ENDOTOXINS AND DISEASE MECHANISMS

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

Tumor Necrosis Factor (TNF)

1985 • 1,932 citations

Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.

1986 • 1,501 citations

Control of Cachectin (Tumor Necrosis Factor) Synthesis: Mechanisms of Endotoxin Resistance

1986 • 1,305 citations

Identity of tumour necrosis factor and the macrophage-secreted factor cachectin

1985 • 1,125 citations

Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells.

1985 • 833 citations

The effects of bacterial endotoxins on host mediation systems. A review.

1978 • 648 citations

Interleukin 1 stimulates fibroblasts to produce granulocyte-macrophage colony-stimulating activity and prostaglandin E2.

1986 • 458 citations

PREVENTION OF GRAM-NEGATIVE SHOCK AND DEATH IN SURGICAL PATIENTS BY ANTIBODY TO ENDOTOXIN CORE GLYCOLIPID

1985 • 381 citations

Multiple biological activities of human recombinant interleukin 1.

1986 • 372 citations

Local and Systemic Effects of Intradermal Recombinant Interferon-γ in Patients with Lepromatous Leprosy

1986 • 328 citations

Protection against gram-negative bacteremia and endotoxemia with human monoclonal IgM antibodies.

1985 • 316 citations

Platelet activating factor (PAF) involvement in endotoxin-induced hypotension in rats. studies with paf-receptor antagonist kadsurenone

1985 • 298 citations

Macrophage-mediated tumor cell killing: regulation of expression of cytolytic activity by prostaglandin E.

1981 • 238 citations

Activation of the Properdin Pathway of Complement in Patients with Gram-Negative Bacteremia

1975 • 235 citations

Interleukin 1 stimulates platelet activating factor production in cultured human endothelial cells

1986 • 232 citations

Immunoreactive beta-endorphin in a subpopulation of mouse spleen macrophages.

1984 • 172 citations

Production of peptide leukotrienes in endotoxin shock

1985 • 118 citations

Immunocytochemical detection of interleukin 1 within stimulated human monocytes.

1986 • 105 citations

Platelet-activating factor-induced ischemic bowel necrosis. An investigation of secondary mediators in its pathogenesis.

1986 • 95 citations

Activation of human serum complement by bacterial lipopolysaccharides: Structural requirements for antibody independent activation of the classical and alternative pathways

1987 • 88 citations

Recombinant interferons increase macrophage Fc receptor capacity.

1984 • 85 citations

Early-phase endotoxin tolerance: induction by a detoxified lipid A derivative, monophosphoryl lipid A

1986 • 69 citations

Molecular requirement for interleukin 1 induction by lipopolysaccharide‐stimulated human monocytes: Involvement of the heptosyl‐2‐keto 3‐deoxyoctulosonate region

1986 • 65 citations

Evidence that platelet activating factor may mediate some acute inflammatory responses. Studies with the platelet-activating factor antagonist, CV3988.

1986 • 41 citations

Interleukin-1 secretion by human alveolar macrophages stimulated with endotoxin is augmented by recombinant immune (gamma) interferon.

1986 • 34 citations

Microthrombosis during endotoxemia: Potential role of hepatic versus alveolar macrophages

1984 • 25 citations

Characterization of a two-signal-dependent, Ia+ mononuclear phagocyte progenitor subpopulation that is sensitive to inhibition by ferritin.

1986 • 22 citations

Sequential serum complement (C3) and immunoglobulin levels in shock/trauma patients developing acute fulminant systemic sepsis.

1985 • 20 citations

Monocyte-derived recruiting activity: kinetics of production and effects of endotoxin

1985 • 19 citations

FDA guideline for validation of the LAL test as an end-product endotoxin test for human and biological drugs.

1982 • 7 citations