Tbx3 Is a Downstream Target of the Wnt/β-Catenin Pathway and a Critical Mediator of β-Catenin Survival Functions in Liver Cancer

Exploration, normalization, and summaries of high density oligonucleotide array probe level data

2003 • 10,537 citations

Caught up in a Wnt storm: Wnt signaling in cancer

2003 • 1,473 citations

Molecular pathogenesis of human hepatocellular carcinoma

2002 • 1,424 citations

Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas

1998 • 1,085 citations

Expression of the T-box family genes,Tbx1-Tbx5, during early mouse development

1996 • 654 citations

Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis

2001 • 567 citations

Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome

1997 • 536 citations

T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification

1999 • 510 citations

Apc Tumor Suppressor Gene Is the “Zonation-Keeper” of Mouse Liver

2006 • 490 citations

Application of comparative functional genomics to identify best-fit mouse models to study human cancer

2004 • 461 citations

New targets of β-catenin signaling in the liver are involved in the glutamine metabolism

2002 • 386 citations

Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19ARF) and is amplified in a subset of human breast cancers

2000 • 367 citations

Genetics of hepatocellular carcinoma

2000 • 332 citations

Small interfering RNAs directed against beta-catenin inhibit the in vitro and in vivo growth of colon cancer cells.

2003 • 294 citations

FGF-20 and DKK1 are transcriptional targets of β-catenin and FGF-20 is implicated in cancer and development

2004 • 292 citations

Mammary gland, limb and yolk sac defects in mice lackingTbx3,the gene mutated in human ulnar mammary syndrome

2003 • 281 citations

Exogenous Expression of β-Catenin Regulates Contact Inhibition, Anchorage-Independent Growth, Anoikis, and Radiation-Induced Cell Cycle Arrest

1999 • 278 citations

Isl1Cre reveals a common Bmp pathway in heart and limb development

2006 • 265 citations

Liver-specific loss of β-catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice

2006 • 263 citations

Cisplatin, Doxorubicin, and Delayed Surgery for Childhood Hepatoblastoma: A Successful Approach—Results of the First Prospective Study of the International Society of Pediatric Oncology

2000 • 262 citations

Functional consequences of frizzled-7 receptor overexpression in human hepatocellular carcinoma

2004 • 243 citations

β-catenin antisense studies in embryonic liver cultures: Role in proliferation, apoptosis, and lineage specification

2003 • 216 citations

p19ARF directly and differentially controls the functions of c-Myc independently of p53

2004 • 216 citations

Wnt signaling promotes oncogenic transformation by inhibiting c-Myc–induced apoptosis

2002 • 210 citations

Epidermal Growth Factor Receptor: A Novel Target of the Wnt/β-Catenin Pathway in Liver

2005 • 209 citations

Control of the Gene optomotor-blind in Drosophila Wing Development by decapentaplegic and wingless

1996 • 206 citations

Predictive Value of the Pretreatment Extent of Disease System in Hepatoblastoma: Results From the International Society of Pediatric Oncology Liver Tumor Study Group SIOPEL-1 Study

2005 • 203 citations

β-Catenin is temporally regulated during normal liver development☆

2004 • 184 citations

Activation of β-catenin in epithelial and mesenchymal hepatoblastomas

2000 • 169 citations

Hepatomegaly in transgenic mice expressing an oncogenic form of beta-catenin.

2001 • 164 citations

TBX-3, the Gene Mutated in Ulnar-Mammary Syndrome, Is a Negative Regulator of p19 and Inhibits Senescence

2002 • 154 citations

Oncogenic role of the frizzled-7/β-catenin pathway in hepatocellular carcinoma

2005 • 151 citations

Tbx Genes Specify Posterior Digit Identity through Shh and BMP Signaling

2004 • 140 citations

TBX3 and Its Isoform TBX3+2a Are Functionally Distinctive in Inhibition of Senescence and Are Overexpressed in a Subset of Breast Cancer Cell Lines

2004 • 133 citations

Morphogenesis of chicken liver: identification of localized growth zones and the role of β-catenin/Wnt in size regulation

2003 • 124 citations

Transcription repression by Xenopus ET and its human ortholog TBX3, a gene involved in ulnar-mammary syndrome

1999 • 121 citations

Interactions between FGF and Wnt signals and Tbx3 gene expression in mammary gland initiation in mouse embryos

2004 • 107 citations

Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation during mouse lung organogenesis

2004 • 103 citations

Tbx3 impinges on the p53 pathway to suppress apoptosis, facilitate cell transformation and block myogenic differentiation

2002 • 100 citations

A -catenin-dependent pathway regulates expression of cytochrome P450 isoforms in mouse liver tumors

2004 • 96 citations

Activation of beta-catenin during hepatocarcinogenesis in transgenic mouse models: relationship to phenotype and tumor grade.

2001 • 94 citations

Overexpression of regenerating islet-derived 1 alpha and 3 alpha genes in human primary liver tumors with β-catenin mutations

2005 • 89 citations

Behind the Official Optimism, Flawed Projections

1996 • 89 citations

Increased expression of cSHMT, Tbx3 and utrophin in plasma of ovarian and breast cancer patients

2005 • 76 citations

LvTbx2/3: a T-box family transcription factor involved in formation of the oral/aboral axis of the sea urchin embryo

2003 • 70 citations

Regulation of Tbx3 Expression by Anteroposterior Signalling in Vertebrate Limb Development

2002 • 65 citations

Liver-specific expression and high oncogenic efficiency of a c-myc transgene activated by woodchuck hepatitis virus insertion.

1994 • 51 citations

Hepatocellular carcinoma in WHV/N-myc2 transgenic mice: oncogenic mutations of β-catenin and synergistic effect of p53 null alleles

2000 • 48 citations

PML interacts with Myc, and Myc target gene expression is altered in PML-null fibroblasts

2005 • 42 citations

Conserved expression control and shared activity between cognate T‐box genes Tbx2 and Tbx3 in connection with Sonic hedgehog signaling during Xenopus eye development

2002 • 40 citations

Prognostic impact of molecular genetic alterations in hepatoblastoma

2002 • 33 citations