Leptin as an adjunct of insulin therapy in insulin-deficient diabetes

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

1993 • 23,535 citations

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Central nervous system control of food intake

2000 • 6,305 citations

Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans

1996 • 6,254 citations

Leptin and the regulation of body weight in mammals

1998 • 5,366 citations

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

1995 • 3,730 citations

Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action

1995 • 1,630 citations

Leptin-Replacement Therapy for Lipodystrophy

2002 • 1,201 citations

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy

1999 • 1,040 citations

Ghrelin, an Endogenous Growth Hormone Secretagogue, Is a Novel Orexigenic Peptide That Antagonizes Leptin Action Through the Activation of Hypothalamic Neuropeptide Y/Y1 Receptor Pathway

2001 • 862 citations

Acute stimulation of glucose metabolism in mice by leptin treatment

1997 • 717 citations

Response of melanocortin–4 receptor–deficient mice to anorectic and orexigenic peptides

1999 • 549 citations

Unraveling the central nervous system pathways underlying responses to leptin

1998 • 520 citations

Pathophysiological role of leptin in obesity-related hypertension

2000 • 479 citations

Hypoglycemia in the Diabetes Control and Complications Trial. The Diabetes Control and Complications Trial Research Group

1997 • 430 citations

Identification of Type I Diabetic Patients at Increased Risk for Hypoglycemia during Intensive Therapy

1983 • 394 citations

Effect of Intracerebroventricular Insulin Infusion on Diabetic Hyperphagia and Hypothalamic Neuropeptide Gene Expression

1995 • 361 citations

Weight Gain Associated With Intensive Therapy in the Diabetes Control and Complications Trial

1988 • 317 citations

Adverse Events and Their Association With Treatment Regimens in the Diabetes Control and Complications Trial

1995 • 297 citations

Transgenic Overexpression of Leptin Rescues Insulin Resistance and Diabetes in a Mouse Model of Lipoatrophic Diabetes

2001 • 239 citations

Intracerebroventricular Leptin Regulates Hepatic but Not Peripheral Glucose Fluxes

1998 • 229 citations

Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin.

1999 • 211 citations

Marked and rapid decreases of circulating leptin in streptozotocin diabetic rats: reversal by insulin

1998 • 203 citations

Leptin restores euglycemia and normalizes glucose turnover in insulin-deficient diabetes in the rat.

1999 • 200 citations

Involvement of agouti-related protein, an endogenous antagonist of hypothalamic melanocortin receptor, in leptin action.

1999 • 176 citations

Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans

1996 • 169 citations

Accelerated puberty and late-onset hypothalamic hypogonadism in female transgenic skinny mice overexpressing leptin

2000 • 151 citations

Effects of streptozotocin-induced diabetes and insulin treatment on the hypothalamic melanocortin system and muscle uncoupling protein 3 expression in rats.

2000 • 130 citations

Central leptin increases insulin sensitivity in streptozotocin-induced diabetic rats

2002 • 121 citations

Low plasma leptin levels contribute to diabetic hyperphagia in rats.

1999 • 119 citations

Chronic central leptin infusion restores hyperglycemia independent of food intake and insulin level in streptozotocin‐induced diabetic rats

2002 • 106 citations

Glucose metabolism and insulin sensitivity in transgenic mice overexpressing leptin with lethal yellow agouti mutation: usefulness of leptin for the treatment of obesity-associated diabetes.

1999 • 92 citations

Metformin improved insulin resistance in type I, insulin-dependent, diabetic patients

1985 • 82 citations

STZ-induced diabetes decreases and insulin normalizes POMC mRNA in arcuate nucleus and pituitary in rats

1999 • 77 citations

Serum leptin levels in children and adolescents with insulin-dependent diabetes mellitus in relation to metabolic control and body mass index

1998 • 74 citations

Effect of a high-fat diet on food intake and hypothalamic neuropeptide gene expression in streptozotocin diabetes.

1998 • 62 citations

Changes in Plasma Leptin during the Treatment of Diabetic Ketoacidosis

1999 • 28 citations

Insulin requirement for the antihyperglycaemic effect of metformin

1994 • 12 citations

Changes in Plasma Leptin during the Treatment of Diabetic Ketoacidosis

1999 • 12 citations

Deleted Work

1955 • 0 citations