Human NK cells: their ligands, receptors and functions

Biology of Natural Killer Cells

1989 • 2,970 citations

In search of the ‘missing self’: MHC molecules and NK cell recognition

1990 • 2,600 citations

The Immunoglobulin Superfamily—Domains for Cell Surface Recognition

1988 • 2,237 citations

„Natural”︁ killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype

1975 • 1,743 citations

Severe Herpesvirus Infections in an Adolescent without Natural Killer Cells

1989 • 1,251 citations

Antigen Recognition by Class I-Restricted T Lymphocytes

1989 • 1,207 citations

The Human Cytomegalovirus US11 Gene Product Dislocates MHC Class I Heavy Chains from the Endoplasmic Reticulum to the Cytosol

1996 • 1,083 citations

Herpes simplex virus turns off the TAP to evade host immunity

1995 • 736 citations

Cloning of Immunoglobulin-Superfamily Members Associated with HLA-C and HLA-B Recognition by Human Natural Killer Cells

1995 • 735 citations

Recruitment of Tyrosine Phosphatase HCP by the Killer Cell Inhibitory Receptor

1996 • 625 citations

A viral inhibitor of peptide transporters for antigen presentation

1995 • 599 citations

Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains

1995 • 575 citations

P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities.

1993 • 537 citations

The Bw4 public epitope of HLA-B molecules confers reactivity with natural killer cell clones that express NKB1, a putative HLA receptor.

1995 • 507 citations

Protection from Natural Killer Cell-Mediated Lysis by HLA-G Expression on Target Cells

1996 • 489 citations

Human cytomegalovirus encodes a glycoprotein homologous to MHC class-I antigens

1988 • 470 citations

HLA-C is the inhibitory ligand that determines dominant resistance to lysis by NK1- and NK2-specific natural killer cells.

1993 • 455 citations

Existence of both inhibitory (p58) and activatory (p50) receptors for HLA-C molecules in human natural killer cells.

1995 • 446 citations

Many of the Immunoglobulin Superfamily Domains in Cell Adhesion Molecules and Surface Receptors Belong to a New Structural Set Which is close to That Containing Variable Domains

1994 • 439 citations

An adenovirus type 2 glycoprotein blocks cell surface expression of human histocompatibility class I antigens

1985 • 405 citations

Identification of four subsets of human CD3-CD16+ natural killer (NK) cells by the expression of clonally distributed functional surface molecules: correlation between subset assignment of NK clones and ability to mediate specific alloantigen recognition.

1990 • 388 citations

Development of human T and natural killer cells

1995 • 379 citations

The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer.

1996 • 365 citations

Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases.

1996 • 362 citations

Interferon gamma production by natural killer (NK) cells and NK1.1+ T cells upon NKR-P1 cross-linking.

1996 • 349 citations

A human killer inhibitory receptor specific for HLA-A1,2.

1996 • 347 citations

NKB1: a natural killer cell receptor involved in the recognition of polymorphic HLA-B molecules.

1994 • 343 citations

Protection from lysis by natural killer cells of group 1 and 2 specificity is mediated by residue 80 in human histocompatibility leukocyte antigen C alleles and also occurs with empty major histocompatibility complex molecules.

1996 • 340 citations

Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer

1995 • 338 citations

The human leukocyte antigen (HLA)-C-specific "activatory" or "inhibitory" natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions.

1996 • 337 citations

NK3-specific natural killer cells are selectively inhibited by Bw4-positive HLA alleles with isoleucine 80.

1994 • 337 citations

Impaired intracellular transport of class I MHC antigens as a possible means for adenoviruses to evade immune surveillance

1985 • 322 citations

Superantigen-Dependent, Cell-Mediated Cytotoxicity Inhibited by MHC Class I Receptors on T Lymphocytes

1995 • 316 citations

Immunocytochemical characterization of the unusual large granular lymphocytes in human endometrium throughout the menstrual cycle

1989 • 314 citations

Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes.

1995 • 309 citations

Peptide Specificity in the Recognition of MHC Class I by Natural Killer Cell Clones

1995 • 308 citations

Production of human cells expressing individual transferred HLA-A,-B,-C genes using an HLA-A,-B,-C null human cell line.

1989 • 305 citations

Cell populations in human early pregnancy decidua: characterization and isolation of large granular lymphocytes by flow cytometry.

1988 • 284 citations

Identification of a common T/natural killer cell progenitor in human fetal thymus.

1994 • 280 citations

Multiple independent loci within the human cytomegalovirus unique short region down-regulate expression of major histocompatibility complex class I heavy chains

1995 • 278 citations

HLA-A11 Epitope Loss Isolates of Epstein-Barr Virus From a Highly A11 ⁺ Population

1993 • 255 citations

A complex between the MHC class I homologue encoded by human cytomegalovirus and β2 microglobulin

1990 • 246 citations

Generation of Allospecific Natural Killer Cells by Stimulation Across a Polymorphism of HLA-C

1993 • 241 citations

Human T-cell clones recognize chemically synthesized peptides of influenza haemagglutinin

1982 • 224 citations

Amino acid substitutions can influence the natural killer (NK)-mediated recognition of HLA-C molecules. Role of serine-77 and lysine-80 in the target cell protection from lysis mediated by "group 2" or "group 1" NK clones.

1995 • 216 citations

Human cytomegalovirus down-regulates HLA class I expression by reducing the stability of class I H chains.

1993 • 215 citations

Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein tyrosine phosphatase 1C.

1996 • 213 citations

Tyrosine phosphorylation of a human killer inhibitory receptor recruits protein tyrosine phosphatase 1C.

1996 • 210 citations

Cytomegalovirus prevents antigen presentation by blocking the transport of peptide-loaded major histocompatibility complex class I molecules into the medial-Golgi compartment.

1992 • 204 citations

Molecular Phylogeny of the Alphaherpesvirinae Subfamily and a Proposed Evolutionary Timescale

1994 • 197 citations

Evidence of a natural killer (NK) cell repertoire for (allo) antigen recognition: definition of five distinct NK-determined allospecificities in humans.

1992 • 190 citations

CD94 and a Novel Associated Protein (94AP) Form a NK Cell Receptor Involved in the Recognition of HLA-A, HLA-B, and HLA-C Allotypes

1996 • 187 citations

Binding of diverse peptides to MHC class I molecules inhibits target cell lysis by activated natural killer cells

1995 • 180 citations

Specificity of HLA class I antigen recognition by human NK clones: evidence for clonal heterogeneity, protection by self and non-self alleles, and influence of the target cell type.

1993 • 178 citations

Alloantigen recognition by two human natural killer cell clones is associated with HLA-C or a closely linked gene.

1992 • 157 citations

The MHC class I homolog encoded by human cytomegalovirus binds endogenous peptides

1995 • 144 citations

T cell clones expressing the natural killer cell‐related p58 receptor molecule display heterogeneity in phenotypic properties and p58 function

1994 • 140 citations

A novel functional cell surface dimer (Kp43) expressed by natural killer cells and T cell receptor-gamma/delta+ T lymphocytes. I. Inhibition of the IL-2-dependent proliferation by anti-Kp43 monoclonal antibody.

1990 • 136 citations

Allele-specific peptide ligand motifs of HLA-C molecules.

1993 • 128 citations

Functional ambivalence of the Kp43 (CD94) NK cell-associated surface antigen.

1995 • 124 citations

Regulation of T cell lymphokine production by killer cell inhibitory receptor recognition of self HLA class I alleles.

1996 • 109 citations

Human Cytomegalovirus Inhibits Peptide Translocation into the Endoplasmic Reticulum for MHC Class I Assembly

1996 • 101 citations

Specific recognition of human CD3-CD16+ natural killer cells requires the expression of an autosomic recessive gene on target cells.

1990 • 92 citations

The NKB1 and HP-3E4 NK cells receptors are structurally distinct glycoproteins and independently recognize polymorphic HLA-B and HLA-C molecules.

1995 • 82 citations

Coexpression of two functionally independent p58 inhibitory receptors in human natural killer cell clones results in the inability to kill all normal allogeneic target cells.

1995 • 65 citations

A novel functional cell surface dimer (Kp43) expressed by natural killer cells and gamma/delta TCR+ T lymphocytes. II. Modulation of natural killer cytotoxicity by anti-Kp43 monoclonal antibody.

1991 • 61 citations

Threonine 80 on HLA‐B27 confers protection against lysis by a group of natural killer clones

1996 • 60 citations

Inhibition of gamma delta T cell recognition by receptors for MHC class I molecules.

1995 • 50 citations

MHC gene in cytomegalovirus

1988 • 21 citations

Monosodium Glutamate: Specific Brain Lesion Questioned

1970 • 18 citations