A novel role for thyroid hormone, glucocorticoids and retinoic acid in timing oligodendrocyte development

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

1991 • 3,396 citations

A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium

1983 • 2,009 citations

Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction

1990 • 1,583 citations

Cell death and control of cell survival in the oligodendrocyte lineage

1992 • 1,331 citations

Transcription Factor Interactions: Selectors of Positive or Negative Regulation from a Single DNA Element

1990 • 1,326 citations

Thyroid Hormone Receptors: Multiple Forms, Multiple Possibilities*

1993 • 1,009 citations

Monoclonal antibody to a plasma membrane antigen of neurons.

1979 • 965 citations

Bone and haematopoietic defects in mice lacking c-fos

1992 • 939 citations

Retinoids and their receptors in differentiation, embryogenesis, and neoplasia

1991 • 856 citations

Development of oligodendrocytes and Schwann cells studied with a monoclonal antibody against galactocerebroside.

1982 • 842 citations

Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture

1988 • 760 citations

Multiple extracellular signals are required for long-term oligodendrocyte survival

1993 • 707 citations

Pleiotropic effects of a null mutation in the c-fos proto-oncogene

1992 • 643 citations

Developmental Neuropathology

1989 • 591 citations

Retinoic acid is a negative regulator of AP-1-responsive genes.

1991 • 542 citations

Spatial and temporal expression of alpha- and beta-thyroid hormone receptor mRNAs, including the beta 2-subtype, in the developing mammalian nervous system

1992 • 536 citations

Thyroid Hormones and Brain Development

1987 • 497 citations

Identification of a tHyroid Hormone Receptor That Is Pituitary-Specific

1989 • 493 citations

CNTF Protection of Oligodendrocytes Against Natural and Tumor Necrosis Factor-Induced Death

1993 • 486 citations

Repression of c- fos Transcription and an Altered Genetic Program in Senescent Human Fibroblasts

1990 • 478 citations

Clonal analysis of oligodendrocyte development in culture: Evidence for a developmental clock that counts cell divisions

1986 • 456 citations

Inhibition of thyroid hormone action by a non-hormone binding c-erbA protein generated by alternative mRNA splicing

1989 • 437 citations

A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture.

1993 • 393 citations

Nuclear Proto-Oncogenes Fos and Jun

1990 • 392 citations

Negative regulation of the rat stromelysin gene promoter by retinoic acid is mediated by an AP1 binding site.

1990 • 377 citations

A crucial role for neurotrophin-3 in oligodendrocyte development

1994 • 353 citations

Astrocytes, ependymal cells, and oligodendrocytes develop on schedule in dissociated cell cultures of embryonic rat brain

1981 • 351 citations

Purified astrocytes promote the in vitro division of a bipotential glial progenitor cell.

1984 • 336 citations

A quantitative immunohistochemical study of macroglial cell development in the rat optic nerve: In vivo evidence for two distinct astrocyte lineages

1985 • 316 citations

Relationship of c-erbA mRNA content to tissue triiodothyronine nuclear binding capacity and function in developing and adult rats.

1990 • 298 citations

Reconstitution of a developmental clock in vitro: a critical role for astrocytes in the timing of oligodendrocyte differentiation

1985 • 296 citations

Metamorphosis, a problem in developmental biology

1982 • 295 citations

Thyroid hormone receptors: multiple forms, multiple possibilities

1993 • 291 citations

Does oligodendrocyte survival depend on axons?

1993 • 291 citations

Replicative senescence of human fibroblast-like cells in culture

1993 • 270 citations

Two proliferative stages of the oligodendrocyte lineage (A2B5+O4- and O4+GaIC-) under different mitogenic control

1990 • 270 citations

Differentiation of a bipotential glial progenitor cell in single cell microculture

1985 • 262 citations

Differential and tissue-specific regulation of the multiple rat c-erbA messenger RNA species by thyroid hormone.

1990 • 257 citations

Identification of a Rat c-erbAα-Related Protein Which Binds Deoxyribonucleic Acid but does not Bind Thyroid Hormone

1988 • 254 citations

Proliferation and differentiation potential of rat forebrain oligodendroglial progenitors both in vitro and in vivo

1991 • 249 citations

Extended Culture of Mouse Embryo Cells Without Senescence: Inhibition by Serum

1987 • 220 citations

Nuclear thyroid hormone receptors.

1990 • 217 citations

Thyroid Hormone Regulation of Gene Expression

1994 • 206 citations

Transcription factor AP-1 activity is required for initiation of DNA synthesis and is lost during cellular aging.

1992 • 187 citations

Fos is a preferential target of glucocorticoid receptor inhibition of AP-1 activity in vitro.

1993 • 167 citations

Retinoic acid and development of the central nervous system

1992 • 162 citations

Retinoic acid receptors and retinoid X receptor-alpha down-regulate the transforming growth factor-beta 1 promoter by antagonizing AP-1 activity.

1993 • 160 citations

Novel Pathway for Thyroid Hormone Receptor Action through Interaction with jun and fos Oncogene Activities

1991 • 154 citations

Distinct functions for thyroid hormone receptors alpha and beta in brain development indicated by differential expression of receptor genes.

1991 • 149 citations

Detection of human white cell proliferative responses by immunoenzymatic measurement of bromodeoxyuridine uptake

1988 • 148 citations

Specific glucocorticoid-binding macromolecules from mouse fibroblasts growing in vitro. A possible steroid receptor for growth inhibition.

1970 • 131 citations

Effect of Thyroid Hormone on Growth and Development

1983 • 126 citations

Glial cells express both mineralocorticoid and glucocorticoid receptors

1991 • 120 citations

Effects of Altered Thyroid States on Myelinogenesis

1981 • 118 citations

Dominant negative activity of an endogenous thyroid hormone receptor variant (alpha 2) is due to competition for binding sites on target genes.

1993 • 118 citations

Differential regulation of oligodendrocyte markers by glucocorticoids: post-transcriptional regulation of both proteolipid protein and myelin basic protein and transcriptional regulation of glycerol phosphate dehydrogenase.

1989 • 109 citations

Triiodothyronine Stimulation of Oligodendroglial Differentiation and Myelination

1985 • 106 citations

A conserved C-terminal sequence that is deleted in v-ErbA is essential for the biological activities of c-ErbA (the thyroid hormone receptor).

1993 • 103 citations

Cellular and molecular mechanisms of aging

1993 • 102 citations

Triiodothyronine Has Diverse and Multiple Stimulating Effects on Expression of the Major Myelin Protein Genes

1992 • 97 citations

An immunocytochemical analysis of the ontogeny of the microtubule-associated proteins MAP-2 and Tau in the nervous system of the rat

1987 • 87 citations

Ultrastructural Aspects of Erythropoietic Differentiation in Long-term Bone Marrow Culture

1982 • 87 citations

Potentiation of human erythropoiesis in vitro by thyroid hormone

1978 • 85 citations

Retinoids increase perinatal spinal cord neuronal survival and astroglial differentiation

1990 • 85 citations

Immunocytochemical delineation of thyroid hormone receptor beta 2-like immunoreactivity in the rat central nervous system.

1993 • 84 citations

Thyroid receptors in the rat brain

1992 • 80 citations

An altered repertoire of (AP-1) at the onset of replicative senescence

1992 • 67 citations

Generation of chick skeletal muscle cells in groups of 16 from stem cells

1985 • 61 citations

Evidence for the Presence of Nuclear 3,5,3′- Triiodothyronine Receptors in Secondary Cultures of Pure Rat Oligodendrocytes*

1988 • 56 citations

Recovery of myelination in rat optic nerve after developmental retardation by cortisol

1982 • 52 citations

Thyroid function during postnatal development in the rat

1968 • 52 citations

Effects of triiodothyronine on the synthesis of sulfolipids by oligodendrocyte-enriched glial cultures

1986 • 52 citations

Effects of thyroxine on postnatal cell acquisition in the rat brain

1979 • 50 citations

Loss of transcription factor AP‐1 DNA binding activity during lymphocyte aging in vivo

1992 • 49 citations

Synthesis of retinoic acid from retinol by cultured rabbit Müller cells

1992 • 48 citations

Hydrocortisone stimulates the development of oligodendrocytes in primary glial cultures and affects glucose metabolism and lipid synthesis in these cultures

1987 • 46 citations

Chimeric retinoic acid/thyroid hormone receptors implicate RAR-alpha 1 as mediating growth inhibition by retinoic acid.

1993 • 43 citations

Mechanism of action of hydrocortisone potentiation of sulfogalactosylceramide synthesis in mouse oligodendroglioma clonal cell lines.

1979 • 38 citations

Early adrenalectomy increases myelin content of the rat brain

1985 • 38 citations

Dexamethasone Stimulates the Biochemical Differentiation of Fetal Forebrain Cells in Reaggregating Cultures

1986 • 33 citations

Adrenalectomy of Rats Results in Hypomyelination of the Central Nervous System

1984 • 32 citations

Transcription factor activity during cellular aging of human diploid fibroblasts

1992 • 30 citations

14. THE THYROID AS A TIME CLOCK IN THE DEVELOPING NERVOUS SYSTEM

1971 • 26 citations

Investigation of Myelinogenesis in Vitro: Transient Expression of 3,5,3’-Triiodothyronine Nuclear Receptors in Secondary Cultures of Pure Rat Oligodendrocytes

1989 • 17 citations

Structure and function of the glucocorticoid receptor

1987 • 14 citations

Regulation of arylsulphatase A and sulphogalactolipid turnover by cortisol in myelinogenic cultures of cells dissociated from embryonic mouse brain

1984 • 10 citations

Regulation of Thyroid Hormone Metabolism in the Brain

1989 • 2 citations