Prooxidant Actions of Carotenoids in Biologic Systems

The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers

1994 • 4,626 citations

Effects of a Combination of Beta Carotene and Vitamin A on Lung Cancer and Cardiovascular Disease

1996 • 3,608 citations

Bilirubin Is an Antioxidant of Possible Physiological Importance

1987 • 3,406 citations

Lack of Effect of Long-Term Supplementation with Beta Carotene on the Incidence of Malignant Neoplasms and Cardiovascular Disease

1996 • 2,429 citations

β-Carotene: an Unusual Type of Lipid Antioxidant

1984 • 2,147 citations

Persistent oxidative stress in cancer

1995 • 1,218 citations

Vitamins E and C, beta-carotene, and other carotenoids as antioxidants

1995 • 1,072 citations

Beta‐carotene, carotenoids, and disease prevention in humans

1996 • 862 citations

Chemistry of singlet oxygen. VII. Quenching by .beta.-carotene

1968 • 636 citations

Lycopene is a more potent inhibitor of human cancer cell proliferation than either α‐carotene or β‐carotene

1995 • 517 citations

[38] Antioxidant effects of carotenoids in Vivo and in Vitro: An overview

1992 • 485 citations

Interaction among vitamin C, vitamin E, and beta-carotene

1995 • 460 citations

Actions of Carotenoids in Biological Systems

1993 • 438 citations

β-Carotene and α-tocopherol are synergistic antioxidants

1992 • 413 citations

Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro

1996 • 377 citations

Carotenoids up-regulate connexin43 gene expression independent of their provitamin A or antioxidant properties.

1992 • 330 citations

Intestinal absorption, serum clearance, and interactions between lutein and beta-carotene when administered to human adults in separate or combined oral doses

1995 • 312 citations

Vitamins A, E, and carotene: effects of supplementation on their plasma levels

1983 • 285 citations

Effect of β-Carotene and Canthaxanthin on the Immune Responses of the Rat

1986 • 272 citations

Characterization of products formed during the autoxidation of β-carotene

1991 • 231 citations

Preservation of the endogenous antioxidants in low density lipoprotein by ascorbate but not probucol during oxidative modification.

1991 • 228 citations

Mortality associated with low plasma concentration of beta carotene and the effect of oral supplementation

1996 • 228 citations

Antioxidant activity of xanthophylls on peroxyl radical-mediated phospholipid peroxidation

1992 • 228 citations

Peroxyl radical scavenging by beta-carotene in lipid bilayers. Effect of oxygen partial pressure.

1992 • 204 citations

Carotenoids and cancer: An update with emphasis on human intervention studies

1993 • 194 citations

The Dual Roles of Nutrients as Antioxidants and Prooxidants: Their Effects on Tumor Cell Growth

1996 • 155 citations

The inhibition of radical-initiated peroxidation of microsomal lipids by both α-tocopherol and β-carotene

1991 • 153 citations

Antioxidant Reactions of β-Carotene: Identification of Carotenoid−Radical Adducts

1996 • 151 citations

Effects of Lutein, Lycopene, Annatto, and γ-Tocopherol on Autoxidation of Triglycerides

1996 • 148 citations

Peroxyl radical oxidation of .beta.-carotene: formation of .beta.-carotene epoxides

1991 • 143 citations

Inhibitory effects of fucoxanthin, a natural carotenoid, on N-myc expression and cell cycle progression in human malignant tumor cells

1990 • 138 citations

Dietary Supplements of Vitamin E, β-Carotene, Coenzyme Q10 and Selenium Protect Tissues Against Lipid Peroxidation in Rat Tissue Slices

1990 • 130 citations

Inhibition of adriamycin‐promoted microsomal lipid peroxidation by β‐carotene, α‐tocopherol and retinol at high and low oxygen partial pressures

1988 • 128 citations

Interactions between Carotenoids and the CCl3O2.bul. Radical

1995 • 127 citations

Antioxidant and Prooxidant Role of β-Carotene in Murine Normal and Tumor Thymocytes: Effects of Oxygen Partial Pressure

1997 • 127 citations

Prooxidant activity of β-carotene under 100% oxygen pressure in rat liver microsomes

1995 • 97 citations

Beta-carotene, vitamin E and vitamin C in different stages of experimental carcinogenesis.

1995 • 96 citations

Reduction in plasma or Skin Alpha Tocopherol Concentration With Long-term Oral Administration of Beta-carottene in Humans and Mice

1992 • 91 citations

Beta-carotene induces morphological differentiation and decreases adenylate cyclase activity in melanoma cells in culture.

1990 • 89 citations

Pharmacokinetics of beta-carotene and canthaxanthin after ingestion of individual and combined doses by human subjects.

1994 • 88 citations

Canthaxanthin induces apoptosis in human cancer cell lines

1998 • 85 citations

Protection of vitamin E, selenium, trolox C, ascorbic acid palmitate, acetylcysteine, coenzyme Q0, coenzyme Q10, beta-carotene, canthaxanthin, and (+)-catechin against oxidative damage to rat blood and tissues in vivo

1995 • 85 citations

β-carotene and disease: a suggested pro-oxidant and anti-oxidant mechanism and speculations concerning its role in cigarette smoking

1996 • 84 citations

The effectiveness of a mixture of β‐carotene, α‐tocopherol, glutathione, and ascorbic acid for cancer prevention

1993 • 83 citations

Dietary supplementation with carotenoids: effects on α-tocopherol levels and susceptibility of tissues to oxidative stress

1996 • 83 citations

INHIBITORY EFFECTS OF TOCOPHEROLS AND ?-CAROTENE ON SINGLET OXYGEN-INITIATE D PHOTOOXIDATION OF METHYL LINOLEATE AND SOYBEAN OIL

1980 • 81 citations

Antioxidant Actions of β-Carotene in Liposomal and Microsomal Membranes: Role of Carotenoid-Membrane Incorporation and α-Tocopherol

1997 • 78 citations

Antioxidant Action of Carotenoids in Vitro and in Vivo and Protection against Oxidation of Human Low‐Density Lipoproteinsa,b

1993 • 78 citations

Susceptibility of human LDL to oxidative modification. Effects of variations in beta-carotene concentration and oxygen tension.

1994 • 76 citations

Growth retardation in human cervical dysplasia-derived cell lines by beta-carotene through down-regulation of epidermal growth factor receptor

1995 • 73 citations

Effects of Dietary α‐Tocopherol and β‐Carotene on Lipid Peroxidation Induced by Methyl Mercuric Chloride in Mice

1993 • 67 citations

Changes in serum carotenoids in subjects with colorectal adenomas after 24 mo ofβ-carotene supplementation

1994 • 64 citations

Action of β-Carotene on Purified Rapeseed Oil During Light Storage

1994 • 64 citations

Antioxidant activity of dietary canthaxanthin

1989 • 60 citations

Induction of a 70kD protein associated with the selective cytotoxicity of beta-carotene in human epidermal carcinoma

1990 • 54 citations

The effect of long-term beta-carotene and vitamin A administration on serum concentrations of alpha-tocopherol.

1994 • 48 citations

The protective but nonsynergistic effect of dietary β‐carotene and vitamin E on skin tumorigenesis in Skh mice

1994 • 47 citations

Lipid Peroxide, α-Tocopherol and Retinoid Levels in Plasma and Liver of Rats Fed Diets Containing β-Carotene and 13-cis-Retinoic Acid

1983 • 45 citations

Steady-State Serum Concentration of Alpha Tocopherol Not Altered by Supplementation With Oral Beta Carotene

1994 • 43 citations

Interactions of oral beta-carotene and canthaxanthin in ferrets.

1993 • 41 citations

Effects of β-Carotene and Retinyl Palmitate on Corn Oil-Induced Superoxide Dismutase and Catalase in Rats

1988 • 39 citations

GGT reduction in beta carotene-inhibition of hamster buccal pouch carcinogenesis

1987 • 35 citations

Influence of combined antioxidant nutrient intakes on their plasma concentrations in an elderly population

1995 • 34 citations

beta-Carotene supplementation results in an increased serum and colonic mucosal concentration of beta-carotene and a decrease in alpha-tocopherol concentration in patients with colonic neoplasia.

1994 • 32 citations

Canthaxanthin and Excess Vitamin A Alter α-Tocopherol, Carotenoid and Iron Status in Adult Rats

1991 • 31 citations

Supplementing Ferrets with Canthaxanthin Affects the Tissue Distributions of Canthaxanthin, Other Carotenoids, Vitamin A and Vitamin E

1995 • 27 citations

The effect of dietary vitamin E and ß-carotene on oxidation processes in the rat testis

1991 • 22 citations

Beta-carotene in vitro stimulates tumor necrosis factor alpha and interleukin 1 alpha secretion by human peripheral blood mononuclear cells

1993 • 22 citations

No effect of β-carotene supplementation on plasma lipoproteins in healthy smokers

1994 • 22 citations

Supplementation with Canthaxanthin Affects Plasma and Tissue Distribution of α- and γ-Tocopherols in Mice

1998 • 19 citations

In vitro and in vivo effects of beta-carotene on rat epidermal lipoxygenases.

1997 • 19 citations

Antitumor effect of an oral administration of canthaxanthin on BALB/c mice bearing thymoma cells

1997 • 8 citations