Resistance to murine cutaneous leishmaniasis is mediated by T_H1 cells, but disease‐promoting CD4⁺ cells are different from T_H2 cells

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.

1989 • 1,462 citations

Monoclonal Antibodies: Principles and Practice

1996 • 928 citations

Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo

1984 • 884 citations

An improved colorimetric assay for interleukin 2

1986 • 858 citations

Human naive and memory T cells

1988 • 793 citations

Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1

1985 • 749 citations

Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens.

1988 • 713 citations

Monoclonal Antibodies: Principles and Practice

1985 • 648 citations

Continuous proliferation of murine antigen-specific helper T lymphocytes in culture.

1979 • 522 citations

Monoclonal antibody to murine gamma interferon inhibits lymphokine-induced antiviral and macrophage tumoricidal activities.

1984 • 386 citations

A new murine CD4+ T cell subset with an unrestricted cytokine profile.

1989 • 374 citations

Effective immunization against cutaneous leishmaniasis with defined membrane antigens reconstituted into liposomes.

1988 • 236 citations

IL-4 inhibits H2O2 production and antileishmanial capacity of human cultured monocytes mediated by IFN-gamma.

1989 • 228 citations

Therapeutic effect of anti-L3T4 monoclonal antibody GK1.5 on cutaneous leishmaniasis in genetically-susceptible BALB/c mice.

1985 • 225 citations

Vaccination against cutaneous leishmaniasis in a murine model. I. Induction of protective immunity with a soluble extract of promastigotes.

1987 • 212 citations

Immunological regulation of experimental cutaneous leishmaniasis. IV. Prophylactic effect of sublethal irradiation as a result of abrogation of suppressor T cell generation in mice genetically susceptible to leishmania tropica

1981 • 199 citations

Tumor necrosis factor‐α in combination with interferon‐γ, but not with interleukin 4 activates murine macrophages for elimination of Leishmania major amastigotes

1990 • 179 citations

Thymocyte subpopulations: an experimental review, including flow cytometric cross-correlations between the major murine thymocyte markers.

1983 • 178 citations

Murine cutaneous leishmaniasis: resistance correlates with the capacity to generate interferon-gamma in response to Leishmania antigens in vitro.

1986 • 169 citations

Frequencies of IL-2- and IL-4-secreting T cells in naive and antigen-stimulated lymphocyte populations.

1988 • 164 citations

Immunologic regulation of experimental cutaneous leishmaniasis. V. Characterization of effector and specific suppressor T cells.

1982 • 163 citations

Cell Separation: Methods and Selected Applications

1983 • 158 citations

Production of Interferon-Gamma during Infection of Mice with Plasmodium chabaudi chabaudi

1989 • 157 citations

Cutaneous leishmaniasis in anti-IgM-treated mice: enhanced resistance due to functional depletion of a B cell-dependent T cell involved in the suppressor pathway.

1984 • 153 citations

Monoclonal antibodies against murine gamma interferon.

1984 • 153 citations

Regulation of activated macrophage antimicrobial activities. Identification of lymphokines that cooperate with IFN-gamma for induction of resistance to infection.

1988 • 150 citations

Immunization with Leishmania receptor for macrophages protects mice against cutaneous leishmaniasis.

1985 • 145 citations

Suppressive effect of cyclosporin A on the development of Leishmania tropica-induced lesions in genetically susceptible BALB/c mice.

1986 • 138 citations

CUTANEOUS LEISHMANIASIS IN MICE: DISEASE PATTERNS IN RECONSTITUTED NUDE MICE OF SEVERAL GENOTYPES INFECTED WITH LEISHMANIA TROPICA

1980 • 82 citations

Intracellular destruction of Leishmania tropica by macrophages activated with macrophage activating factor/interferon.

1984 • 78 citations

The induction of protective immunity to Leishmania major in the BALB/c mouse by interleukin 4 treatment

1989 • 65 citations

Evidence of T-cell recognition in mice of a purified lipophosphoglycan from Leishmania major

1989 • 57 citations

Immunity to experimental infection with Leishmania major: generation of protective L3T4⁺ T cell clones recognizing antigen(s) associated with live parasites

1989 • 56 citations

Limiting Dilution Assays for the Separation, Characterization, and Quantitation of Biologically Active Particles and Their Clonal Progeny

1987 • 54 citations

Resistance to cutaneous leishmaniasis in nude mice injected with L3T4⁺ T cells but not with Ly‐2⁺ T cells

1988 • 49 citations

Suppression of interleukin-2 production by macrophages in genetically susceptible mice infected with Leishmania major

1986 • 49 citations

In vitro and in vivo effects of interleukin 2 on the protozoan parasite leishmania

1989 • 43 citations

Effect of T-lymphocyte suppression on the parasite burden in Leishmania major-infected, genetically susceptible BALB/c mice

1986 • 42 citations

Production of tumour necrosis factor during murine cutaneous leishmaniasis

1990 • 27 citations

Kinetics of cell-mediated immunity developing during the course of Leishmania major infection in 'healer' and 'non-healer' mice: progressive impairment of response to and generation of interleukin-2.

1987 • 25 citations

Clonal Expansion and Differentiation to Effector Function in Normal CD4 T Cell Subpopulations

1989 • 3 citations

L3T4 T cells promoting susceptibility to murine cutaneous leishmaniasis express the surface marker Ly‐24 (Pgp‐1)

1989 • 3 citations