Physiological and pathophysiological roles of adiponectin and adiponectin receptors in the integrated regulation of metabolic and cardiovascular diseases

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

2001 • 4,874 citations

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

2002 • 4,335 citations

A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes

1995 • 3,159 citations

Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

2003 • 3,114 citations

Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome

2006 • 2,715 citations

The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

2001 • 2,534 citations

MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity

2006 • 2,496 citations

AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity

1996 • 2,229 citations

cDNA Cloning and Expression of a Novel Adipose Specific Collagen-like Factor, apM1 (AdiposeMost Abundant Gene Transcript 1)

1996 • 2,082 citations

Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice

2001 • 1,903 citations

Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions

2007 • 1,305 citations

Adipose Tissue

2006 • 1,009 citations

Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl–CoA carboxylase inhibition and AMP-activated protein kinase activation

2002 • 969 citations

Impaired Multimerization of Human Adiponectin Mutants Associated with Diabetes

2003 • 962 citations

Globular Adiponectin Protected ob/ob Mice from Diabetes and ApoE-deficient Mice from Atherosclerosis

2003 • 922 citations

Isolation and Characterization of GBP28, a Novel Gelatin-Binding Protein Purified from Human Plasma

1996 • 919 citations

Overexpression of Monocyte Chemoattractant Protein-1 in Adipose Tissues Causes Macrophage Recruitment and Insulin Resistance

2006 • 875 citations

Adiponectin Stimulates AMP-Activated Protein Kinase in the Hypothalamus and Increases Food Intake

2007 • 794 citations

Measurement of the High–Molecular Weight Form of Adiponectin in Plasma Is Useful for the Prediction of Insulin Resistance and Metabolic Syndrome

2006 • 565 citations

Insulin/Foxo1 Pathway Regulates Expression Levels of Adiponectin Receptors and Adiponectin Sensitivity

2004 • 543 citations

The metabolic syndrome and adipocytokines

2006 • 541 citations

Peroxisome Proliferator–Activated Receptor (PPAR)α Activation Increases Adiponectin Receptors and Reduces Obesity-Related Inflammation in Adipose Tissue

2005 • 398 citations

Pioglitazone Ameliorates Insulin Resistance and Diabetes by Both Adiponectin-dependent and -independent Pathways

2006 • 317 citations

Osmotin Is a Homolog of Mammalian Adiponectin and Controls Apoptosis in Yeast through a Homolog of Mammalian Adiponectin Receptor

2005 • 208 citations

A novel ELISA system for selective measurement of human adiponectin multimers by using proteases

2006 • 154 citations

Selective purification and characterization of adiponectin multimer species from human plasma

2007 • 149 citations

The role of the adipocyte hormone adiponectin in cardiovascular disease

2005 • 111 citations