Cytokines and Peripheral Tolerance to Alloantigen

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

‘Actively Acquired Tolerance’ of Foreign Cells

1953 • 3,103 citations

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

CTLA-4 is a second receptor for the B cell activation antigen B7.

1991 • 1,662 citations

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

1991 • 1,479 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

1987 • 1,166 citations

Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg

1992 • 1,156 citations

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

1991 • 1,054 citations

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.

1990 • 954 citations

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

1989 • 910 citations

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

1990 • 904 citations

HYPERACUTE REJECTION OF KIDNEY ALLOGRAFTS, ASSOCIATED WITH PRE-EXISTING HUMORAL ANTIBODIES AGAINST DONOR CELLS

1966 • 897 citations

Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones.

1988 • 845 citations

Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni.

1991 • 777 citations

The role of IL-10 in crossregulation of TH1 and TH2 responses

1991 • 775 citations

Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system.

1992 • 762 citations

T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1.

1990 • 745 citations

Role of the CD28 receptor in T-cell activation

1990 • 684 citations

CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines.

1989 • 662 citations

Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28

1991 • 660 citations

Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism.

1990 • 629 citations

T Cell Control of Antibody Production

1974 • 582 citations

T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo.

1992 • 558 citations

T-Cell Proliferation Involving the CD28 Pathway Is Associated witH Cyclosporine-Resistant Interleukin 2 Gene Expression

1987 • 522 citations

Clonal anergy induced in mature Vβ6+ T lymphocytes on immunizing Mls-1b mice with Mls-1a expressing cells

1989 • 462 citations

Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin.

1983 • 441 citations

CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location.

1991 • 422 citations

T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression.

1987 • 354 citations

Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells

1988 • 343 citations

Selective induction of B7/BB-1 on interferon-γ stimulated monocytes: A potential mechanism for amplification of T cell activation through the CD28 pathway

1991 • 325 citations

Induction of classical transplantation tolerance in the adult.

1989 • 325 citations

Identification and distribution of the costimulatory receptor CD28 in the mouse.

1992 • 316 citations

Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones.

1987 • 310 citations

Functional expression of the costimulatory molecule, B7/BB1, on murine dendritic cell populations.

1992 • 306 citations

HEART ALLOGRAFTS IN MURINE SYSTEMS

1992 • 299 citations

Peripheral tolerance to alloantigen results from altered regulation of the interleukin 2 pathway.

1991 • 298 citations

Cytokine gene transcription in vascularised organ grafts: analysis using semiquantitative polymerase chain reaction.

1991 • 267 citations

Diabetes in transgenic mice resulting from over-expression of class I histocompatibility molecules in pancreatic β cells

1988 • 266 citations

Transforming growth factor-beta and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype.

1991 • 254 citations

Tolerance of class I histocompatibility antigens expressed extrathymically

1989 • 251 citations

Autoimmune diabetes as a consequence of locally produced interleukin-2

1992 • 242 citations

T-cell tolerance by clonal anergy in transgenic mice with nonlymphoid expression of MHC class II I–E

1989 • 238 citations

The Relationship Between Humoral and Cell‐Mediated Immunity

1972 • 228 citations

Multiple levels of peripheral tolerance

1993 • 216 citations

Phenotype, specificity, and function of T cell subsets and T cell interactions involved in skin allograft rejection.

1987 • 198 citations

Administration of an anti-interleukin 2 receptor monoclonal antibody prolongs cardiac allograft survival in mice.

1985 • 194 citations

Kidney Transplantation: Principles and Practice

1988 • 154 citations

CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production.

1992 • 153 citations

Interleukin-2 can prevent and reverse antigen-induced unresponsiveness in cloned human T lymphocytes.

1988 • 146 citations

The murine homologue of the T lymphocyte antigen CD28. Molecular cloning and cell surface expression.

1990 • 141 citations

Distinct mechanisms of extrathymic T cell tolerance due to differential expression of self antigen

1992 • 128 citations

PERIPHERAL TOLERANCE OF AN ALLOGRAFT IN ADULT RATS—CHARACTERIZATION BY LOW INTERLEUKIN-2 AND INTERFERON-γ mRNA LEVELS AND BY STRONG ACCUMULATION OF MAJOR HISTOCOMPATIBILITY COMPLEX TRANSCRIPTS IN THE GRAFT

1992 • 117 citations

Analysis of T-cell subsets in rejection of Kb mutant skin allografts differing at class I MHC

1986 • 114 citations

Rapamycin: FK506's fraternal twin or distant cousin?

1991 • 107 citations

INTERLEUKIN 2 RECEPTOR-TARGETED THERAPY—RATIONALE AND APPLICATIONS IN ORGAN TRANSPLANTATION

1988 • 98 citations

In vivo effects of anti-IL-4 monoclonal antibody on neonatal induction of tolerance and on an associated autoimmune syndrome.

1990 • 93 citations

Patterns of cytokine secretion in murine leishmaniasis: correlation with disease progression or resolution

1990 • 86 citations

T cell requirements for the rejection of renal allografts bearing an isolated class I MHC disparity.

1990 • 80 citations

Resistance to murine cutaneous leishmaniasis is mediated by T_H1 cells, but disease‐promoting CD4⁺ cells are different from T_H2 cells

1990 • 69 citations

Regulation and development of cytochrome c-specific IL-4-producing T cells.

1990 • 63 citations

CD28 mRNA rapidly decays when activated T cells are functionally anergized with specific peptide

1993 • 51 citations

Human neural graft function in rats treated with anti-interleukin II receptor antibody

1990 • 43 citations

T-cell regulation of T-cell responses to antigen.

1974 • 39 citations

Cd28 and Ctla-4, two related members of the Ig supergene family, are tightly linked on proximal mouse chromosome 1

1991 • 39 citations

Specific tolerance to neural allografts induced with an antibody to the interleukin 2 receptor.

1993 • 37 citations

Polyclonal B cell activation by a B cell differentiation factor, B151-TRF2. III. B151-TRF2 as a B cell differentiation factor closely associated with autoimmune disease.

1987 • 35 citations

A monoclonal antibody to the interleukin-2 receptor enhances the survival of neural allografts: A time-course study

1992 • 30 citations

Selective immunosuppression with anti‐interleukin 2 receptor‐targeted therapy: helper and suppressor cell activity in rat recipients of cardiac allografts

1987 • 30 citations

Increased expression of Ia antigens on B cells after neonatal induction of lymphoid chimerism in mice: Role of interleukin 4

1990 • 27 citations

Identification of a cDNA encoding the rat CD28 homologue

1992 • 17 citations

DIFFERENTIAL EXPRESSION OF HELPER VERSUS EFFECTOR ACTIVITY IN MICE RENDERED NEONATALLY TOLERANT OF CLASS II MHC ANTIGENS

1989 • 13 citations

REJECTION OF PRIMARILY VASCULARIZED HEART GRAFTS

1990 • 7 citations

Treatment with rIFN-gamma has no effect on cardiac allograft rejection.

1991 • 6 citations

Effects of gamma interferon and interleukin-2, and of gamma-interferon antibodies, on the rat immune response against allografts.

1989 • 6 citations