH23390 in Rat Brain: Regional Distribution and Effects of Assay Conditions and GTP Suggest Interactions at a D1‐Like Dopamine Receptor

1985 • 116 citations

Loss of rat striatal dopamine receptors with ageing is selective for D-2 but not D-1 sites: Association with increased non-specific binding of the D-1 ligand [3H]piflutixol

1984 • 115 citations

Dopamine enhances terminal excitability of hippocampal-accumbens neurons via D2 receptor: role of dopamine in presynaptic inhibition

1986 • 115 citations

Guanine nucleotide regulation of agonist interactions at [3H]SCH23390-labeled D1 dopamine receptors in rat striatum

1986 • 115 citations

Extrapyramidal and mesolimbic involvement with the stereotypic activity of D- and L-amphetamine

1974 • 114 citations

The dopamine D2 agonist LY 141865, but not the D1 agonist SKF 38393, reverses parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the common marmoset

1985 • 113 citations

Antipsychotic drug effects on the electrical activity of dopaminergic neurons

1984 • 112 citations

Dopamine autoreceptors: pharmacology, function and comparison with post-synaptic dopamine receptors.

1979 • 111 citations

Neonatal-6-hydroxydopamine treatment: Model of susceptibility for self-mutilation in the lesch-nyhan syndrome

1984 • 107 citations

Effect of dopamine D-1 and D-2 receptor selective drugs on dopamine release and metabolism in rat striatum in vivo

1986 • 106 citations

5HT-receptor antagonist properties of SCH 23390 in vascular smooth muscle and brain

1984 • 105 citations

Peripheral dopamine receptors, potential targets for a new class of antihypertensive agents

1982 • 105 citations

Selective D2 dopamine receptor agonists prevent catalepsy induced by SCH 23390, a selective D1 antagonist

1985 • 105 citations

Evidence for Different States of the Dopamine Dl Receptor: Clozapine and Fluperlapine May Preferentially Label an Adenylate Cyclase‐Coupled State of the Dl Receptor

1986 • 104 citations

Antagonism of the amphetamine cue by both classical and atypical antipsychotic drugs

1985 • 103 citations

Picomolar affinity of 125I-SCH 23982 for D1 receptors in brain demonstrated with digital subtraction autoradiography

1987 • 103 citations

Selective binding of YM-09151-2, a new potent neuroleptic, to D2-dopaminergic receptors.

1983 • 103 citations

Dopaminergic stimulation of cyclic AMP accumulation and parathyroid hormone release from dispersed bovine parathyroid cells

1977 • 102 citations

Localization of D-2 dopamine receptors to intrinsic striatal neurones by quantitative autoradiography

1986 • 102 citations

Behavioural and pharmacological characterization of the mouth movements induced by muscarinic agonists in the rat

1986 • 102 citations

SCH-23390 antagonism of a D-2 dopamine agonist depends upon catecholaminergic neurons

1985 • 102 citations

Physiological Concentrations of Dopamine Decrease Adenosine 3′,5′-Monophosphate Levels in Cultured Rat Anterior Pituitary Cells and Enriched Populations of Lactotrophs: Evidence for a Causal Relationship to Inhibition of Prolactin Release*

1982 • 101 citations

Characterisation of the mechanisms by which purported dopamine agonists reduce spontaneous locomotor activity of mice

1981 • 100 citations

Coupling of Dopamine D 1 Recognition Sites with Adenylate Cyclase in Nuclei Accumbens and Caudatus of Schizophrenics

1983 • 99 citations

Some atypical neuroleptics inhibit [3H]SCH 23390 binding in vivo

1986 • 98 citations

Similarities between the binding of 3H-piflutixol and 3H-flupentixol to rat striatal dopamine receptors in vitro

1981 • 98 citations

Locomotor behaviors in response to new selective D-1 and D-2 dopamine receptor agonists, and the influence of selective antagonists

1986 • 97 citations

Dopamine and [D-ALA2, D-Leu5]enkephalin inhibit the electrically stimulated neurohypophyseal release of vasopressin in vitro: evidence for calcium-dependent opiate action

1982 • 96 citations

[3H]SCH 23390 binding sites increase after chronic blockade of D-1 dopamine receptors

1985 • 96 citations

Hyperactivity induced by stimulation of separate dopamine D-1 and D-2 receptors in rats with bilateral 6-OHDA lesions

1985 • 95 citations

Detection of dopamine receptors in the area postrema

1981 • 95 citations

Inhibition of inositol phospholipid breakdown by D2 dopamine receptors in dissociated bovine anterior pituitary cells

1985 • 95 citations

3H-SCH 23390 binding sites in the rat substantia nigra: Evidence for a presynaptic localization and innervation by dopamine

1986 • 93 citations

Interactions of novel dopaminergic ligands with D-1 and D-2 dopamine receptors

1982 • 93 citations

The D1 dopamine receptor antagonist, SCH 23390 reduces locomotor activity and rearing in rats

1985 • 93 citations

Permissive role of D-1 receptor stimulation by endogenous dopamine for the expression of postsynaptic D-2-mediated behavioural responses. Yawning in rats

1987 • 92 citations

Selective and stereospecific interactions of R-SK&F 38393 with [3H]piflutixol but not [3H]spiperone binding to striatal D1 and D2 dopamine receptors: Comparisons with SCH 23390

1984 • 92 citations

Dopamine receptor agonistic and antagonistic effects of 3-PPP enantiomers

1983 • 90 citations

Stimulation of a D-2 Dopamine Receptor in the Intermediate Lobe of the Rat Pituitary Gland Decreases the Responsiveness of the β-Adrenoceptor: Biochemical Mechanism

1981 • 88 citations

Separation of peripheral dopamine receptors by a selective DA1 antagonist, SCH 23390.

1984 • 86 citations

Pallidal and entopeduncular intracellular responses to striatal, cortical, thalamic, and sensory inputs

1974 • 86 citations

Bromocriptine in Parkinsonism: long-term treatment, dose response, and comparison with levodopa.

1976 • 85 citations

Antistereotypic effects of dopamine D-1 and D-2 antagonists after intrastriatal injection in rats. pharmacological and regional specificity

1985 • 85 citations

In vitro acetylcholine release from rat caudate nucleus as a new model for testing drugs with dopamine-receptor activity

1979 • 84 citations

Further evidence that 3H-cis(Z)flupenthixol binds to the adenylate cyclase-associated dopamine receptor (D-1) in rat corpus striatum

1980 • 84 citations

Neuropharmacology of Central Nervous System and Behavioral Disorders

1982 • 83 citations

Chronic neuroleptic treatment increases D-2 but not D-1 receptors in rat striatum

1985 • 83 citations

D-1 and D-2 dopamine receptor blockade: interactive effects in vitro and in vivo.

1986 • 83 citations

Effects of dopamine on spontaneous and evoked activity of caudate neurons

1983 • 82 citations

Intracellular studies of the corpus striatum II. Patterns of synaptic activities in lenticular and entopeduncular neurons

1967 • 81 citations

Reduction of the rewarding effect of brain stimulation by a blockade of dopamine D1 receptor with SCH 23390

1986 • 80 citations

Role of presynaptic dopamine receptors in regulation of the glutamatergic neurotransmission in rat neostriatum

1984 • 79 citations

In vivo release of [3H]γ-aminobutyric acid in the rat neostriatum—I. Characterization and topographical heterogeneity of the effects of dopaminergic and cholinergic agents

1986 • 78 citations

Dopamine, acting through D-2 receptors, inhibits rat striatal adenylate cyclase by a GTP-dependent process.

1986 • 78 citations

Opposing effects of D-1 and D-2 receptor antagonists on acetylcholine levels in the rat striatum

1986 • 78 citations

D-2 Dopamine Receptor-Mediated Inhibition of Adenylate Cyclase Activity in the Intermediate Lobe of the Rat Pituitary Gland Requires Guanosine 5'-Triphosphate

1982 • 78 citations

Sedation and sleep induced by high doses of apomorphine after blockade of D-1 receptors by SCH 23390

1985 • 77 citations

Dual action on central dopamine function of transdihydrolisuride, a 9, 10-dihydrogenated analogue of the ergot dopamine agonist lisuride

1983 • 76 citations

Studies on renal dopamine receptors with a new agonist

1978 • 73 citations

Endogenous dopamine can modulate inhibition of substantia nigra pars reticulata neurons elicited by GABA iontophoresis or striatal stimulation

1986 • 73 citations

Analysis of dopamine d1 and d2 receptor involvement in d- and l-amphetamine-induced anorexia in rats

1985 • 72 citations

[125I]SCH 23982: the ligand of choice for identifying the D-1 dopamine receptor

1986 • 71 citations

Dopaminergic modulation of evoked vasopressin release from the isolated neurohypophysis of the rat

1982 • 71 citations

Biochemical Identification of the β-Adrenoceptor and Evidence for the Involvement of an Adenosine 3′,5′-Monophosphate System in the β-Adrenergically Induced Release of a-Melanocyte-Stimulating Hormone in the Intermediate Lobe of the Rat Pituitary Gland

1980 • 71 citations

The dopaminergic innervation of the intermediate lobe and of the neural lobe of the pituitary gland.

1985 • 71 citations

Adrenergic Effect of Chronic Administration of Neuroleptics

1967 • 70 citations

Dopamine D2 receptors and dopamine metabolismRelationship between biochemical and behavioural effects of substituted benzamide drugs

1986 • 70 citations

Dopamine attenuates the effects of GABA on single unit activity in the Globus pallidus

1984 • 69 citations

Neurotransmitter interactions related to central dopamine neurons.

1978 • 69 citations

Agonist high- and low-affinity states of the D2-dopamine receptor in calf brain. Partial conversion by guanine nucleotide.

1984 • 68 citations

Behavioral Actions of Neuroleptics

1978 • 68 citations

Interactions of dopamine agonists with brain D1 receptors labeled by 3H-antagonists. Evidence for the presence of high and low affinity agonist-binding states.

1985 • 68 citations

Failure of SKF 38393‐A to relieve parkinsonian symptoms induced by 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine in the marmoset

1985 • 67 citations

N,N-disubstituted 2-aminotetralins are potent D-2 dopamine receptor agonists

1984 • 67 citations

Presynaptic dopaminergic control of high affinity glutamate uptake in the striatum

1983 • 67 citations

Neurophysiological evidence that D-1 dopamine receptor blockade attenuates postsynaptic but not autoreceptor-mediated effects of dopamine agonists

1986 • 67 citations

Preferential inhibition of ligand binding to calf striatal dopamine D1 receptors by SCH 23390

1983 • 66 citations

Dopamine receptor subtypes: In vivo biochemical evidence for functional interaction

1985 • 66 citations

An iodinated ligand identifying the D-1 dopamine receptor

1985 • 65 citations

D-2 receptor stimulation inhibits cyclic AMP formation brought about by D-1 receptor stimulation in rat neostriatum but not nucleus accumbens

1986 • 65 citations

Excitatory input from sensory motor cortex to neostriatum and its modification by conditioning stimulation of the substantia nigra

1984 • 63 citations

Dopamine autoreceptors and the effects of drugs on locomotion and dopamine synthesis

1985 • 63 citations

Non-specific supersensitivity of striatal dopamine receptors after 6-hydroxydopamine lesion of the nigrostriatal pathway

1976 • 62 citations

The dopamine receptor in the intermediate lobe of the rat pituitary gland is negatively coupled to adenylate cyclase

1982 • 62 citations

Lisuride versus bromocriptine treatment in Parkinson disease

1982 • 61 citations

Antagonism of apomorphine-induced yawning by SCH 23390: Evidence against the autoreceptor hypothesis

1986 • 59 citations

Neuroleptic-induced acute dyskinesias in squirrel monkeys: Correlation with propensity to cause extrapyramidal side effects

1980 • 58 citations

Regulation of phosphorylation of proteins I, IIIa, and IIIb in rat neurohypophysis in vitro by electrical stimulation and by neuroactive agents.

1982 • 58 citations

Distinct target size of dopamine D-1 and D-2 receptors in rat striatum

1984 • 58 citations

Involvement of septal and striatal dopamine D-2 receptors in yawning behavior in rats

1986 • 57 citations

Quantitative autoradiographic localization of D-1 dopamine receptors in the rat brain: Use of the iodinated ligand [125I]SCH 23982

1986 • 56 citations

Thienopyridine derivatives identified as the first selective, full efficacy, dopamine D1 receptor agonists

1987 • 56 citations

Handbook of psychiatry and endocrinology

1983 • 55 citations

Specific binding of 3H-SCH 23390 to dopamine D1 receptors

1986 • 55 citations

[3H]SCH23390 has the characteristics of a dopamine receptor ligand in the rat central nervous system

1984 • 55 citations

Effect of the dopamine D-1 antagonist SCH 23390 on rotational behaviour induced by apomorphine and pergolide in 6-hydroxy-dopamine denervated rats

1985 • 55 citations

Synthesis, resolution, absolute stereochemistry, and enantioselectivity of 3',4'-dihydroxynomifensine

1984 • 54 citations

SCH 23390 and SK&F 83566 are antagonists at vascular dopamine and serotonin receptors

1985 • 54 citations

Dystonia in Untreated Parkinsonism

1986 • 54 citations

Characterization of the Dopamine-Responsive Adenylate Cyclase of Bovine Parathyroid Cells and Its Relationship to Parathyroid Hormone Secretion

1980 • 53 citations

PHARMACOLOGICAL EVIDENCE FOR THE SUBCLASSIFICATION OF CENTRAL DOPAMINE RECEPTORS IN THE RAT

1982 • 53 citations

Yawning is elicited by D2 dopamine agonists but is blocked by the D1 antagonist, SCH 23390

1987 • 53 citations

Pharmacologic evidence for direct dopaminergic regulation of striatal acetylcholine release

1986 • 53 citations

Involvement of the D-2 dopamine receptor in the neuroleptic-induced decrease in nigral substance P

1984 • 52 citations

Peripheral dopamine receptor subtypes — a closer look

1985 • 51 citations

Topography of dopamine behaviours mediated by D1 and D2 receptors revealed by intrastriatal injection of SKF 38393, lisuride and apomorphine in rats with a unilateral 6-hydroxydopamine-induced lesion

1987 • 50 citations

Kainate lesion dissociates striatal dopamine receptor radioligand binding sites

1981 • 50 citations

Stimulation of pre- and postsynaptic dopamine receptors by an ergoline and by a partial ergoline

1981 • 50 citations

Presynaptic regulation of tyrosine hydroxylase activity in rat striatal synaptosomes by dopamine analogs.

1980 • 49 citations

Postsynaptic dopamine agonistic effects of 3-PPP enantiomers revealed by bilateral 6-hydroxy-dopamine lesions and by chronic reserpine treatment in rats

1984 • 49 citations

An electrophysiological analysis of the actions of the 3-PPP enantiomers on the nigrostriatal dopamine system

1985 • 49 citations

Role of nigral dopamine in amphetamine-induced locomotor activity

1983 • 48 citations

SCH 23390 blocks D-1 and D-2 dopamine receptors in rat neostriatum in vitro

1984 • 48 citations

Effects of dopamine depletion on rotational behavior to dopamine agonists

1983 • 48 citations

The effects of SCH 23390, YM 09151-2, (+)- and (−)-3-PPP and some classical neuroleptics on D-1 and D-2 receptors in rat neostriatum in vitro

1984 • 48 citations

Sensorimotor impairment and elevated levels of dopamine metabolites in the neostriatum occur rapidly after intranigral injection of 6-hydroxydopamine or gamma-hydroxybutyrate in awake rats

1984 • 47 citations

SCH 23390, a selective dopamine D1 antagonist, activates dopamine neurons but fails to prevent their inhibition by apomorphine

1985 • 47 citations

Opposite responses in the striato-nigral substance P system to D1 and D2 receptor activation

1984 • 47 citations

Dopamine D-2 receptors inhibit D-1 stimulated cyclic AMP accumulation in striatum but not limbic forebrain

1987 • 47 citations

Autoradiographic localization of D1 dopamine receptors in the rat brain with [3H]SKF 38393

1985 • 47 citations

SCH 23390 dissociated from conventional neuroleptics in apomorphine climbing and primate acute dyskinesia models

1985 • 46 citations

Differential effects of selective and non-selective neuroleptics on intracellular and extracellular cyclic AMP accumulation in rat striatal slices

1985 • 46 citations

Specific Inhibition of Dopamine D‐1‐Mediated Cyclic AMP Formation by Dopamine D‐2, Muscarinic Cholinergic, and Opiate Receptor Stimulation in Rat Striatal Slices

1986 • 46 citations

SCH23390 effects on apomorphine-induced responses of nigral dopaminergic neurons.

1986 • 46 citations

Comparison of the CNS effects induced by TRH and bicuculline after microinjection into medial septum, substantia nigra and inferior colliculus: Absence of support for a GABA antagonist action for TRH

1984 • 46 citations

The putative dopamine autoreceptor agonist B-HT 920 decreases nigral dopamine cell firing rate and prolactin release in rat

1985 • 45 citations

Sedative, hypnotic, and antipsychotic effects of low doses of apomorphine in man.

1977 • 45 citations

Blockade of D-2 dopamine receptors strongly enhances the potency of enkephalins to inhibit dopamine-sensitive adenylate cyclase in rat neostriatum: involvement of delta- and mu-opioid receptors

1986 • 44 citations

Transdihydrolisuride, a partial dopamine receptor antagonist: Effects on monoamine metabolism

1984 • 44 citations

Differential blocking effects of several dopamine receptor antagonists for peripheral pre- and postsynaptic dopamine receptors in the anesthetized dog.

1982 • 44 citations

The enantiomers of SK&F 83566, a new selective D-1 dopamine antagonist, stereospecifically block stereotyped behaviour induced by apomorphine and by the selective D-2 agonist RU 24213

1985 • 44 citations

Evidence for the existence of vascular alpha 2-adrenergic receptors in humans.

1984 • 43 citations

Postsynaptic dopamine (DA) receptor stimulator properties of the putative DA autoreceptor-selective agonist B-HT 920 uncovered by co-treatment with the D-1 agonist SK&F 38393

1987 • 42 citations

Identification of the enantiomers of SK&F 83566 as specific and stereoselective antagonists at the striatal D-1 dopamine receptor: Comparisons with the D-2 enantioselectivity of Ro 22-1319

1984 • 42 citations

Inhibition of SKF 38393- and pergolide-induced circling in rats with unilateral 6-OHDA lesion is correlated to dopamine D-1 and D-2 receptor affinitiesin vitro

1986 • 42 citations

Neuroleptic-induced acute dyskinesias in rhesus monkeys

1981 • 41 citations

Dopamine D2 receptor mediation of the discriminative stimulus properties of LY 171555 (quinpirole)

1986 • 41 citations

Behavioral effects of chronic exposure to selective D-1 and D-2 dopamine receptor agonists

1988 • 40 citations

SCH23390 causes persistent antidopaminergic effects in vivo: Evidence for longterm occupation of receptors

1985 • 40 citations

Lisuride in the Treatment of Parkinsonism

1983 • 39 citations

Opposing roles for D-1 and D-2 dopamine receptors in regulating the excitability of growth hormone-producing cells in the snail Lymnaea stagnalis

1984 • 39 citations

Differential reversal by scopolamine and thip of the antistereotypic and cataleptic effects of neuroleptics

1981 • 39 citations

Molecular size of the canine and human brain D2 dopamine receptor as determined by radiation inactivation.

1983 • 38 citations

Differential effect of repeated treatment with l-DOPA on dopamine-D1 or -D2 receptors

1986 • 38 citations

Lergotrile mesylate: an in vivo dopamine agonist which blocks dopamine receptors in vitro.

1977 • 38 citations

Dopamine D1 receptor mediation of the discriminative stimulus properties of SKF 38393

1985 • 37 citations

The use of dopamine agonists in the treatment of schizophrenia.

1981 • 37 citations

Characterization of dopaminergic receptors in dispersed bovine parathyroid cells.

1980 • 37 citations

Effects of dopamine agonists, catecholamine depletors, and cholinergic and GABAergic drugs on acute dyskinesias in squirrel monkeys

1983 • 37 citations

Pergolide mesylate and idiopathic Parkinson disease

1982 • 36 citations

In vivo receptor binding, neurochemical and functional studies with the dopamine D-1 receptor antagonist SCH 23390

1988 • 36 citations

Nigral dopaminergic mechanisms in drug-induced circling

1983 • 36 citations

(+)- and (−)-3-PPP exhibit different intrinsic activity at striatal dopamine autoreceptors controlling dopamine synthesis

1984 • 35 citations

Parkinson's Disease. Biochemistry, Clinical Pathology, and Treatment

1983 • 35 citations

SCH 23390 may alter dopamine-mediated motor behaviour via striatal D-1 receptors

1985 • 35 citations

YM-09151-2: A potent antagonist for a peripheral D2-dopamine receptor

1982 • 35 citations

Electrophysiological studies on EMD 23 448, an indolyl-3-butylamine, in the rat: A putative selective dop amine autoreceptor agonist

1983 • 35 citations

Lisuride in Parkinson disease

1981 • 35 citations

Binding of a novel dopaminergic agonist radioligand [3H]-fenoldopam1 (SKF 82526) to D-1 receptors in rat striatum

1985 • 35 citations

[3H]SCH 23390 Binding to Human Putamen D‐1 Dopamine Receptors: Stereochemical and Structure‐Affinity Relationships Among l‐Phenyl‐1H‐3‐Benzazepine Derivatives as a Guide to D‐l Receptor Topography

1987 • 34 citations

Dopamine D1-receptor stimulation reduces neostriatal cholecystokinin release

1984 • 34 citations

The Dopamine D1 Receptor: Biochemical and Behavioral Aspects

1986 • 34 citations

Effects of selective dopamine D2-receptor agonists on the release of cholecystokinin-like immunoreactivity from rat neostriatum

1984 • 33 citations

Identification of the binding subunit of the D1-dopamine receptor by photoaffinity crosslinking.

1987 • 33 citations

Electrophysiological study of the effects of D1 and D2 dopamine antagonists on the interaction of converging inputs from the sensory-motor cortex and substantia nigra neurons in the rat

1986 • 33 citations

Potent lipophilic substituted benzamide drugs are not selective D-1 dopamine receptor antagonists in the rat

1983 • 32 citations

Evidence that Dopamine is a Neurotransmitter in the Neurointermediate Lobe of the Hypophysis

1983 • 32 citations

Differential down-regulation of D1-stimulated adenylate cyclase activity in rat forebrain after in vivo amphetamine treatments

1986 • 32 citations

[3H]SCH 23390 identifies D-1 binding sites in rat striatum and other brain areas

1986 • 32 citations

Studies in vitro with ICI 174, 864, [D-Pen2, D-Pen5]-enkephalin (DPDPE) and [D-Ala2, NMePhe4, Gly-ol]-enkephalin (DAGO)

1985 • 31 citations

Functional antagonism of D-1 and D-2 dopaminergic mechanisms affecting striatal acetylcholine release

1986 • 31 citations

The effect of apomorphine and pergolide on the potassium-evoked overflow of GABA in rat striatum studied by microdialysis

1986 • 30 citations

Selectivity of agonists and antagonists at D2dopamine receptors compared to D1 and S2receptors

1986 • 30 citations

The D1 dopamine agonist SKF 38393 functions as a discriminative stimulus in rats

1985 • 30 citations

SCH 23390 antagonizes apomorphine- and ergot-induced hypothermia

1986 • 30 citations

B-HT 920 and B-HT 958: Presynaptic effects on electrically evoked 3H-dopamine release from slices of rat nucleus accumbens

1987 • 29 citations

SCH 23390, a selective D1 dopamine receptor blocker, enhances the firing rate of nigral dopaminergic neurons but fails to activate striatal tyrosine hydroxylase

1985 • 29 citations

The use of L-DOPA in Parkinson's disease: a 20 year follow-up

1981 • 29 citations

A comparison of dopamine agonist action to inhibit locomotor activity and to induce stereotyped behaviour in the mouse

1984 • 29 citations

Evidence for a specific effect of BHT 920, an azepine derivative, on tyrosine hydroxylase in the dopaminergic system of the rat

1986 • 28 citations

D-l and D-2 dopaminergic receptors regulate protein phosphorylation in the rat neurohypophysis

1985 • 27 citations

Induction of turning by direct intrastriatal injection of dopaminomimetic drugs in mice: Pharmacological analysis of a simple screening model

1986 • 27 citations

Behavioural correlates to the dopamine D-1 and D-2 antagonists.

1984 • 27 citations

Parkinson’s Disease: Biochemistry, Clinical Pathology, and Treatment

1983 • 26 citations

D-1 dopamine receptor stimulaiton elevates plasma prolactin levels

1986 • 26 citations

Identification of Dopamine “D3′’ and “D4′’ Binding Sites, Labelled with [3H]2‐Amino‐6,7‐Dihydroxy‐ 1,2,3,4‐ Tetrahydronaphthalene, as High Agonist Affinity States of the D1 and D2 Dopamine Receptors, Respectively

1986 • 25 citations

Bromocriptine potentiates the behavioural effects of directly and indirectly acting dopamine receptor agonists in mice

1985 • 24 citations

Review on neuroleptic receptors: specificity and multiplicity of in vitro binding related to pharmacological activity

1981 • 24 citations

Hypothesis: Bromocriptine lacks intrinsic dopamine receptor stimulating properties

1985 • 24 citations

ANALYSIS OF HISTAMINE RECEPTORS IN THE CENTRAL THERMOREGULATORY MECHANISM OF Mastomys natalensis

1982 • 23 citations

“Selective” D-1 and D-2 receptor antagonists fail to differentially alter supersensitive locomotor behavior in the rat

1986 • 23 citations

Biochemical and pharmacological activities of zetidoline (DL 308-IT): a new antidopaminergic agent

1982 • 23 citations

Separation of dopamine D1 and D2 receptors

1985 • 23 citations

Characterization of Dopamine D-1 and D-2 Receptors

1986 • 23 citations

Lisuride combined with levodopa in advanced Parkinson disease

1981 • 22 citations

Inhibition of striatal tyrosine hydroxylase by low concentrations of apomorphine

1984 • 21 citations

New Directions in Tardive Dyskinesia Research

1984 • 21 citations

Central dopaminergic properties of HW-165 and its enantiomers; Trans-octahydrobenzo(f)quinoline congeners of 3-PPP

1986 • 21 citations

Bromocriptine and lisuride in Parkinson disease

1983 • 20 citations

The Bulimic Disorders

1986 • 20 citations

Activation of adenylate cyclase in rat striatum by an ergoline dopamine agonist, pergolide.

1980 • 20 citations

A homologous series of N-alkylated cis-(+)-(1 S, 2 R)-5-methoxy-1-methyl-2-aminotetralins: Central dopamine receptor antagonists showing profiles ranging from classical antagonism to selectivity for autoreceptors

1986 • 20 citations

Neuroleptic Classification: Implications for Tardive Dyskinesia

2015 • 19 citations

Behavioural effects mediated by unilateral nigral dopamine receptor stimulation in the rat

1984 • 18 citations

Regulation of agonist and antagonist binding to striatal D-1 dopamine receptors: Studies using the selective D-1 antagonist [3H]SK&F R-83566

1986 • 18 citations

Modulation by fenoldopam (SKF 82526) and bromocriptine of the electrically evoked release of vasopressin from the rat neurohypophysis

1986 • 17 citations

Behavioral Differences between Neonatal and Adult 6-Hydroxydopamine-Treated Rats to Dopamine Agonists: Relevance to Neurological Symptoms in Clinical Syndromes with Reduced Brain Dopamine

1984 • 17 citations

Stimulus Properties of Dopaminergic Drugs: Comparisons Involving Selective Agonists and Antagonists

1988 • 17 citations

Turning behaviour following nigral injections of dopamine agonists and glycine

1982 • 16 citations

Lisuride in the treatment of Parkinsonism

2009 • 16 citations

Treatment of Parkinsonʼs disease with dopamine agonists: A review

1979 • 15 citations

Effects of D-1 and D-2 Receptor Stimulation on Single Unit Activity in the Substantia Nigra and Globus Pallidus

1986 • 15 citations

Enhancing effect of dopamine blockers on evoked acetylcholine release in rat striatal slices: a classical D-2 antagonist response?

1986 • 15 citations

Clinical Pharmacology in Psychiatry: Neuroleptic and Antidepressant Research

1983 • 15 citations

Behavioural and Biochemical Studies With the Benzamide Sulpiride in Rats

1984 • 15 citations

Inhibition of K+-stimulated [3H]dopamine and [14C]acetylcholine release by the putative dopamine autoreceptor agonist, B-HT 920

1986 • 14 citations

Monkey Models of Tardive Dyskinesia1

2015 • 14 citations

Classification of neuroleptics: implications for tardive dyskinesia.

1985 • 13 citations

On the Supersensitivity of DA-Receptors After Single and Repeated Administration of Neuroleptics

1980 • 13 citations

Biochemical characteristics of D1 dopamine receptors: relationship to behavior and schizophrenia.

1986 • 13 citations

D-1/D-2 dopamine receptor interactions in the regulation of extrapyramidal motor function: studies in animal models and parkinsonian patients.

1986 • 13 citations

Dopamine Decreases the Amplitude of Excitatory Post-Synaptic Potentials in Rat Striatal Neurones

1984 • 12 citations

In Situ Molecular Size of Agonist Dopamine D-2 Binding Sites in Rat Striatum

1987 • 12 citations

Binding of [3H]SKF 38393 to Dopamine D‐l Receptors in Rat Striatum In Vitro; Estimation of Receptor Molecular Size by Radiation Inactivation

1987 • 12 citations

Evidence that diphenylhydantoin does not affect adenosine triphosphatases from brain

1976 • 12 citations

Differential electrophysiological effects of 3-PPP and its enantiomers on dopamine autoreceptors and postsynaptic receptors

1986 • 12 citations

Absence of dopamine sensitive adenylate cyclase in the A10 region, the origin of mesolimbic dopamine neurones

1979 • 11 citations

Zetidoline, a novel neuroleptic, activates nigral dopaminergic neurons in rats

1985 • 11 citations

Studies on the dopamine agonist properties of 8-amino-2-methyl-4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline, a derivative of nomifensine

1978 • 11 citations

DOPAMINERGIC ERGOT DERIVATIVES: SELECTIVE AGONISTS OF A NEW CLASS OF DOPAMINE RECEPTORS?

1979 • 11 citations

A Primate Model for Tardive Dyskinesia

1980 • 10 citations

Release of cholecystokinin-like immunoreactivity from slices of dorsal and ventral striatum of rat brain

1984 • 9 citations

TREATMENT OF PARKINSONʼS DISEASE WITH A DOPAMINE PARTIAL AGONIST

1984 • 9 citations

D-1 and D-2 receptor manipulation in Cebus monkeys: implication for extrapyramidal syndromes in humans.

1986 • 8 citations

Dopamine D2 receptors photolabelled by [3H]azido-methylspiperone

1986 • 8 citations

LY141865, a D2-dopamine agonist, increases acetylcholine concentration in rat corpus striatum

1983 • 7 citations

The use of pergolide, a potent dopamine agonist, in parkinson's disease

1982 • 6 citations

New Perspectives in the Treatment of Parkinsonʼs Disease

1986 • 5 citations

Independent Dopamine D-1 and D-2 Receptor Regulation of Dopamine Agonist-induced Hyperactivity in 6-OHDA Lesioned Rats; but not in Normal Rats

1986 • 2 citations

Deleted Work

1955 • 0 citations

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Review: D1 dopamine receptor—the search for a function: A critical evaluation of the… (1987) – Synapse | Metascience Observatory Explorer