Prooxidant effects of β-carotene in cultured cells

The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers

1994 • 4,626 citations

Effects of a Combination of Beta Carotene and Vitamin A on Lung Cancer and Cardiovascular Disease

1996 • 3,608 citations

β-Carotene: an Unusual Type of Lipid Antioxidant

1984 • 2,147 citations

Antioxidant and redox regulation of gene transcription

1996 • 1,999 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

Vitamins E and C, beta-carotene, and other carotenoids as antioxidants

1995 • 1,072 citations

Oxidative stress and nuclear factor-κB activation

2000 • 865 citations

Beta‐carotene, carotenoids, and disease prevention in humans

1996 • 862 citations

Antioxidant and Prooxidant Properties of Carotenoids

2001 • 781 citations

[38] Antioxidant effects of carotenoids in Vivo and in Vitro: An overview

1992 • 485 citations

Actions of Carotenoids in Biological Systems

1993 • 438 citations

Consumption of vegetables reduces genetic damage in humans: first results of a human intervention trial with carotenoid-rich foods

1997 • 421 citations

β-Carotene and α-tocopherol are synergistic antioxidants

1992 • 413 citations

NF-κB as a primary regulator of the stress response

1999 • 407 citations

Retinoid Signaling and Activator Protein-1 Expression in Ferrets Given -Carotene Supplements and Exposed to Tobacco Smoke

1999 • 363 citations

Nutrition and lung cancer

1996 • 346 citations

Carotenoids up-regulate connexin43 gene expression independent of their provitamin A or antioxidant properties.

1992 • 330 citations

Prooxidant Actions of Carotenoids in Biologic Systems

2009 • 327 citations

Vitamin A and β-Carotene Can Improve Nonheme Iron Absorption from Rice, Wheat and Corn by Humans

1998 • 293 citations

Differential regulation of the c-myc oncogene promoter by the NF-kappa B rel family of transcription factors.

1994 • 280 citations

Effect of β-Carotene and Canthaxanthin on the Immune Responses of the Rat

1986 • 272 citations

Redox signalling by transcription factors NF-κB and AP-1 in lymphocytes

1995 • 258 citations

Lycopene andβ-carotene protect against oxidative damage in HT29 cells at low concentrations but rapidly lose this capacity at higher doses

1999 • 207 citations

Oxidative DNA Damage by Vitamin A and Its Derivative via Superoxide Generation

2000 • 186 citations

Carotenoids and genomic stability

2001 • 147 citations

Ascorbic acid and beta-carotene as modulators of oxidative damage

1997 • 142 citations

Dietary Supplements of Vitamin E, β-Carotene, Coenzyme Q10 and Selenium Protect Tissues Against Lipid Peroxidation in Rat Tissue Slices

1990 • 130 citations

β-Carotene Regulates NF-κB DNA-Binding Activity by a Redox Mechanism in Human Leukemia and Colon Adenocarcinoma Cells

2003 • 129 citations

Antioxidant and Prooxidant Role of β-Carotene in Murine Normal and Tumor Thymocytes: Effects of Oxygen Partial Pressure

1997 • 127 citations

Induction of cell cycle arrest and apoptosis in human colon adenocarcinoma cell lines by beta-carotene through down-regulation of cyclin A and Bcl-2 family proteins

2002 • 121 citations

β-carotene at high concentrations induces apoptosis by enhancing oxy-radical production in human adenocarcinoma cells

2001 • 118 citations

Induction of cytochrome P450 enzymes and over-generation of oxygen radicals in beta-carotene supplemented rats

2001 • 97 citations

Prooxidant activity of β-carotene under 100% oxygen pressure in rat liver microsomes

1995 • 97 citations

DNA strand breakage and oxygen tension: effects of β-carotene, α-tocopherol and ascorbic acid

2001 • 93 citations

Antioxidant and pro-oxidant effects of lycopene in comparison with β-carotene on oxidant-induced damage in Hs68 cells

2000 • 87 citations

Enhancement of the UVA induction of haem oxygenase‐1 expression by β‐carotene in human skin fibroblasts

1999 • 85 citations

Protection of vitamin E, selenium, trolox C, ascorbic acid palmitate, acetylcysteine, coenzyme Q0, coenzyme Q10, beta-carotene, canthaxanthin, and (+)-catechin against oxidative damage to rat blood and tissues in vivo

1995 • 85 citations

β-Carotene and protein oxidation: effects of ascorbic acid and α-tocopherol

2000 • 84 citations

The effectiveness of a mixture of β‐carotene, α‐tocopherol, glutathione, and ascorbic acid for cancer prevention

1993 • 83 citations

Excentric Cleavage Products of β-Carotene Inhibit Estrogen Receptor Positive and Negative Breast Tumor Cell Growth In Vitro and Inhibit Activator Protein-1-Mediated Transcriptional Activation

2002 • 68 citations

Effects of Dietary α‐Tocopherol and β‐Carotene on Lipid Peroxidation Induced by Methyl Mercuric Chloride in Mice

1993 • 67 citations

β‐Carotene enhances hydrogen peroxide‐induced DNA damage in human hepatocellular HepG2 Cells

1999 • 66 citations

Regulation of cell cycle progression and apoptosis by β‐carotene in undifferentiated and differentiated HL‐60 leukemia cells: Possible involvement of a redox mechanism

2001 • 64 citations

β-Carotene as enhancer of cell transforming activity of powerful carcinogens and cigarette-smoke condensate on BALB/c 3T3 cells in vitro

1999 • 59 citations

Prooxidant and antioxidant reaction mechanisms of carotene and radical interactions with vitamins E and C

1997 • 56 citations

Induction of a 70kD protein associated with the selective cytotoxicity of beta-carotene in human epidermal carcinoma

1990 • 54 citations

Induction of oxidative DNA damage in human foreskin fibroblast Hs68 cells by oxidizedβ-carotene and lycopene

2001 • 47 citations

Regulation of the human cellular glutathione peroxidase gene during in vitro myeloid and monocytic differentiation

1994 • 35 citations

Role of gene regulation in the anticancer activity of carotenoids

2002 • 33 citations

Retinoblastoma protein dephosphorylation is an early event of cellular response to prooxidant conditions

2000 • 33 citations

Design, synthesis, and antioxidant activity of FeAOX-6, a novel agent deriving from a molecular combination of the chromanyl and polyisoprenyl moieties

2002 • 31 citations

Modulation of oxidative stress by β-carotene in chicken embryo fibroblasts

1995 • 31 citations

Effect of β-carotene on clastogenic effects of mitomycin C, methyl methanesulphonate and bleomycin in Chinese hamster ovary cells

1994 • 30 citations

Re-appraisal of the Tocopheroxyl Radical Reaction with β-Carotene: Evidence for Oxidation of Vitamin E by the β-Carotene Radical Cation

1998 • 29 citations

[22] In Vitro biological methods for determination of carotenoid activity

1993 • 28 citations

Beta-carotene in vitro stimulates tumor necrosis factor alpha and interleukin 1 alpha secretion by human peripheral blood mononuclear cells

1993 • 22 citations

Growth suppression and induction of heat-shock protein-70 by 9-cis β-carotene in cervical dysplasia-derived cells

1997 • 22 citations

Modulation of paraquat toxicity by β-carotene at low oxygen partial pressure in chicken embryo fibroblasts

1997 • 13 citations

Antioxidant and prooxidant effects of β-carotene and lycopene on oxidant-induced damage in Hs68 cells.

2001 • 2 citations