Analysis of the influences of the E5 transforming protein on kinetic parameters of epidermal growth factor binding and metabolism

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii

2007 • 11,720 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

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1980 • 3,978 citations

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1971 • 1,547 citations

125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts.

1976 • 1,293 citations

RECEPTORS FOR EPIDERMAL GROWTH FACTOR AND OTHER POLYPEPTIDE MITOGENS

1987 • 1,274 citations

Epidermal Growth Factor and a New Derivative

1972 • 1,225 citations

Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor

1987 • 624 citations

Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activation

1987 • 508 citations

Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing

1987 • 479 citations

Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body

1990 • 452 citations

Movement of internalized ligand–receptor complexes along a continuous endosomal reticulum

1990 • 428 citations

Ligand-Induced Transformation by a Noninternalizing Epidermal Growth Factor Receptor

1990 • 415 citations

Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation

1989 • 356 citations

The epidermal growth factor receptor as a multifunctional allosteric protein

1988 • 286 citations

Anomalous binding of epidermal growth factor to A431 cells is due to the effect of high receptor densities and a saturable endocytic system.

1988 • 236 citations

A steady state model for analyzing the cellular binding, internalization and degradation of polypeptide ligands

1981 • 236 citations

Activation of the platelet-derived growth factor receptor by the bovine papillomavirus E5 transforming protein.

1991 • 224 citations

Receptor-mediated endocytosis of epidermal growth factor by rat hepatocytes: receptor pathway.

1986 • 217 citations

Mechanism of epidermal growth factor receptor autophosphorylation and high-affinity binding.

1987 • 209 citations

Quantitative analysis of the endocytic system involved in hormone-induced receptor internalization.

1990 • 207 citations

Signal transduction by epidermal growth factor occurs through the subclass of high affinity receptors.

1989 • 200 citations

Bovine papillomavirus E5 oncoprotein binds to the 16K component of vacuolar H+-ATPases

1991 • 182 citations

The bovine papillomavirus E5 transforming protein can stimulate the transforming activity of EGF and CSF-1 receptors

1989 • 176 citations

High-affinity epidermal growth factor binding is specifically reduced by a monoclonal antibody, and appears necessary for early responses.

1990 • 150 citations

Internalization of functional epidermal growth factor:receptor/kinase complexes in A-431 cells.

1985 • 128 citations

Multiple autophosphorylation site mutations of the epidermal growth factor receptor. Analysis of kinase activity and endocytosis

1991 • 114 citations

Recycling of epidermal growth factor-receptor complexes in A431 cells: identification of dual pathways.

1991 • 102 citations

The effect of receptor density on the forward rate constant for binding of ligands to cell surface receptors

1987 • 96 citations

Mutational removal of the Thr669 and Ser671 phosphorylation sites alters substrate specificity and ligand-induced internalization of the epidermal growth factor receptor.

1990 • 92 citations

Rate constants for binding, dissociation, and internalization of EGF: effect of receptor occupancy and ligand concentration

1990 • 91 citations

How Receptors Bring Proteins and Particles into Cells

1984 • 85 citations

Separate endocytic pathways of kinase-defective and -active EGF receptor mutants expressed in same cells.

1990 • 84 citations

Perinuclear location and recycling of epidermal growth factor receptor kinase: immunofluorescent visualization using antibodies directed to kinase and extracellular domains.

1986 • 78 citations

Rapid constitutive internalization and externalization of epidermal growth factor receptors in isolated rat hepatocytes. Monensin inhibits receptor externalization and reduces the capacity for continued endocytosis of epidermal growth factor.

1988 • 78 citations

Dimerization of internalized epidermal growth factor receptors.

1991 • 75 citations

[9] Binding assays for epidermal growth factor

1985 • 72 citations

Receptor-ligand interaction: a new method for determining binding parameters without a priori assumptions on non-specific binding

1989 • 55 citations

Reconstitution of the high affinity epidermal growth factor receptor on cell-free membranes after transmodulation by platelet-derived growth factor.

1991 • 51 citations

Recycling of epidermal growth factor-receptor complexes in A431 cells

1989 • 48 citations

Epidermal growth factor receptor binding is not a simple one-step process

1989 • 38 citations

Methods for Characterization of Receptors Based on Receptor-Mediated Responses in Tissue or Intact Cell Preparations

1986 • 7 citations