Lipopolysaccharide (LPS)-induced Macrophage Activation and Signal Transduction in the Absence of Src-Family Kinases Hck, Fgr, and Lyn

Biologic basis for interleukin-1 in disease

1996 • 4,324 citations

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

Receptor-Dependent Mechanisms of Cell Stimulation by Bacterial Endotoxin

1995 • 1,436 citations

Interleukin-6 in Biology and Medicine

1993 • 1,398 citations

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

1993 • 1,129 citations

ENDOTOXINS AND DISEASE MECHANISMS

1987 • 1,119 citations

TUMOR NECROSIS FACTOR: A Pleiotropic Cytokine and Therapuetic Target

1994 • 1,047 citations

Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FeγRIIB

1996 • 770 citations

Resistance to Endotoxin Shock and Reduced Dissemination of Gram-Negative Bacteria in CD14-Deficient Mice

1996 • 760 citations

Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease

1995 • 710 citations

Recruitment and Activation of PTP1C in Negative Regulation of Antigen Receptor Signaling by FcγRIIB1

1995 • 535 citations

Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice

1995 • 475 citations

Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages.

1996 • 475 citations

Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages.

1992 • 402 citations

Resistance to fever induction and impaired acute-phase response in interleukin-1β-deficient mice

1995 • 365 citations

Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions.

1996 • 364 citations

Prevention of Lipopolysaccharide-Induced Lethal Toxicity by Tyrosine Kinase Inhibitors

1994 • 339 citations

Lipopolysaccharide induces activation of CD14-associated protein tyrosine kinase p53/56lyn.

1993 • 307 citations

Endotoxin induces rapid protein tyrosine phosphorylation in 70Z/3 cells expressing CD14.

1993 • 302 citations

Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories.

1996 • 286 citations

Lipopolysaccharide (LPS) partial structures inhibit responses to LPS in a human macrophage cell line without inhibiting LPS uptake by a CD14-mediated pathway.

1992 • 273 citations

Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity.

1994 • 232 citations

Involvement of protein kinase C and protein tyrosine kinase in lipopolysaccharide-induced TNF-alpha and IL-1 beta production by human monocytes.

1994 • 224 citations

Transgenic mice expressing human CD14 are hypersensitive to lipopolysaccharide.

1993 • 213 citations

Glycosyl-phosphatidylinositol-anchored or integral membrane forms of CD14 mediate identical cellular responses to endotoxin.

1993 • 183 citations

Lipopolysaccharide-induced protein tyrosine phosphorylation in human macrophages is mediated by CD14.

1993 • 177 citations

Development, differentiation, and phenotypic heterogeneity of murine tissue macrophages

1996 • 162 citations

Lipopolysaccharide‐induced cytokine production in human monocytes: Role of tyrosine phosphorylation in transmembrane signal transduction

1994 • 158 citations

CD14 and other recognition molecules for lipopolysaccharide: A review

1995 • 153 citations

Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice.

1996 • 152 citations

Bacterial lipopolysaccharide has structural similarity to ceramide and stimulates ceramide-activated protein kinase in myeloid cells

1994 • 142 citations

Bacterial lipopolysaccharide induces the association and coordinate activation of p53/56lyn and phosphatidylinositol 3-kinase in human monocytes.

1996 • 130 citations

Hck tyrosine kinase activity modulates tumor necrosis factor production by murine macrophages.

1993 • 121 citations

Lipopolysaccharide response is linked to the GTP binding protein, Gi2, in the promonocytic cell line U937

1989 • 119 citations

Studies into the Effect of the Tyrosine Kinase Inhibitor Herbimycin A on NF-κB Activation in T Lymphocytes EVIDENCE FOR COVALENT MODIFICATION OF THE p50 SUBUNIT

1995 • 118 citations

Activation of Raf-1 and mitogen-activated protein kinase in murine macrophages partially mimics lipopolysaccharide-induced signaling events.

1995 • 115 citations

Lipopolysaccharide- and interferon-gamma-induced expression of hck and lyn tyrosine kinases in murine bone marrow-derived macrophages.

1992 • 115 citations

B-cell antigen receptor motifs have redundant signalling capabilities and bind the tyrosine kinases PTK72, Lyn and Fyn

1993 • 112 citations

Integrin αvβ5-dependent Serine Phosphorylation of Paxillin in Cultured Human Macrophages Adherent to Vitronectin

1996 • 110 citations

Augmented expression of a myeloid-specific protein tyrosine kinase gene (hck) after macrophage activation.

1988 • 102 citations

Identification of a new serine kinase that activates NF kappa B by direct phosphorylation.

1993 • 96 citations

Lipopolysaccharide stimulates the tyrosine phosphorylation of mitogen-activated protein kinases p44, p42, and p41 in vascular endothelial cells in a soluble CD14-dependent manner. Role of protein tyrosine phosphorylation in lipopolysaccharide-induced stimulation of endothelial cells.

1995 • 92 citations

Establishment of Lipopolysaccharide-dependent Nuclear Factor κB Activation in a Cell-free System

1995 • 81 citations

Lipopolysaccharide Receptors and Signal Transduction Pathways in Mononuclear Phagocytes

1992 • 72 citations

Defective ceramide response in C3H/HeJ (Lpsd) macrophages.

1995 • 59 citations

A novel Yes-related kinase, Yrk, is expressed at elevated levels in neural and hematopoietic tissues.

1993 • 54 citations

LPS and Taxol Activate Lyn Kinase Autophosphorylation in Lpsn, but Not in Lpsd, Macrophages

1995 • 46 citations

Molecular mechanisms for activated macrophage recognition of tumor cells.

1991 • 19 citations

Effects of Interleukin 4 Upon Human Tumoricidal Cells Obtained From Patients Bearing Solid Tumors

1991 • 10 citations