Position independent expression and developmental regulation is directed by the β myosin heavy chain gene's 5′ upstream region in transgenic mice

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction

1990 • 1,583 citations

The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.

1982 • 1,371 citations

GERM-LINE TRANSFORMATION OF MICE

1986 • 1,165 citations

Chromatin as an essential part of the transcriptional mechanim

1992 • 853 citations

Enhanced Myocardial Function in Transgenic Mice Overexpressing the β ₂ -Adrenergic Receptor

1994 • 745 citations

All Members of the MHC Multigene Family Respond to Thyroid Hormone in a Highly Tissue-Specific Manner

1986 • 632 citations

Expression of the cardiac ventricular alpha- and beta-myosin heavy chain genes is developmentally and hormonally regulated.

1984 • 609 citations

A nuclear DNA attachment element mediates elevated and position-independent gene activity

1989 • 597 citations

Developmental regulation of myosin gene expression in mouse cardiac muscle.

1990 • 408 citations

Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy.

1994 • 369 citations

Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice

1990 • 364 citations

DNA looping between sites for transcriptional activation: self-association of DNA-bound Sp1.

1991 • 348 citations

Isolation and characterization of the mouse cardiac myosin heavy chain genes

1991 • 331 citations

Cardiac alpha- and beta-myosin heavy chain genes are organized in tandem.

1984 • 320 citations

Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription

1991 • 311 citations

Human gamma- to beta-globin gene switching in transgenic mice.

1990 • 291 citations

Tissue specific and position independent expression of the complete gene domain for chicken lysozyme in transgenic mice.

1990 • 289 citations

A yeast artificial chromosome covering the tyrosinase gene confers copy number-dependent expression in transgenic mice

1993 • 275 citations

In vivo footprinting of rat TAT gene: Dynamic interplay between the glucocorticoid receptor and a liver-specific factor

1991 • 270 citations

DNA looping and Sp1 multimer links: a mechanism for transcriptional synergism and enhancement.

1991 • 254 citations

Transgenes as probes for active chromosomal domains in mouse development

1988 • 251 citations

Cardiac myosin heavy chain mRNA expression and myocardial function in the mouse heart.

1991 • 228 citations

Regulation of myosin heavy chain genes in the heart.

1993 • 203 citations

Position independence and proper developmental control of gamma-globin gene expression require both a 5' locus control region and a downstream sequence element.

1994 • 194 citations

Mouse embryonic stem cells express the cardiac myosin heavy chain genes during development in vitro.

1990 • 175 citations

A MyoD1-independent muscle-specific enhancer controls the expression of the beta-myosin heavy chain gene in skeletal and cardiac muscle cells.

1991 • 175 citations

Regulation of myosin isoenzyme composition in fetal and neonatal rat ventricle by endogenous thyroid hormones.

1984 • 170 citations

Expression of a foreign gene in a line of transgenic mice is modulated by a chromosomal position effect.

1990 • 160 citations

Thyroid hormone regulates expression of a transfected human alpha-myosin heavy-chain fusion gene in fetal rat heart cells.

1990 • 147 citations

In vivo analysis of the murine beta-myosin heavy chain gene promoter.

1993 • 120 citations

Functional analysis of the human adenosine deaminase gene thymic regulatory region and its ability to generate position-independent transgene expression.

1992 • 108 citations

Regulation of alpha-fetoprotein gene expression by antagonism between AP-1 and the glucocorticoid receptor at their overlapping binding site

1991 • 103 citations

Developmental regulation of human gamma-globin genes in transgenic mice.

1993 • 100 citations

Interaction of thyroid hormone receptors with strong and weak cis-acting elements in the human alpha-myosin heavy chain gene promoter.

1990 • 98 citations

Patterns of expression of position-dependent integrated transgenes in mouse embryo.

1990 • 96 citations

Transgenic analysis of the thyroid-responsive elements in the alpha-cardiac myosin heavy chain gene promoter.

1993 • 93 citations

Regulation of the β-globin locus

1993 • 88 citations

Characterization of a strong positive cis-acting element of the human beta-myosin heavy chain gene in fetal rat heart cells.

1992 • 87 citations

In vivo regulation of the mouse beta myosin heavy chain gene.

1994 • 65 citations

Analysis of the human alpha-globin gene cluster in transgenic mice.

1993 • 65 citations

Far upstream regions of class II MHC Ea are necessary for position-independent, copy-dependent expression of Ea transgene

1993 • 56 citations

Expression of a Foreign Gene in a Line of Transgenic Mice Is Modulated by a Chromosomal Position Effect

1990 • 54 citations

Identification of cis Sequences Controlling Efficient PositionIndependent Tissue-Specific Expression of Human Major Histocompatibility Complex Class I Genes in Transgenic Mice

1991 • 53 citations

Transcriptional Insulation of the Human Keratin 18 Gene in Transgenic Mice

1993 • 52 citations

Identification of transgenic mice carrying the CAT gene with PCR amplification.

1989 • 43 citations

Cis-acting elements responsible for muscle-specific expression of the myosin heavy chain β gene

1992 • 42 citations

Functional Analysis of the Human Adenosine Deaminase Gene Thymic Regulatory Region and Its Ability To Generate Position-Independent Transgene Expression

1992 • 38 citations

Segregation of cardiac and skeletal muscle-specific regulatory elements of the beta-myosin heavy chain gene.

1995 • 36 citations

Differential effect of thyroxine on atrial and ventricular isomyosins in rats

1986 • 33 citations

Developmental Regulation of Human γ-Globin Genes in Transgenic Mice

1993 • 28 citations

Position Independence and Proper Developmental Control of γ-Globin Gene Expression Require both a 5′ Locus Control Region and a Downstream Sequence Element

1994 • 27 citations

Chromatin structure and gene expression

1992 • 25 citations

In Vivo Definition of a Cardiac Specific Promoter and Its Potential Utility in Remodeling the Heart

1995 • 24 citations

Chromatin structure of hormono-dependent promoters

1991 • 12 citations