Human Brain Malformations and Their Lessons for Neuronal Migration

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1996 • 1,902 citations

A protein related to extracellular matrix proteins deleted in the mouse mutant reeler

1995 • 1,720 citations

Actin-Based Cell Motility and Cell Locomotion

1996 • 1,536 citations

Doublecortin Is a Microtubule-Associated Protein and Is Expressed Widely by Migrating Neurons

1999 • 1,297 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

Reeler/Disabled-like Disruption of Neuronal Migration in Knockout Mice Lacking the VLDL Receptor and ApoE Receptor 2

1999 • 1,231 citations

Slit Proteins Bind Robo Receptors and Have an Evolutionarily Conserved Role in Repulsive Axon Guidance

1999 • 1,155 citations

Isolation of a Miller–Dicker lissencephaly gene containing G protein β-subunit-like repeats

1993 • 1,067 citations

D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA

1992 • 1,023 citations

doublecortin, a Brain-Specific Gene Mutated in Human X-Linked Lissencephaly and Double Cortex Syndrome, Encodes a Putative Signaling Protein

1998 • 1,019 citations

Cyclin D1 provides a link between development and oncogenesis in the retina and breast

1995 • 1,017 citations

Slit Is the Midline Repellent for the Robo Receptor in Drosophila

1999 • 930 citations

Direct Binding of Reelin to VLDL Receptor and ApoE Receptor 2 Induces Tyrosine Phosphorylation of Disabled-1 and Modulates Tau Phosphorylation

1999 • 902 citations

Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations

2000 • 867 citations

Mutations in filamin 1 Prevent Migration of Cerebral Cortical Neurons in Human Periventricular Heterotopia

1998 • 858 citations

CENTRAL NERVOUS SYSTEM NEURONAL MIGRATION

1999 • 808 citations

Reelin Is a Ligand for Lipoprotein Receptors

1999 • 803 citations

An ancient retrotransposal insertion causes Fukuyama-type congenital muscular dystrophy

1998 • 797 citations

A Novel CNS Gene Required for Neuronal Migration and Involved in X-Linked Subcortical Laminar Heterotopia and Lissencephaly Syndrome

1998 • 740 citations

Mice Lacking p35, a Neuronal Specific Activator of Cdk5, Display Cortical Lamination Defects, Seizures, and Adult Lethality

1997 • 727 citations

Scrambler and yotari disrupt the disabled gene and produce a reeler -like phenotype in mice

1997 • 637 citations

The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation.

1996 • 592 citations

Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality

1998 • 571 citations

Reelin Binds α3β1 Integrin and Inhibits Neuronal Migration

2000 • 564 citations

Regulation of Area Identity in the Mammalian Neocortex by Emx2 and Pax6

2000 • 564 citations

A LIS1/NUDEL/Cytoplasmic Dynein Heavy Chain Complex in the Developing and Adult Nervous System

2000 • 506 citations

slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains.

1990 • 499 citations

NUDEL Is a Novel Cdk5 Substrate that Associates with LIS1 and Cytoplasmic Dynein

2000 • 482 citations

Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex.

1992 • 472 citations

Congenital progressive muscular dystrophy of the fukuyama type — clinical, genetic and pathological considerations —

1981 • 469 citations

Diagnostic criteria for Walker‐Warburg syndrome

1989 • 446 citations

Repulsive Axon Guidance

2000 • 434 citations

A role for the lissencephaly gene LIS1 in mitosis and cytoplasmic dynein function

2000 • 432 citations

Mena Is Required for Neurulation and Commissure Formation

1999 • 415 citations

The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity

1998 • 403 citations

Essential Roles for the Abl and Arg Tyrosine Kinases in Neurulation

1998 • 403 citations

A Classification Scheme for Malformations of Cortical Development

1996 • 389 citations

Cables Links Cdk5 and c-Abl and Facilitates Cdk5 Tyrosine Phosphorylation, Kinase Upregulation, and Neurite Outgrowth

2000 • 378 citations

Lissencephaly. A human brain malformation associated with deletion of the LIS1 gene located at chromosome 17p13

1993 • 376 citations

Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain

1998 • 370 citations

LIS1 and XLIS (DCX) mutations cause most classical lissencephaly, but different patterns of malformation

1998 • 352 citations

NudF, a nuclear migration gene in Aspergillus nidulans, is similar to the human LIS-1 gene required for neuronal migration.

1995 • 337 citations

Mouse disabled (mDab1): a Src binding protein implicated in neuronal development

1997 • 337 citations

Tokyo campus rising

1998 • 336 citations

Differential Origins of Neocortical Projection and Local Circuit Neurons: Role of Dlx Genes in Neocortical Interneuronogenesis

1999 • 328 citations

Lissencephaly and Other Malformations of Cortical Development: 1995 Update

1995 • 323 citations

An actin-binding function contributes to transformation by the Bcr-Abl oncoprotein of Philadelphia chromosome-positive human leukemias.

1993 • 317 citations

Cyclin-Dependent Kinase 5-Deficient Mice Demonstrate Novel Developmental Arrest in Cerebral Cortex

1998 • 315 citations

Point Mutations and an Intragenic Deletion in LIS1, the Lissencephaly Causative Gene in Isolated Lissencephaly Sequence and Miller-Dieker Syndrome

1997 • 314 citations

Periventricular Heterotopia: An X-Linked Dominant Epilepsy Locus Causing Aberrant Cerebral Cortical Development

1996 • 301 citations

Reduction of microtubule catastrophe events by LIS1, platelet-activating factor acetylhydrolase subunit

1997 • 298 citations

LIS1 Regulates CNS Lamination by Interacting with mNudE, a Central Component of the Centrosome

2000 • 296 citations

DLX-1, DLX-2, and DLX-5 expression define distinct stages of basal forebrain differentiation

1999 • 292 citations

Slit2-Mediated Chemorepulsion and Collapse of Developing Forebrain Axons

1999 • 280 citations

A mouse model for Zellweger syndrome

1997 • 271 citations

Aberrant Splicing of a Mouse disabled Homolog, mdab1, in the scrambler Mouse

1997 • 263 citations

Doublecortin, a Stabilizer of Microtubules

1999 • 263 citations

CNS Gene Encoding Astrotactin, Which Supports Neuronal Migration Along Glial Fibers

1996 • 256 citations

Area identity shifts in the early cerebral cortex of Emx2−/− mutant mice

2000 • 251 citations

The Reelin Receptor ApoER2 Recruits JNK-interacting Proteins-1 and -2

2000 • 245 citations

X-linked malformations of neuronal migration

1996 • 240 citations

Drosophila abl tyrosine kinase in embryonic CNS axons: A role in axonogenesis is revealed through dosage-sensitive interactions with disabled

1989 • 240 citations

Reelin mRNA Expression During Mouse Brain Development

1997 • 226 citations

Differences in the gyral pattern distinguish chromosome 17–linked and X-linked lissencephaly

1999 • 224 citations

Astrotactin provides a receptor system for CNS neuronal migration

1991 • 215 citations

Magnetic resonance imaging in childhood intractable partial epilepsies

1993 • 212 citations

Drosophila Lis1 is required for neuroblast proliferation, dendritic elaboration and axonal transport

2000 • 208 citations

Peroxisomal Disorders: Genotype, Phenotype, Major Neuropathologic Lesions, and Pathogenesis

1998 • 200 citations

Profilin and the Abl Tyrosine Kinase Are Required for Motor Axon Outgrowth in the Drosophila Embryo

1999 • 199 citations

Ligand-induced changes in integrin expression regulate neuronal adhesion and neurite outgrowth

1997 • 193 citations

Cerebellar histogenesis is disturbed in mice lacking cyclin D2

1999 • 192 citations

Astrotactin: a novel neuronal cell surface antigen that mediates neuron-astroglial interactions in cerebellar microcultures

1988 • 192 citations

X chromosome-linked Kallmann syndrome: stop mutations validate the candidate gene.

1992 • 189 citations

Reelin Regulates the Development and Synaptogenesis of the Layer-Specific Entorhino-Hippocampal Connections

1999 • 189 citations

Clinical and genetic distinction between Walker–Warburg syndrome and muscle–eye–brain disease

2001 • 184 citations

Focal Epileptogenesis in a Rat Model of Polymicrogyria

1999 • 178 citations

Brain acetylhydrolase that inactivates platelet-activating factor is a G-protein-like trimer

1997 • 175 citations

Folding of Proteins with WD-Repeats: Comparison of Six Members of the WD-Repeat Superfamily to the G Protein β Subunit

1996 • 175 citations

The Lis1-Related Nudf Protein of Aspergillus nidulans Interacts with the Coiled-Coil Domain of the Nude/Ro11 Protein

2000 • 171 citations

Syndromes of bilateral symmetrical polymicrogyria.

1999 • 169 citations

Primary Autosomal Recessive Microcephaly (MCPH1) Maps to Chromosome 8p22-pter

1998 • 167 citations

Characterization of mutations in the genedoublecortin in patients with double cortex syndrome

1999 • 166 citations

Muscle—eye—brain disease: A neuropathological study

1997 • 166 citations

Mutation analysis of the DCX gene and genotype/phenotype correlation in subcortical band heterotopia

2001 • 160 citations

Familial schizencephaly associated with EMX2 mutation

1997 • 159 citations

Familial perisylvian polymicrogyria: A new familial syndrome of cortical maldevelopment

2000 • 159 citations

A novel disruption of cortical development inp35?/? mice distinct fromreeler

1998 • 158 citations

Bilateral parasagittal parietooccipital polymicrogyria and epilepsy

1997 • 155 citations

Periventricular heterotopia and epilepsy

1994 • 155 citations

Targeted Deletion of the PEX2 Peroxisome Assembly Gene in Mice Provides a Model for Zellweger Syndrome, a Human Neuronal Migration Disorder

1997 • 152 citations

Patient Mutations in Doublecortin Define a Repeated Tubulin-binding Domain

2000 • 148 citations

Anosmin-1 is a regionally restricted component of basement membranes and interstitial matrices during organogenesis: Implications for the developmental anomalies of X chromosome-linked Kallmann syndrome

1999 • 146 citations

Slit Inhibition of Retinal Axon Growth and Its Role in Retinal Axon Pathfinding and Innervation Patterns in the Diencephalon

2000 • 146 citations

Subependymal heterotopia: a distinct neuronal migration disorder associated with epilepsy.

1994 • 142 citations

A Genetic Animal Model of Human Neocortical Heterotopia Associated with Seizures

1997 • 140 citations

Abnormal reorganization of preplate neurons and their associated extracellular matrix: An early manifestation of altered neocortical development in the reeler mutant mouse

1997 • 140 citations

Lissencephaly with Cerebellar Hypoplasia (LCH): A Heterogeneous Group of Cortical Malformations

2001 • 139 citations

Assignment of the Muscle-Eye-Brain Disease Gene to 1p32-p34 by Linkage Analysis and Homozygosity Mapping

1999 • 137 citations

The Lack ofEmx2Causes Impairment ofReelinSignaling and Defects of Neuronal Migration in the Developing Cerebral Cortex

2000 • 137 citations

X-linked lissencephaly with absent corpus callosum and ambiguous genitalia

1999 • 130 citations

Bilateral frontal polymicrogyria

2000 • 128 citations

Neuronal Heterotopias in the Developing Cerebral Cortex Produced by Neurotrophin-4

1997 • 125 citations

Structure of the X–linked Kallmann syndrome gene and its homologous pseudogene on the Y chromosome

1992 • 116 citations

The second locus for autosomal recessive primary microcephaly (MCPH2) maps to chromosome 19q13.1–13.2

1999 • 109 citations

Anosmin-1 underlying the X chromosome-linked Kallmann syndrome is an adhesion molecule that can modulate neurite growth in a cell-type specific manner

1998 • 108 citations

A Third Novel Locus for Primary Autosomal Recessive Microcephaly Maps to Chromosome 9q34

2000 • 106 citations

Platelet-Activating Factor Receptor Stimulation Disrupts Neuronal MigrationIn Vitro

1998 • 105 citations

A Fifth Locus for Primary Autosomal Recessive Microcephaly Maps to Chromosome 1q31

2000 • 103 citations

Dynamic Synapses in the Cortex

1997 • 101 citations

Microlissencephaly: A Heterogeneous Malformation of Cortical Development

1998 • 98 citations

The Fukuyama congenital muscular dystrophy story

2000 • 97 citations

Linkage and physical mapping of X-linked lissencephaly/SBH (XLIS): a gene causing neuronal migration defects in human brain

1997 • 96 citations

Imaging Physiologic Dysfunction of Individual Hippocampal Subregions in Humans and Genetically Modified Mice

2000 • 84 citations

Identification of a Duplication of Xq28 Associated with Bilateral Periventricular Nodular Heterotopia

1997 • 83 citations

Brain MR in Fukuyama congenital muscular dystrophy.

1996 • 78 citations

Callosal axon guidance defects in p35?/? mice

1999 • 76 citations

A Number of Schizencephaly Patients Including 2 Brothers Are Heterozygous for Germline Mutations in the Homeobox Gene EMX2

1997 • 75 citations

Bilateral periventricular nodular heterotopia with mental retardation and frontonasal malformation

1998 • 72 citations

Deletion of nudC, a nuclear migration gene of Aspergillus nidulans, causes morphological and cell wall abnormalities and is lethal.

1997 • 65 citations

A number of schizencephaly patients including 2 brothers are heterozygous for germline mutations in the homeobox gene EMX2.

1997 • 63 citations

Bilateral perisylvian polymicrogyria in three generations

1999 • 61 citations

Neurogenetics of the Cerebellar System

1999 • 60 citations

LIS1 is a microtubule‐associated phosphoprotein

1999 • 59 citations

On the molecular etiology of decreased arachidonic (20:4n-6), docosapentaenoic (22:5n-6) and docosahexaenoic (22:6n-3) acids in Zellweger syndrome and other peroxisomal disorders.

1997 • 59 citations

Agenesis of Corpus Callosum: Clinical Description and Etiology

2000 • 57 citations

Development of Commissural Connections in the Hippocampus of Reeler Mice: Evidence of an Inhibitory Influence of Cajal–Retzius Cells

1999 • 52 citations

Familial periventricular nodular heterotopia

1993 • 50 citations

Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development

2000 • 50 citations

A Sibship with a Neuronal Migration Defect, Cerebellar Hypoplasia and Congenital Lymphedema

1993 • 47 citations

Distinct roles of profilin in cell morphological changes: microspikes, membrane ruffles, stress fibers, and cytokinesis

1999 • 46 citations

Heterotopic Neurogenesis in a Rat with Cortical Heterotopia

1998 • 44 citations

Cobblestone Lissencephaly with Normal Eyes and Muscle

1996 • 42 citations

Ocular findings in Walker-Warburg syndrome

1993 • 35 citations

Novel Missense Mutation in the L1 Gene in a Child With Corpus Callosum Agenesis, Retardation, Adducted Thumbs, Spastic Paraparesis, and Hydrocephalus

2000 • 31 citations

Developmental aspects of type II lissencephaly

1995 • 29 citations

Microcephaly with simplified gyral pattern in six related children

1999 • 28 citations

Bilateral frontoparietal polymicrogyria and epilepsy

2000 • 27 citations

Microlissencephaly

1998 • 26 citations

Muscle-eye-brain disease and Fukuyama type congenital muscular dystrophy are not allelic

1995 • 26 citations

Autosomal Recessive Micrencephaly with Simplified Gyral Pattern, Abnormal Myelination and Arthrogryposis

1999 • 25 citations

Fine structure physical mapping of a 1·9 Mb region of chromosome 13q12

1997 • 24 citations

Familial perisylvian polymicrogyria: A new familial syndrome of cortical maldevelopment

2000 • 22 citations

Diffuse pachygyria with cerebellar hypoplasia: A milder form of microlissencephaly or a new genetic syndrome?

1999 • 21 citations

Fukuyama congenital muscular dystrophy

2001 • 17 citations

Non-progressive familial congenital cerebellar hypoplasia

1995 • 13 citations

Spatial and temporal development of the gliovascular tissue in type II lissencephaly

1997 • 9 citations

Walker–Warburg syndrome is genetically distinct from Fukuyama type congenital muscular dystrophy

2000 • 8 citations

X‐linked lissencephaly with absent corpus callosum and ambiguous genitalia

1999 • 8 citations

Growth Factor Influences on the Production and Migration of Cortical Neurons

2000 • 5 citations

Fine structure physical mapping of a 1·9 Mb region of chromosome 13q12

1997 • 3 citations

[Neuropathology of peroxisomal disorders; Zellweger syndrome and neonatal adrenoleukodystrophy].

1992 • 3 citations

Developmental aspects of type II lissencephaly

1994 • 1 citations