In Vivo Expression of a TCR Antagonist: T Cells Escape Central Tolerance But Are Antagonized in the Periphery

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system

1974 • 2,058 citations

Binding of immunogenic peptides to Ia histocompatibility molecules

1985 • 1,209 citations

Sequence analysis of peptides bound to MHC class II molecules

1991 • 1,071 citations

Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens.

1980 • 850 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

T-cell-receptor affinity and thymocyte positive selection

1996 • 620 citations

Partial T cell signaling: Altered phospho-? and lack of zap70 recruitment in APL-induced T cell anergy

1994 • 608 citations

Structure of the p53 Tumor Suppressor Bound to the Ankyrin and SH3 Domains of 53BP2

1996 • 569 citations

Separation of IL-4 Production from Th Cell Proliferation by an Altered T Cell Receptor Ligand

1991 • 565 citations

ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists

1995 • 510 citations

Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor

1992 • 501 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

Development and Selection of T Cells: Facts and Puzzles

1995 • 450 citations

The Repertoire of T Cells Shaped by a Single MHC/Peptide Ligand

1996 • 417 citations

Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands

1993 • 414 citations

Structures of an MHC Class II Molecule with Covalently Bound Single Peptides

1996 • 369 citations

Essential flexibility in the T-cell recognition of antigen

1996 • 330 citations

T cell receptor antagonists and partial agonists

1995 • 303 citations

Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells.

1994 • 299 citations

Differential requirements for antigen processing by macrophages for lysozyme-specific T cell hybridomas.

1984 • 272 citations

Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells.

1993 • 266 citations

The fine specificity of antigen and la determinant recognition by T cell hybridoma clones specific for pigeon cytochrome c

1982 • 244 citations

A differential-avidity model for T-cell selection

1994 • 239 citations

Specificity and flexibility in thymic selection

1994 • 221 citations

Specific T cell recognition of minimally homologous peptides: Evidence for multiple endogenous Ligands

1995 • 209 citations

Structural basis for T cell recognition of altered peptide ligands: a single T cell receptor can productively recognize a large continuum of related ligands.

1996 • 208 citations

Use of global amino acid replacements to define the requirements for MHC binding and T cell recognition of moth cytochrome c (93-103).

1994 • 185 citations

A Range of CD4 T Cell Tolerance: Partial Inactivation to Organ-Specific Antigen Allows Nondestructive Thyroiditis or Insulitis

1997 • 178 citations

Th2 cell clonal anergy as a consequence of partial activation.

1994 • 175 citations

In vivo and in vitro clonal deletion of double-positive thymocytes.

1992 • 172 citations

Characterization and Quantitation of Peptide–MHC Complexes Produced from Hen Egg Lysozyme Using a Monoclonal Antibody

1997 • 169 citations

Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8+ T cells

1995 • 161 citations

Peptides in positive and negative selection: A delicate balance

1994 • 153 citations

Mature T cell reactivity altered by peptide agonist that induces positive selection.

1996 • 148 citations

In Thymic Selection, Peptide Diversity Gives and Takes Away

1997 • 136 citations

Complete dissection of the Hb(64-76) determinant using T helper 1, T helper 2 clones, and T cell hybridomas.

1992 • 131 citations

Monoclonal antibody detection of a major self peptide. MHC class II complex.

1992 • 127 citations

Differential T cell signaling induced by antagonist peptide-MHC complexes and the associated phenotypic responses.

1997 • 89 citations

Class II-restricted presentation of an endogenously derived immunodominant T-cell determinant of hen egg lysozyme.

1991 • 89 citations

Negative selection of CD4+ CD8+ thymocytes by T-cell receptor peptide antagonists.

1994 • 88 citations

A vector driving the expression of foreign cDNAs in the MHC class II-positive cells of transgenic mice

1993 • 87 citations

A peptide antigen antagonist prevents the differentiation of T cell receptor transgenic thymocytes.

1994 • 86 citations

Anergy as a mechanism of peripheral T cell tolerance.

1996 • 62 citations

Endogenous altered peptide ligands can affect peripheral T cell responses.

1996 • 59 citations

Modulation of T cell development by an endogenous altered peptide ligand.

1995 • 45 citations

Inhibition of thymocyte negative selection by T cell receptor antagonist peptides

1996 • 36 citations

The agonist-antagonist balance in positive selection

1997 • 35 citations

The T cell receptor as a diverse signal transduction machine.

1996 • 22 citations

Crystallization and preliminary X-ray diffraction studies of two new antigen-antibody (lysozyme-Fab) complexes

1988 • 19 citations