Deletion of the thyroid hormone receptor α1 prevents the structural alterations of the cerebellum induced by hypothyroidism

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Molecular cloning: A laboratory manual

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The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

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1996 • 864 citations

Spatial and temporal expression of alpha- and beta-thyroid hormone receptor mRNAs, including the beta 2-subtype, in the developing mammalian nervous system

1992 • 536 citations

Abnormal heart rate and body temperature in mice lacking thyroid hormone receptor alpha 1

1998 • 503 citations

Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation

1999 • 442 citations

Inhibition of thyroid hormone action by a non-hormone binding c-erbA protein generated by alternative mRNA splicing

1989 • 437 citations

Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor beta: evidence for tissue-specific modulation of receptor function.

1996 • 432 citations

Thyroid hormone receptor α isoforms generated by alternative splicing differentially activate myosin HC gene transcription

1988 • 425 citations

Different functions for the thyroid hormone receptors TRalpha and TRbeta in the control of thyroid hormone production and post-natal development

1999 • 411 citations

Repression of transcription mediated at a thyroid hormone response element by the v-erb-A oncogene product

1989 • 387 citations

Thyroid hormone receptor β is essential for development of auditory function

1996 • 363 citations

Neurobehavioral teratology

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Relationship of c-erbA mRNA content to tissue triiodothyronine nuclear binding capacity and function in developing and adult rats.

1990 • 298 citations

Transcriptional Repression by Nuclear Hormone Receptors

2000 • 291 citations

Cloning and Characterization of Two Novel Thyroid Hormone Receptor β Isoforms

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A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor

1998 • 267 citations

Nongenomic Actions of Thyroid Hormone

1996 • 257 citations

Genetic Analysis Reveals Different Functions for the Products of the Thyroid Hormone Receptor α Locus

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Thyroid hormone–sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform–specific

2001 • 256 citations

Cell-cell interactions influence survival and differentiation of purified purkinje cells in vitro

1994 • 252 citations

Only the combined treatment with thyroxine and triiodothyronine ensures euthyroidism in all tissues of the thyroidectomized rat.

1996 • 245 citations

The Thyroid Hormone Receptor-β-Selective Agonist GC-1 Differentially Affects Plasma Lipids and Cardiac Activity¹

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Independent Expression of the α and β c-erbA Genes in Developing Rat Brain

1991 • 195 citations

Cardiac Ion Channel Expression and Contractile Function in Mice with Deletion of Thyroid Hormone Receptor α or β**This work was supported by Grant HL-25022 (to W.H.D.) and by operating grants from the Canadian Medical Research Council and the Heart and Stroke Foundation of Canada (to W.G. and R.C.).

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Identification of Transcripts Initiated from an Internal Promoter in the c-erbAα Locus That Encode Inhibitors of Retinoic Acid Receptor-α and Triiodothyronine Receptor Activities

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Increased sensitivity to thyroid hormone in mice with complete deficiency of thyroid hormone receptor alpha

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Distinct functions for thyroid hormone receptors alpha and beta in brain development indicated by differential expression of receptor genes.

1991 • 149 citations

Functional Interference between Thyroid Hormone Receptor α (TRα) and Natural Truncated TRΔα Isoforms in the Control of Intestine Development

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Cell-specific effects of thyroid hormone on RC3/neurogranin expression in rat brain.

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Selective modulation of thyroid hormone receptor action

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The Regulatory Connection between the Activity of Granule Cell NMDA Receptors and Dendritic Differentiation of Cerebellar Purkinje Cells

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Effect of thyroid deficiency on the synaptic organization of the rat cerebellar cortex

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Widespread distribution of immunoreactive thyroid hormone beta 2 receptor (TR beta 2) in the nuclei of extrapituitary rat tissues.

1994 • 106 citations

Brain glucose utilization in mice with a targeted mutation in the thyroid hormone α or β receptor gene

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Thyroid hormone–sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform–specific

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Thyroid Hormone Receptor Gene Knockouts

1998 • 57 citations

Isoform-specific 3,5,3'-triiodothyronine receptor binding capacity and messenger ribonucleic acid content in rat adenohypophysis: effect of thyroidal state and comparison with extrapituitary tissues.

1996 • 54 citations

Expression of peptides and other neurochemical markers in hypothalamus and olfactory bulb of mice devoid of all known thyroid hormone receptors

2000 • 40 citations

Increased sensitivity to thyroid hormone in mice with complete deficiency of thyroid hormone receptor alpha

2001 • 27 citations

Increased sensitivity to thyroid hormone in mice with complete deficiency of thyroid hormone receptor α

2000 • 19 citations