Crystal Structure and Mutational Analysis of the Human CDK2 Kinase Complex with Cell Cycle–Regulatory Protein CksHs1

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1976 • 225,752 citations

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1976 • 200,127 citations

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

AMoRe: an automated package for molecular replacement

1994 • 4,990 citations

Principles of CDK regulation

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Solvent-Accessible Surfaces of Proteins and Nucleic Acids

1983 • 2,685 citations

Cyclins and cancer II: Cyclin D and CDK inhibitors come of age

1994 • 2,122 citations

Crystallographic R Factor Refinement by Molecular Dynamics

1987 • 1,982 citations

Improved Fourier coefficients for maps using phases from partial structures with errors

1986 • 1,897 citations

The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.

1993 • 1,459 citations

Vectors for selective expression of cloned DNAs by T7 RNA polymerase

1987 • 1,449 citations

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

1995 • 1,407 citations

Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis

1989 • 1,237 citations

Crystal structure of cyclin-dependent kinase 2

1993 • 946 citations

A family of human cdc2-related protein kinases.

1992 • 928 citations

RIBBONS 2.0

1991 • 814 citations

Myt1: A Membrane-Associated Inhibitory Kinase That Phosphorylates Cdc2 on Both Threonine-14 and Tyrosine-15

1995 • 658 citations

A simple and efficient procedure for transformation of yeasts.

1992 • 637 citations

A novel cyclin associates with M015/CDK7 to form the CDK-activating kinase

1994 • 636 citations

Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution

1994 • 591 citations

Regulation of p34cdc2 protein kinase during mitosis

1989 • 544 citations

Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15.

1993 • 475 citations

The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae

1991 • 463 citations

The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues.

1993 • 391 citations

p13suc1 acts in the fission yeast cell division cycle as a component of the p34cdc2 protein kinase.

1987 • 387 citations

Braking the cycle

1993 • 378 citations

The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2.

1993 • 377 citations

Three protein kinase structures define a common motif

1994 • 364 citations

Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas.

1993 • 347 citations

Fission yeast p13 blocks mitotic activation and tyrosine dephosphorylation of the Xenopus cdc2 protein kinase

1989 • 327 citations

CAK, the p34cdc2 activating kinase, contains a protein identical or closely related to p40MO15.

1993 • 326 citations

The Role of p34 Kinases in the G1 to S-Phase Transition

1992 • 313 citations

The decision to enter mitosis

1994 • 270 citations

The fission yeast cell cycle control gene cdc2: isolation of a sequence suc1 that suppresses cdc2 mutant function

1986 • 222 citations

The Saccharomyces cerevisiae CKS1 gene, a homolog of the Schizosaccharomyces pombe suc1+ gene, encodes a subunit of the Cdc28 protein kinase complex.

1989 • 206 citations

Insights into autoregulation from the crystal structure of twitchin kinase

1994 • 192 citations

Crystal structure of casein kinase-1, a phosphate-directed protein kinase.

1995 • 187 citations

Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe.

1990 • 181 citations

Dephosphorylation of Cdk2 Thr ¹⁶⁰ by the Cyclin-Dependent Kinase-Interacting Phosphatase KAP in the Absence of Cyclin

1995 • 170 citations

suc1 is an essential gene involved in both the cell cycle and growth in fission yeast

1986 • 165 citations

Sucl+ encodes a predicted 13-kilodalton protein that is essential for cell viability and is directly involved in the division cycle of Schizosaccharomyces pombe.

1987 • 158 citations

Cyclin-dependent kinases: a new cell cycle motif?

1991 • 148 citations

Domain movements in protein kinases

1994 • 129 citations

Human CksHs2 Atomic Structure: a Role for Its Hexameric Assembly in Cell Cycle Control

1993 • 123 citations

The Cdk-associated protein Cks1 functions both in G1 and G2 in Saccharomyces cerevisiae.

1993 • 99 citations

The function(s) of CAK, the p34cdc2-activating kinase

1994 • 76 citations

The crystal structure of p13suc1, a p34cdc2-interacting cell cycle control protein.

1995 • 74 citations

Purification of a 15-kDa cdk4- and cdk5-binding protein.

1994 • 73 citations

Crystal Structure of the Human Cell Cycle Protein CksHs1: Single Domain Fold with Similarity to Kinase N-lobe Domain

1995 • 72 citations

p13suc1 suppresses the catalytic function of p34cdc2 kinase for intermediate filament proteins, in vitro.

1992 • 70 citations

Crystal structure of the cell cycle-regulatory protein suc1 reveals a beta-hinge conformational switch.

1995 • 66 citations

Mutations at sites involved in Suc1 binding inactivate Cdc2.

1991 • 63 citations

A three-dimensional model of the Cdc2 protein kinase: localization of cyclin- and Suc1-binding regions and phosphorylation sites.

1993 • 62 citations

Protein kinases

1994 • 60 citations

Direct activation of cdc2 with phosphatase: identification of p13^sucl‐sensitive and insensitive steps

1990 • 35 citations

The cell cycle and suc1: from structure to function?

1995 • 32 citations

Crystallization and preliminary crystallographic study of human CksHs1: A cell cycle regulatory protein

1995 • 9 citations