Site and mechanism of leptin action in a rodent form of congenital lipodystrophy

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Nonalcoholic Fatty Liver Disease

2002 • 5,091 citations

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

Cellular mechanisms of insulin resistance

2000 • 2,692 citations

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

2002 • 2,024 citations

Triglyceride accumulation protects against fatty acid-induced lipotoxicity

2003 • 1,800 citations

Leptin-Replacement Therapy for Lipodystrophy

2002 • 1,201 citations

A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance

1998 • 1,173 citations

Loss of stearoyl–CoA desaturase-1 function protects mice against adiposity

2002 • 1,066 citations

Physiological response to long-term peripheral and central leptin infusion in lean and obese mice

1997 • 1,043 citations

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy

1999 • 1,040 citations

Role for Stearoyl-CoA Desaturase-1 in Leptin-Mediated Weight Loss

2002 • 825 citations

Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

1998 • 797 citations

Life without white fat: a transgenic mouse

1998 • 782 citations

Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol

1999 • 737 citations

Acute stimulation of glucose metabolism in mice by leptin treatment

1997 • 717 citations

Obesity in the new millennium

2000 • 707 citations

A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis.

1977 • 705 citations

Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice

2000 • 669 citations

Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

2002 • 588 citations

High Rates of Fatty Acid Oxidation during Reperfusion of Ischemic Hearts Are Associated with a Decrease in Malonyl-CoA Levels Due to an Increase in 5’-AMP-activated Protein Kinase Inhibition of Acetyl-CoA Carboxylase

1995 • 582 citations

Selective deletion of leptin receptor in neurons leads to obesity

2001 • 533 citations

Leptin-specific patterns of gene expression in white adipose tissue

2000 • 519 citations

Liver-specific disruption of PPARγ in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes

2003 • 509 citations

Differentiation-induced gene expression in 3T3-L1 preadipocytes. Characterization of a differentially expressed gene encoding stearoyl-CoA desaturase.

1988 • 359 citations

Mechanisms and regulation of biosynthesis of saturated fatty acids.

1976 • 340 citations

Transgenic Overexpression of Leptin Rescues Insulin Resistance and Diabetes in a Mouse Model of Lipoatrophic Diabetes

2001 • 239 citations

Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype

2003 • 237 citations

Increased insulin sensitivity in mice lacking p85β subunit of phosphoinositide 3-kinase

2001 • 229 citations

Insulin activation of acetyl-CoA carboxylase accompanied by inhibition of the 5'-AMP-activated protein kinase.

1992 • 221 citations

Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin.

1999 • 211 citations

Leptin restores euglycemia and normalizes glucose turnover in insulin-deficient diabetes in the rat.

1999 • 200 citations

Hepatic malonyl-CoA levels of fed, fasted and diabetic rats as measured using a simple radioisotopic assay.

1978 • 193 citations

PPARα is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue

2002 • 179 citations

Leptin Activates Cardiac Fatty Acid Oxidation Independent of Changes in the AMP-activated Protein Kinase-Acetyl-CoA Carboxylase-Malonyl-CoA Axis

2002 • 179 citations

Decreased IRS-2 and Increased SREBP-1c Lead to Mixed Insulin Resistance and Sensitivity in Livers of Lipodystrophic and ob/ob Mice

2000 • 166 citations

Transplantation of Adipose Tissue Lacking Leptin Is Unable to Reverse the Metabolic Abnormalities Associated With Lipoatrophy

2002 • 146 citations

Chronic intracerebroventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity

1993 • 145 citations

Lipoatrophic diabetes in Irs1^−/−/Irs3^−/− double knockout mice

2002 • 129 citations

Inhibition of rat liver acetyl coenzyme A carboxylase by long chain acyl coenzyme A and fatty acid. Modulation by fatty acid-binding protein.

1977 • 111 citations

Oleoyl-CoA Is the Major de NovoProduct of Stearoyl-CoA Desaturase 1 Gene Isoform and Substrate for the Biosynthesis of the Harderian Gland 1-Alkyl-2,3-diacylglycerol

2001 • 110 citations

Acute intravenous leptin infusion increases glucose turnover but not skeletal muscle glucose uptake in ob/ob mice.

1999 • 93 citations

Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells

1997 • 63 citations

CNS melanocortin and leptin effects on stearoyl-CoA desaturase-1 and resistin expression

2003 • 46 citations

Mechanism of glucoregulatory responses to stress and their deficiency in diabetes.

1991 • 41 citations