Possible involvement of the α1 isoform of 5′AMP-activated protein kinase in oxidative stress-stimulated glucose transport in skeletal muscle

The L-Arginine-Nitric Oxide Pathway

1993 • 6,737 citations

Role of AMP-activated protein kinase in mechanism of metformin action

2001 • 5,086 citations

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

1973 • 2,608 citations

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

2002 • 2,024 citations

Free radicals and tissue damage produced by exercise

1982 • 1,754 citations

Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria

1980 • 1,609 citations

Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase

1996 • 1,222 citations

Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria

1985 • 1,201 citations

The Anti-diabetic Drugs Rosiglitazone and Metformin Stimulate AMP-activated Protein Kinase through Distinct Signaling Pathways

2002 • 1,027 citations

Nitric oxide in skeletal muscle

1994 • 972 citations

A Role for AMP-Activated Protein Kinase in Contraction- and Hypoxia-Regulated Glucose Transport in Skeletal Muscle

2001 • 935 citations

Evidence for 5′AMP-Activated Protein Kinase Mediation of the Effect of Muscle Contraction on Glucose Transport

1998 • 749 citations

Role of ubiquinone in the mitochondrial generation of hydrogen peroxide

1976 • 656 citations

Mammalian AMP-activated Protein Kinase Subfamily

1996 • 631 citations

The regulation of AMP-activated protein kinase by phosphorylation

2000 • 582 citations

5′‐AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP‐activated protein kinase. Studies using bacterially expressed human protein phosphatase‐2Cα and native bovine protein phosphatase‐2A_c

1995 • 582 citations

Respiratory chain linked H₂O₂ production in pigeon heart mitochondria

1971 • 544 citations

Metabolic stress and altered glucose transport: activation of AMP-activated protein kinase as a unifying coupling mechanism.

2000 • 463 citations

Aging and acute exercise enhance free radical generation in rat skeletal muscle

1999 • 454 citations

The effect of hyperoxia on superoxide production by lung submitochondrial particles

1982 • 442 citations

AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the α2 isoform

1998 • 431 citations

Isoform‐specific and exercise intensity‐dependent activation of 5′‐AMP‐activated protein kinase in human skeletal muscle

2000 • 431 citations

Exercise regulation of glucose transport in skeletal muscle

1997 • 422 citations

Purification and characterization of the AMP‐activated protein kinase

1989 • 413 citations

Nitric oxide release is present from incubated skeletal muscle preparations

1994 • 410 citations

Contraction-induced Changes in Acetyl-CoA Carboxylase and 5′-AMP-activated Kinase in Skeletal Muscle

1997 • 404 citations

AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation

2000 • 350 citations

Exercise Induces Isoform-Specific Increase in 5′AMP-Activated Protein Kinase Activity in Human Skeletal Muscle

2000 • 350 citations

Roles of 5′-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis

2003 • 337 citations

Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle

1998 • 330 citations

Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport

1998 • 329 citations

Phosphorylation-activity relationships of AMPK and acetyl-CoA carboxylase in muscle

2002 • 309 citations

Reactive oxygen in skeletal muscle. II. Extracellular release of free radicals

1992 • 308 citations

The Regulation of AMP-Activated Protein Kinase by H2O2

2001 • 300 citations

NADH- and NADPH-dependent formation of superoxide anions by bovine heart submitochondrial particles and NADH–ubiquinone reductase preparation

1979 • 293 citations

Electron spin resonance studies of intact mammalian skeletal muscle

1985 • 289 citations

Location and function of three sites phosphorylated on rat acetyl‐CoA carboxylase by the AMP‐activated protein kinase

1990 • 262 citations

The α1 and α2 isoforms of the AMP‐activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro

1996 • 260 citations

Nitric Oxide Increases Glucose Uptake Through a Mechanism That Is Distinct From the Insulin and Contraction Pathways in Rat Skeletal Muscle

2001 • 258 citations

AMP-activated protein kinase activity and glucose uptake in rat skeletal muscle

2001 • 226 citations

Exercise-induced oxidative stress: glutathione supplementation and deficiency

1994 • 226 citations

MDA content increases in fast- and slow-twitch skeletal muscle with intensity of exercise in a rat

1988 • 212 citations

Molecular Characterization of a Superoxide-Generating NAD(P)H Oxidase in the Ventilatory Muscles

2002 • 211 citations

The mitochondrial site of superoxide formation

1986 • 208 citations

Modulation by Peroxynitrite of Akt- and AMP-activated Kinase-dependent Ser1179 Phosphorylation of Endothelial Nitric Oxide Synthase

2002 • 190 citations

Production of hydroxyl radicals in contracting skeletal muscle of cats

1996 • 172 citations

Activation of 5′-AMP-activated Kinase Is Mediated through c-Src and Phosphoinositide 3-Kinase Activity during Hypoxia-Reoxygenation of Bovine Aortic Endothelial Cells

2003 • 166 citations

Exercise Increases Nuclear AMPK α2 in Human Skeletal Muscle

2003 • 152 citations

Progressive increase in human skeletal muscle AMPKα2 activity and ACC phosphorylation during exercise

2002 • 147 citations

Generation of Reactive Oxygen and Nitrogen Species in Contracting Skeletal Muscle

2002 • 140 citations

Isoform-specific Purification and Substrate Specificity of the 5′-AMP-activated Protein Kinase

1996 • 131 citations

Cellular expression of xanthine oxidoreductase protein in normal human tissues.

1999 • 120 citations

Exercise increases susceptibility of muscle glucose transport to activation by various stimuli

1990 • 115 citations

Lengthening contraction-induced inflammation is linked to secondary damage but devoid of neutrophil invasion

2002 • 95 citations

Analysis of Glutathione and Glutathione Disulfide in Whole Cells and Mitochondria by Postcolumn Derivatization High-Performance Liquid Chromatography with ortho-Phthalaldehyde

1999 • 78 citations

14 Adenine Nucleotide Metabolism In Contracting Skeletal Muscle

1991 • 74 citations

Changes in voltage activation of contraction in frog skeletal muscle fibres as a result of sarcoplasmic reticulum Ca²⁺‐ATPase activity

1999 • 65 citations

Effects of free radicals on cytosolic creatine kinase activities and protection by antioxidant enzymes and sulfhydryl compounds.

2000 • 59 citations

Exogenous reactive oxygen and nitric oxide alter intracellular oxidant status of skeletal muscle fibres

1999 • 59 citations

Xanthine oxidase-derived H2O2 contributes to reperfusion injury of ischemic skeletal muscle

1990 • 48 citations

Long-term regulation of AMP-activated protein kinase and acetyl-CoA carboxylase in skeletal muscle

2003 • 32 citations