Normal timing of oligodendrocyte development depends on thyroid hormone receptor alpha 1 (TRalpha1)

The c-erb-A gene encodes a thyroid hormone receptor

1986 • 1,505 citations

The c-erb-A protein is a high-affinity receptor for thyroid hormone

1986 • 1,340 citations

Cell death and control of cell survival in the oligodendrocyte lineage

1992 • 1,331 citations

Single factors direct the differentiation of stem cells from the fetal and adult central nervous system.

1996 • 1,164 citations

Thyroid Hormone Receptors: Multiple Forms, Multiple Possibilities*

1993 • 1,009 citations

Development of oligodendrocytes and Schwann cells studied with a monoclonal antibody against galactocerebroside.

1982 • 842 citations

Galactocerebroside is a specific cell-surface antigenic marker for oligodendrocytes in culture

1978 • 813 citations

Differential Recognition of Target Genes by Nuclear Receptor Monomers, Dimers, and Heterodimers*

1994 • 789 citations

Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture

1988 • 760 citations

A novel role for thyroid hormone, glucocorticoids and retinoic acid in timing oligodendrocyte development

1994 • 585 citations

Spatial and temporal expression of alpha- and beta-thyroid hormone receptor mRNAs, including the beta 2-subtype, in the developing mammalian nervous system

1992 • 536 citations

Abnormal heart rate and body temperature in mice lacking thyroid hormone receptor alpha 1

1998 • 503 citations

Thyroid Hormones and Brain Development

1987 • 497 citations

Identification of a tHyroid Hormone Receptor That Is Pituitary-Specific

1989 • 493 citations

Regulation of cell proliferation by the E2F transcription factors

1998 • 486 citations

Identification of an adult-specific glial progenitor cell

1989 • 476 citations

Evidence for migration of oligodendrocyte–type-2 astrocyte progenitor cells into the developing rat optic nerve

1987 • 471 citations

Clonal analysis of oligodendrocyte development in culture: Evidence for a developmental clock that counts cell divisions

1986 • 456 citations

Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation

1999 • 442 citations

Inhibition of thyroid hormone action by a non-hormone binding c-erbA protein generated by alternative mRNA splicing

1989 • 437 citations

Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor beta: evidence for tissue-specific modulation of receptor function.

1996 • 432 citations

Mechanism of corepressor binding and release from nuclear hormone receptors

1999 • 414 citations

Different functions for the thyroid hormone receptors TRalpha and TRbeta in the control of thyroid hormone production and post-natal development

1999 • 411 citations

Proliferating bipotential glial progenitor cells in adult rat optic nerve

1986 • 378 citations

Electron microscopic autoradiographic studies of gliogenesis in rat optic nerve I. Cell proliferation

1976 • 364 citations

Thyroid hormone receptor β is essential for development of auditory function

1996 • 363 citations

The T3Ralpha gene encoding a thyroid hormone receptor is essential for post-natal development and thyroid hormone production

1997 • 341 citations

[6] The growth of cells in serum-free hormone-supplemented media

1979 • 330 citations

Nuclear receptor coregulators: multiple modes of modification

2002 • 323 citations

A quantitative immunohistochemical study of macroglial cell development in the rat optic nerve: In vivo evidence for two distinct astrocyte lineages

1985 • 316 citations

Electron microscopic autoradiographic studies of gliogenesis in rat optic nerve. II. Time of origin

1976 • 315 citations

Contrasting developmental and tissue-specific expression of alpha and beta thyroid hormone receptor genes.

1990 • 308 citations

Alternative splicing generates messages encoding rat c-erbA proteins that do not bind thyroid hormone.

1988 • 300 citations

Reconstitution of a developmental clock in vitro: a critical role for astrocytes in the timing of oligodendrocyte differentiation

1985 • 296 citations

Thyroid hormone receptors: multiple forms, multiple possibilities

1993 • 291 citations

Cloning and Characterization of Two Novel Thyroid Hormone Receptor β Isoforms

2000 • 276 citations

Genetic Analysis Reveals Different Functions for the Products of the Thyroid Hormone Receptor α Locus

2001 • 256 citations

Identification of a Rat c-erbAα-Related Protein Which Binds Deoxyribonucleic Acid but does not Bind Thyroid Hormone

1988 • 254 citations

Isolation and characterization of rat cDNA clones for two distinct thyroid hormone receptors.

1988 • 237 citations

Lack of Replicative Senescence in Cultured Rat Oligodendrocyte Precursor Cells

2001 • 229 citations

An unliganded thyroid hormone receptor causes severe neurological dysfunction

2001 • 227 citations

Isolation of a cDNA clone encoding a biologically active thyroid hormone receptor.

1988 • 225 citations

Deletion of the thyroid hormone receptor α1 prevents the structural alterations of the cerebellum induced by hypothyroidism

2002 • 217 citations

The Id4 HLH protein and the timing of oligodendrocyte differentiation

2000 • 196 citations

Differential recognition of target genes by nuclear receptor monomers, dimers, and heterodimers

1994 • 174 citations

Congenital Hypothyroid Pax8−/− Mutant Mice Can Be Rescued by Inactivating the TRα Gene

2002 • 171 citations

Identification of Transcripts Initiated from an Internal Promoter in the c-erbAα Locus That Encode Inhibitors of Retinoic Acid Receptor-α and Triiodothyronine Receptor Activities

1997 • 167 citations

Neonatal hypothyroidism affects the timely expression of myelin-associated glycoprotein in the rat brain.

1993 • 158 citations

Basic helix-loop-helix proteins and the timing of oligodendrocyte differentiation

2000 • 155 citations

Increased sensitivity to thyroid hormone in mice with complete deficiency of thyroid hormone receptor alpha

2000 • 155 citations

Functional Interference between Thyroid Hormone Receptor α (TRα) and Natural Truncated TRΔα Isoforms in the Control of Intestine Development

2001 • 140 citations

Retardation of Cochlear Maturation and Impaired Hair Cell Function Caused by Deletion of All Known Thyroid Hormone Receptors

2001 • 135 citations

Basic Transcription Element-binding Protein (BTEB) Is a Thyroid Hormone-regulated Gene in the Developing Central Nervous System

1999 • 124 citations

Thyroid hormone affects Schwann cell and oligodendrocyte gene expression at the glial transition zone of the VIIIth nerve prior to cochlea function

1998 • 124 citations

Oligodendrocyte precursor cells count time but not cell divisions before differentiation

1997 • 122 citations

Effects of Altered Thyroid States on Myelinogenesis

1981 • 118 citations

Dominant negative activity of an endogenous thyroid hormone receptor variant (alpha 2) is due to competition for binding sites on target genes.

1993 • 118 citations

Evidence for the Existence of at Least Two Timing Mechanisms That Contribute to Oligodendrocyte Generationin Vitro

1996 • 114 citations

Role of Thyroid Hormone Receptors in Timing Oligodendrocyte Differentiation

2001 • 112 citations

Beta 1 isoform-specific regulation of a triiodothyronine-induced gene during cerebellar development.

1992 • 109 citations

Cell-Intrinsic Timers and Thyroid Hormone Regulate the Probability of Cell-Cycle Withdrawal and Differentiation of Oligodendrocyte Precursor Cells

1998 • 107 citations

Triiodothyronine Stimulation of Oligodendroglial Differentiation and Myelination

1985 • 106 citations

Effects of Thyroid Hormone on Embryonic Oligodendrocyte Precursor Cell Developmentin Vivoandin Vitro

1997 • 99 citations

Persistence of oligodendrocyte precursor cells and altered myelination in optic nerve associated to retina degeneration in mice devoid of all thyroid hormone receptors

2002 • 88 citations

Assignment of the beta-thyroid hormone receptor to 3,5,3'-triiodothyronine-dependent inhibition of transcription from the thyrotropin-releasing hormone promoter in chick hypothalamic neurons.

1992 • 87 citations

Two molecularly distinct intracellular pathways to oligodendrocyte differentiation: role of a p53 family protein

2001 • 76 citations

Sustained neonatal hyperthyroidism in the rat affects myelination in the central nervous system

1998 • 73 citations

Isolation and Characterization of Mouse Complementary DNAs Encoding α and β Thyroid Hormone Receptors from Thyrotrope Cells: The Mouse Pituitary-Specific β2 Isoform Differs at the Amino Terminus from the Corresponding Species fromRat Pituitary Tumor Cells

1991 • 73 citations

Hormone-Dependent Repression of the E2F-1 Gene by Thyroid Hormone Receptors

2003 • 73 citations

Dominant negative inhibition by mutant thyroid hormone receptors is thyroid hormone response element and receptor isoform specific.

1993 • 66 citations

Immunofluorescent localization of thyroid hormone receptor isoforms in glial cells of rat brain.

1994 • 60 citations

Effects of triiodothyronine on the synthesis of sulfolipids by oligodendrocyte-enriched glial cultures

1986 • 52 citations

Measurement of Time in Oligodendrocyte-Type-2 Astrocyte (O-2A) Progenitors Is a Cellular Process Distinct from Differentiation or Division

1994 • 51 citations

Suppression of the deafness and thyroid dysfunction in Thrb-null mice by an independent mutation in the Thra thyroid hormone receptor alpha gene

2001 • 50 citations

Thyroid hormone receptor isoforms are sequentially expressed in oligodendrocyte lineage cells during rat cerebral development

1998 • 48 citations

Thyroid Hormones And Brain Development

1987 • 43 citations

Expression of thyroid hormone receptor isoforms in rat oligodendrocyte cultures. Effect of 3,5,3′-triiodo-l-thyronine

1994 • 36 citations

Increased sensitivity to thyroid hormone in mice with complete deficiency of thyroid hormone receptor alpha

2001 • 27 citations

Expression of α and β thyroid receptors during oligodendrocyte differentiation

1994 • 24 citations

Dominant negative activity of thyroid hormone receptor variant α2 and interaction with nuclear corepressors

1999 • 22 citations

Three different thyroid hormone receptor isoforms are detected in a pure culture of ovine oligodendrocytes

1995 • 21 citations

Transcriptional repression by nuclear receptors: mechanisms and role in disease

2000 • 16 citations

Thyroid hormone receptor isoforms are sequentially expressed in oligodendrocyte lineage cells during rat cerebral development

1998 • 2 citations

Expression of thyroid hormone receptor isoforms in rat oligodendrocyte cultures. Effect of 3,5,3'-triiodo-L-thyronine.

1994 • 1 citations