Proteins with transcription regulatory properties encoded by human adenoviruses

The p53 tumour suppressor gene

1991 • 3,871 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

The regulation of transcription by phosphorylation

1992 • 1,316 citations

Mechanism of transcriptional activation by Sp1: Evidence for coactivators

1990 • 1,029 citations

Transcriptional repression by YY1, a human GLI-Krüippel-related protein, and relief of repression by adenovirus E1A protein

1991 • 1,023 citations

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

1993 • 875 citations

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

1992 • 846 citations

Isolation of coactivators associated with the TATA-binding protein that mediate transcriptional activation

1991 • 711 citations

Retinoblastoma protein switches the E2F site from positive to negative element

1992 • 663 citations

Direct and selective binding of an acidic transcriptional activation domain to the TATA-box factor TFIID

1990 • 620 citations

Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein

1992 • 567 citations

Mechanism of action of an acidic transcriptional activator in vitro

1991 • 557 citations

The complexities of eukaryotic transcription initiation: regulation of preinitiation complex assembly

1991 • 497 citations

ADENOVIRUS PROMOTERS AND E1A TRANSACTIVATION

1986 • 460 citations

Adenovirus E1a prevents the retinoblastoma gene product from complexing with a cellular transcription factor

1991 • 435 citations

A specific member of the ATF transcription factor family can mediate transcription activation by the adenovirus E1a protein

1990 • 391 citations

Adenovirus E1A activation domain binds the basic repeat in the TATA box transcription factor

1991 • 381 citations

Dr1, a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription

1992 • 379 citations

Holo-TFIID supports transcriptional stimulation by diverse activators and from a TATA-less promoter.

1992 • 372 citations

Regulation of the Human hsp70 Promoter by p53

1993 • 297 citations

Analysis of E1A-mediated growth regulation functions: binding of the 300-kilodalton cellular product correlates with E1A enhancer repression function and DNA synthesis-inducing activity

1990 • 251 citations

E1a regions of the human adenoviruses and of the highly oncogenic simian adenovirus 7 are closely related

1985 • 213 citations

Domains required for in vitro association between the cellular p53 and the adenovirus 2 E1B 55k proteins

1990 • 207 citations

Activation of transcription factor IIIC by the adenovirus E1A protein

1988 • 197 citations

A nexus between Oct-4 and E1 A: Implications for gene regulation in embryonic stem cells

1991 • 188 citations

Domains of the adenovirus E1A protein required for oncogenic activity are also required for dissociation of E2F transcription factor complexes.

1991 • 161 citations

Mutations in the gene encoding the adenovirus early region 1B 19,000-molecular-weight tumor antigen cause the degradation of chromosomal DNA

1984 • 156 citations

Sequences in E1A proteins of human adenovirus 5 required for cell transformation, repression of a transcriptional enhancer, and induction of proliferating cell nuclear antigen

1989 • 150 citations

Adenovirus E1A targets key regulators of cell proliferation.

1992 • 148 citations

The adenovirus early region 4 open reading frame 6/7 protein regulates the DNA binding activity of the cellular transcription factor, E2F, through a direct complex.

1989 • 148 citations

Possible role of the 72,000 dalton DNA-binding protein in regulation of adenovirus type 5 early gene expression

1978 • 124 citations

p300, and p300-associated proteins, are components of TATA-binding protein (TBP) complexes.

1993 • 120 citations

Adenovirus E4orf4 protein reduces phosphorylation of c-Fos and E1A proteins while simultaneously reducing the level of AP-1

1992 • 107 citations

DNA-binding activity of the adenovirus-induced E4F transcription factor is regulated by phosphorylation.

1989 • 104 citations

Transcriptional Activation by the Adenovirus Larger E1a Product is Mediated by Members of the Cellular Transcription Factor ATF Family Which Can Directly Associate with E1a

1993 • 99 citations

Expression and interactions of human adenovirus oncoproteins

1991 • 88 citations

DNA-binding properties of the E1A-associated 300-kilodalton protein.

1992 • 87 citations

DNA-binding properties of an adenovirus 289R E1A protein.

1988 • 77 citations

Promoter-specific trans-activation by the adenovirus E1A12S product involves separate E1A domains.

1992 • 73 citations

Inhibition of adenovirus early region IV transcription in vitro by a purified viral DNA binding protein

1983 • 69 citations

Factors responsible for the higher transcriptional activity of extracts of adenovirus-infected cells fractionate with the TATA box transcription factor.

1988 • 60 citations

The hsp70 gene CCAAT-binding factor mediates transcriptional activation by the adenovirus E1a protein.

1992 • 46 citations

Transcriptional activation by the adenovirus larger E1a product is mediated by members of the cellular transcription factor ATF family which can directly associate with E1a.

1993 • 46 citations

Transactivation of host and viral genes by the adenovirus E1B 19K tumor antigen.

1987 • 45 citations

The adenovirus E1B 19-kilodalton protein stimulates gene expression by increasing DNA levels.

1989 • 44 citations

Negative regulation of the major histocompatibility complex class I enhancer in adenovirus type 12-transformed cells via a retinoic acid response element

1992 • 43 citations

E4F and ATF, two transcription factors that recognize the same site, can be distinguished both physically and functionally: a role for E4F in E1A trans activation.

1990 • 41 citations

Interactions between adenovirus E1A and members of the AP-1 family of cellular transcription factors.

1991 • 33 citations

The adenovirus E1A 12S product displays functional redundancy in activating the human proliferating cell nuclear antigen promoter

1993 • 32 citations

Isolation and characterization of insertion mutants in E1A of adenovirus type 5

1991 • 30 citations

Identification of a 60-kilodalton Rb-binding protein, RBP60, that allows the Rb-E2F complex to bind DNA.

1992 • 29 citations

The carboxy-terminal exon of the adenovirus E1A protein is required for E4F-dependent transcription activation.

1992 • 28 citations

Identification of a 60-Kilodalton Rb-Binding Protein, RBP60, That Allows the Rb-E2F Complex To Bind DNA

1992 • 27 citations

E1A-Mediated Activation of the Adenovirus E4 Promoter Can Occur Independently of the Cellular Transcription Factor E4F

1991 • 22 citations

Tandemly repeated hexamer sequences within the beta interferon promoter can function as an inducible regulatory element in activation by the adenovirus E1B 19-kilodalton protein

1990 • 16 citations

Repression of RNA polymerase III transcription by adenovirus E1A

1993 • 15 citations

E1A-mediated activation of the adenovirus E4 promoter can occur independently of the cellular transcription factor E4F.

1991 • 11 citations