FGF-20 and DKK1 are transcriptional targets of β-catenin and FGF-20 is implicated in cancer and development

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A System for Stable Expression of Short Interfering RNAs in Mammalian Cells

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β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

1999 • 3,566 citations

LMO2 -Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1

2003 • 3,480 citations

Wnt signaling and cancer

2000 • 3,215 citations

The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway

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The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells

2002 • 1,984 citations

Wnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway

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Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

1998 • 1,587 citations

Secreted antagonists of the Wnt signalling pathway

2003 • 1,543 citations

Linking Colorectal Cancer to Wnt Signaling

2000 • 1,507 citations

The Role of the Wnt-Signaling Antagonist DKK1 in the Development of Osteolytic Lesions in Multiple Myeloma

2003 • 1,491 citations

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2000 • 1,303 citations

Wnt Signaling in Oncogenesis and Embryogenesis--a Look Outside the Nucleus

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Association of the APC Gene Product with β-Catenin

1993 • 1,215 citations

Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein.

1995 • 1,025 citations

Expression of a xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction

1991 • 980 citations

Analysis of Messy Data, Volume I: Designed Experiments

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FORMATION AND FUNCTION OF SPEMANN'S ORGANIZER

1997 • 836 citations

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

2001 • 696 citations

Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center

1991 • 651 citations

Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene.

1995 • 551 citations

New aspects of Wnt signaling pathways in higher vertebrates

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A β-catenin/XTcf-3 complex binds to thesiamois promoter to regulate dorsal axis specification in Xenopus

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Mapping chromosomal proteins in vivo by formaldehyde-crosslinked-chromatin immunoprecipitation

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The DF-1 Chicken Fibroblast Cell Line: Transformation Induced by Diverse Oncogenes and Cell Death Resulting from Infection by Avian Leukosis Viruses

1998 • 403 citations

A transcriptional response to Wnt protein in human embryonic carcinoma cells

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Xwnt-8, a Xenopus Wnt-1/int-1-related gene responsive to mesoderminducing growth factors, may play a role in ventral mesodermal patterning during embryogenesis

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Apc modulates embryonic stem-cell differentiation by controlling the dosage of β-catenin signaling

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Expression of a dominant-negative Wnt blocks induction of MyoD in Xenopus embryos.

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Regulation of Wnt Signaling by Sox Proteins

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Neoplastic Transformation of RK3E by Mutant β-Catenin Requires Deregulation of Tcf/Lef Transcription but Not Activation of c-myc Expression

1999 • 313 citations

FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1^−/− mice

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Mesoderm induction in Xenopus is a zygotic event regulated by maternal VegT via TGFβ growth factors

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Diverse mechanisms of beta-catenin deregulation in ovarian endometrioid adenocarcinomas.

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The homeobox gene Siamois is a target of the Wnt dorsalisation pathway and triggers organiser activity in the absence of mesoderm

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ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias.

1993 • 199 citations

The Wnt antagonist Dickkopf-1 is regulated by Bmp signaling and c-Jun and modulates programmed cell death

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Neural crest-directed gene transfer demonstrates Wnt1 role in melanocyte expansion and differentiation during mouse development

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The EV-O-Derived Cell Line DF-1 Supports the Efficient Replication of Avian Leukosis-Sarcoma Viruses and Vectors

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Nr-CAM is a target gene of the β-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis

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Wnt/β-Catenin Signaling Induces the Expression and Activity of βTrCP Ubiquitin Ligase Receptor

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Development of a flexible and specific gene delivery system for production of murine tumor models

1999 • 170 citations

Involvement of the FGF18 gene in colorectal carcinogenesis, as a novel downstream target of the beta-catenin/T-cell factor complex.

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Curbing the nuclear activities of β‐catenin

2000 • 163 citations

naked cuticle targets dishevelled to antagonize Wnt signal transduction

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ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with β-catenin defects and promotes neoplastic transformation

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Siamois is required for formation of Spemann’s organizer

1997 • 144 citations

Novel candidate targets of beta-catenin/T-cell factor signaling identified by gene expression profiling of ovarian endometrioid adenocarcinomas.

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TCF Is the Nuclear Effector of the β-Catenin Signal That Patterns the Sea Urchin Animal–Vegetal Axis

2000 • 137 citations

Wnt Target Genes Identified by DNA Microarrays in Immature CD34+ Thymocytes Regulate Proliferation and Cell Adhesion

2004 • 117 citations

Intestinal dysplasia and adenoma in transgenic mice after overexpression of an activated beta-catenin.

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Wnt11 Signaling Promotes Proliferation, Transformation, and Migration of IEC6 Intestinal Epithelial Cells

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Tyrosine kinase signalling in breast cancer: Fibroblast growth factors and their receptors

2000 • 90 citations

Region-specific activation of the Xenopus Brachyury promoter involves active repression in ectoderm and endoderm: a study using transgenic frog embryos

2000 • 90 citations

Silencing of Wnt Signaling and Activation of Multiple Metabolic Pathways in Response to Thyroid Hormone-Stimulated Cell Proliferation

2001 • 89 citations

Zygotic Wnt Activity Is Required for Brachyury Expression in the Early Xenopus laevis Embryo

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A role for maternal -catenin in early mesoderm induction in Xenopus

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Difference in XTcf-3 dependency accounts for change in response to β-catenin-mediated Wnt signalling inXenopusblastula

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Identification of a novel human fibroblast growth factor and characterization of its role in oncogenesis.

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Axis Induction by Wnt Signaling: Target Promoter Responsiveness Regulates Competence

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A Mouse Model for Glioma: Biology, Pathology, and Therapeutic Opportunities

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Control over Wnt target gene expression

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Characterization of a Novel Member of the FGF Family, XFGF-20, in Xenopus laevis

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Cyclin D1 is not an essential target of beta-catenin signaling during intestinal tumorigenesis, but it may act as a modifier of disease severity in multiple intestinal neoplasia (Min) mice.

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Chromosomal translocations and leukaemia: a role for LMO2 in T cell acute leukaemia, in transcription and in erythropoiesis.

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Ets oncogene family.

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Characterization of a human colonic adenocarcinoma cell line, LS123

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