The p38/Reactivating Kinase Mitogen-activated Protein Kinase Cascade Mediates the Activation of the Transcription Factor Insulin Upstream Factor 1 and Insulin Gene Transcription by High Glucose in Pancreatic β-Cells

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

1995 • 2,080 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

IPF1, a homeodomain-containing transactivator of the insulin gene.

1993 • 882 citations

FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2.

1996 • 633 citations

MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase.

1992 • 486 citations

Pancreatic beta cell line MIN6 exhibits characteristics of glucose metabolism and glucose-stimulated insulin secretion similar to those of normal islets

1993 • 430 citations

IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene.

1994 • 427 citations

Automated Islet Isolation From Human Pancreas

1989 • 369 citations

Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38)

1997 • 363 citations

Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells.

1993 • 332 citations

Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes.

1994 • 207 citations

The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2

1993 • 196 citations

Transcriptional control of metabolic regulation genes by carbohydrates

1994 • 191 citations

Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoters.

1993 • 177 citations

Regulation of insulin gene expression by glucose and calcium in transfected primary islet cultures.

1990 • 174 citations

Metabolic Regulation of Gene Transcription in Mammals

1995 • 160 citations

Positive and negative regulation of the human insulin gene by multiple trans-acting factors.

1990 • 156 citations

The Insulin Gene Contains Multiple Transcriptional Elements That Respond to Glucose

1994 • 145 citations

XIHbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factor.

1994 • 141 citations

A comparison of the substrate specificity of MAPKAP kinase‐2 and MAPKAP kinase‐3 and their activation by cytokines and cellular stress

1996 • 137 citations

Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokine-stimulated monocytes and epithelial cells.

1996 • 134 citations

Glucose modulates the binding activity of the β-cell transcription factor IUF1 in a phosphorylation-dependent manner

1994 • 134 citations

Cellular Stresses and Cytokines Activate Multiple Mitogen‐Activated‐Protein Kinase Kinase Homologues in PC12 and KB Cells

1996 • 123 citations

Glucose-Induced Transcription of the Insulin Gene Is Mediated by Factors Required for β-Cell-Type-Specific Expression

1994 • 118 citations

The activation of distinct mitogen-activated protein kinase cascades is required for the stimulation of 2-deoxyglucose uptake by interleukin-1 and insulin-like growth factor-1 in KB cells

1995 • 91 citations

A tissue-specific nuclear factor binds to multiple sites in the human insulin-gene enhancer

1989 • 85 citations

Diabetes : clinical science in practice

1995 • 83 citations

Function of the Human Insulin Promoter in Primary Cultured Islet Cells

1996 • 82 citations

Control of insulin gene expression by glucose

1992 • 82 citations

The helix-loop-helix transcription factor USF (upstream stimulating factor) binds to a regulatory sequence of the human insulin gene enhancer

1993 • 69 citations

Human pancreatic islet isolation and transplantation

1994 • 50 citations

Human insulin gene enhancer‐binding proteins in pancreatic α and β cell lines

1993 • 20 citations

The insulin enhancer binding site 2 (IEB2; FAR) box of the insulin gene regulatory region binds at least three factors that can be distinguished by their DNA binding characteristics

1995 • 7 citations