Th1 to Th2 Cytokine Shifts in Nonobese Diabetic Mice: Sometimes an Outcome, Rather Than the Cause, of Diabetes Resistance Elicited by Immunostimulation

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

REGULATION OF IMMUNE RESPONSES BY TGF-β

1998 • 1,908 citations

Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes

1993 • 1,753 citations

Generation and Analysis of Interleukin-4 Deficient Mice

1991 • 1,266 citations

Insulin-Dependent Diabetes Mellitus

1996 • 1,171 citations

The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model.

1995 • 768 citations

The Nonobese Diabetic Mouse as a Model of Autoimmune Diabetes: Immune Dysregulation Gets the NOD

1997 • 685 citations

B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice.

1996 • 581 citations

Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice.

1993 • 510 citations

Unequal Death in T Helper Cell (Th)1 and Th2 Effectors: Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis

1997 • 460 citations

Adoptive Transfer of Diabetes Into Immunodeficient NOD-scid/scid Mice: Relative Contributions of CD4+ and CD8+ T-Cells From Diabetic Versus Prediabetic NOD.NON-Thy-1a Donors

1993 • 431 citations

Recombinant Human IL-10 Prevents the Onset of Diabetes in the Nonobese Diabetic Mouse

1994 • 429 citations

Immunoregulatory and Cytokine Imbalances in the Pathogenesis of IDDM: Therapeutic Intervention by Immunostimulation?

1994 • 363 citations

Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice.

1996 • 311 citations

Production of interleukin 10 by islet cells accelerates immune-mediated destruction of beta cells in nonobese diabetic mice.

1994 • 300 citations

TECK: A Novel CC Chemokine Specifically Expressed by Thymic Dendritic Cells and Potentially Involved in T Cell Development

1997 • 292 citations

Genetic Absence of γ-Interferon Delays but Does Not Prevent Diabetes in NOD Mice

1996 • 244 citations

IL-4 prevents insulitis and insulin-dependent diabetes mellitus in nonobese diabetic mice by potentiation of regulatory T helper-2 cell function.

1997 • 224 citations

T Helper 2 (Th2) T Cells Induce Acute Pancreatitis and Diabetes in Immune-compromised Nonobese Diabetic (NOD) Mice

1997 • 223 citations

The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders.

1996 • 217 citations

Defective activation of T suppressor cell function in nonobese diabetic mice. Potential relation to cytokine deficiencies.

1988 • 199 citations

Differential ability of T cell subsets to undergo activation-induced cell death

1997 • 188 citations

TGF-β1 Alters APC Preference, Polarizing Islet Antigen Responses toward a Th2 Phenotype

1998 • 180 citations

Complete Freund's adjuvant-induced T cells prevent the development and adoptive transfer of diabetes in nonobese diabetic mice.

1993 • 176 citations

Induction of Glutamic Acid Decarboxylase 65-Specific Th2 Cells and Suppression of Autoimmune Diabetes at Late Stages of Disease Is Epitope Dependent

1999 • 173 citations

Hematopoietic stem-cell defects underlying abnormal macrophage development and maturation in NOD/Lt mice: defective regulation of cytokine receptors and protein kinase C.

1993 • 162 citations

IFN-gamma gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice.

1995 • 160 citations

Altered Cytokine Activity in Adjuvant Inhibition of Autoimmune Diabetes

1993 • 151 citations

TGF-beta1 somatic gene therapy prevents autoimmune disease in nonobese diabetic mice.

1998 • 137 citations

Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice. Relative contributions of CD4+ and CD8+ T-cells from diabetic versus prediabetic NOD.NON-Thy-1a donors

1993 • 125 citations

Interferon-gamma receptor signaling is dispensable in the development of autoimmune type 1 diabetes in NOD mice.

2000 • 124 citations

Activation-driven T cell death. II. Quantitative differences alone distinguish stimuli triggering nontransformed T cell proliferation or death.

1992 • 120 citations

Intrathymic Islet Cell Transplantation Reduces β-Cell Autoimmunity and Prevents Diabetes in NOD/Lt Mice

1992 • 118 citations

Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Therapeutic intervention by immunostimulation?

1994 • 112 citations

TGF-β1 Somatic Gene Therapy Prevents Autoimmune Disease in Nonobese Diabetic Mice

1998 • 112 citations

Protection of Nonobese Diabetic Mice from Diabetes by Gene(s) Closely Linked to IFN-γ Receptor Loci

2000 • 99 citations

Breaking self-tolerance in nonobese diabetic mice.

1996 • 88 citations

Interleukin-4 Deficiency Does Not Exacerbate Disease in NOD Mice

1998 • 87 citations

Genetic absence of gamma-interferon delays but does not prevent diabetes in NOD mice

1996 • 86 citations

Splenic Macrophages From the NOD Mouse Are Defective in the Ability to Present Antigen

1998 • 84 citations

Abrogation of autoimmune diabetes in nonobese diabetic mice and protection against effector lymphocytes by transgenic paracrine TGF-beta1.

1998 • 77 citations

Inhibition of Diabetes by an Insulin-Reactive CD4 T-Cell Clone in the Nonobese Diabetic Mouse

1997 • 66 citations

CD4+ beta islet cell-reactive T cell clones that suppress autoimmune diabetes in nonobese diabetic mice.

1995 • 57 citations

Development of diabetogenic T cells from NOD/Lt marrow is blocked when an allo-H-2 haplotype is expressed on cells of hemopoietic origin, but not on thymic epithelium.

1991 • 57 citations

Limits to the differential avidity model of T cell selection in the thymus.

1997 • 48 citations

Distinction between immunogenicity and tolerogenicity among HBcAg T cell determinants. Influence of peptide-MHC interaction.

1989 • 44 citations

Induction of Diabetes in Nonobese Diabetic Mice by Th2 T Cell Clones from a TCR Transgenic Mouse

2000 • 42 citations

Intrathymic islet cell transplantation reduces beta-cell autoimmunity and prevents diabetes in NOD/Lt mice

1992 • 41 citations

Inhibition of diabetes by an insulin-reactive CD4 T-cell clone in the nonobese diabetic mouse

1997 • 24 citations

Evidence of Positive Cross-Regulation on Th1 by Th2 and Antigen-Presenting Cells: Effects on Th1 Induced by IL-4 and IL-12

1999 • 15 citations