SALMONELLOSIS: Host Immune Responses and Bacterial Virulence Determinants¹

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Genistein, a specific inhibitor of tyrosine-specific protein kinases.

1987 • 3,773 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.

1993 • 2,410 citations

Principles and Practice of Infectious Diseases

1986 • 1,542 citations

Protein phosphorylation and regulation of adaptive responses in bacteria

1989 • 1,495 citations

Simultaneous Identification of Bacterial Virulence Genes by Negative Selection

1995 • 1,202 citations

Mutants of Salmonella typhimurium that cannot survive within the macrophage are avirulent.

1986 • 1,116 citations

Natural resistance to infection with intracellular parasites: Isolation of a candidate for Bcg

1993 • 1,107 citations

Parallel signal processing among mammalian MAPKs

1995 • 1,015 citations

MAP kinase pathways in yeast: For mating and more

1995 • 1,009 citations

Cloning and molecular characterization of genes whose products allow Salmonella typhimurium to penetrate tissue culture cells.

1989 • 988 citations

A two-component regulatory system (phoP phoQ) controls Salmonella typhimurium virulence.

1989 • 943 citations

Salmonella typhimurium initiates murine infection by penetrating and destroying the specialized epithelial M cells of the Peyer's patches.

1994 • 859 citations

Actions of cytochalasins on the organization of actin filaments and microtubules in a neuronal growth cone.

1988 • 851 citations

Epithelial Cell Specialization within Human Peyer's Patches: An Ultrastructural Study of Intestinal Lymphoid Follicles

1974 • 757 citations

THE ROUTE OF ENTERIC INFECTION IN NORMAL MICE

1974 • 661 citations

Target cell contact triggers expression and polarized transfer of Yersinia YopE cytotoxin into mammalian cells.

1994 • 594 citations

Molecular and functional characterization of the Salmonella invasion gene invA: homology of InvA to members of a new protein family

1992 • 578 citations

Typhoid Fever: Pathogenesis and Immunologic Control

1970 • 570 citations

Pinocytosis by epithelium associated with lymphoid follicles in the bursa of fabricius, appendix, and Peyer's patches. An electron microscopic study

1973 • 562 citations

A large family of bacterial activator proteins.

1988 • 559 citations

Adaptive acidification tolerance response of Salmonella typhimurium

1990 • 543 citations

Electron microscope studies of experimental Salmonella infection. I. Penetration into the intestinal epithelium by Salmonella typhimurium.

1967 • 532 citations

The alternative sigma factor katF (rpoS) regulates Salmonella virulence.

1992 • 525 citations

Intestinal M Cells: A Pathway for Entry of Reovirus into the Host

1981 • 481 citations

Diversity in function and regulation of MAP kinase pathways

1994 • 469 citations

The ability of Salmonella to enter mammalian cells is affected by bacterial growth state.

1990 • 467 citations

Ruffles induced by Salmonella and other stimuli direct macropinocytosis of bacteria

1993 • 443 citations

Salmonella typhimurium activates virulence gene transcription within acidified macrophage phagosomes.

1992 • 441 citations

Specific immunity to listeria monocytogenes in the absence of IFNγ

1995 • 432 citations

Induction of Salmonella Stress Proteins Upon Infection of Macrophages

1990 • 429 citations

Summary of an International Workshop on Typhoid Fever

1986 • 406 citations

Constitutive expression of the phoP regulon attenuates Salmonella virulence and survival within macrophages

1990 • 399 citations

Prevention of Typhoid Fever in Nepal with the VI Capsular Polysaccharide ofSalmonella Typhi

1987 • 385 citations

Plasmid-associated virulence of Salmonella typhimurium

1987 • 376 citations

A 40 kb chromosomal fragment encoding Salmonella typhimurium invasion genes is absent from the corresponding region of the Escherichia coli K‐12 chromosome

1995 • 365 citations

M Cell Transport of Vibrio cholerae from the Intestinal. Lumen into Peyer's Patches: A Mechanism for Antigen Sampling and for Microbial Transepithelial Migration

1986 • 349 citations

Salmonella stimulate macrophage macropinocytosis and persist within spacious phagosomes.

1994 • 349 citations

Cytoskeletal rearrangements accompanying Salmonella entry into epithelial cells

1991 • 349 citations

Salmonella typhimurium phoP virulence gene is a transcriptional regulator.

1989 • 338 citations

Vaccines and cell-mediated immunity

1974 • 336 citations

Inducible pH homeostasis and the acid tolerance response of Salmonella typhimurium

1991 • 335 citations

Salmonella Interactions with Polarized Human Intestinal Caco-2 Epithelial Cells

1990 • 325 citations

Reduction of Mortality in Chloramphenicol-Treated Severe Typhoid Fever by High-Dose Dexamethasone

1984 • 317 citations

The Salmonella typhimurium invasion genes invF and invG encode homologues of the AraC and PulD family of proteins

1994 • 311 citations

The Interaction of Bacteria with Mammalian Cells

1992 • 304 citations

Identification of a Salmonella typhimurium invasion locus by selection for hyperinvasive mutants.

1992 • 297 citations

Expression of Salmonella typhimurium genes required for invasion is regulated by changes in DNA supercoiling

1990 • 296 citations

PROKARYOTIC SIGNAL TRANSDUCTION MEDIATED BY SENSOR AND REGULATOR PROTEIN PAIRS

1989 • 295 citations

Role of gamma interferon and tumor necrosis factor alpha in resistance to Salmonella typhimurium infection

1992 • 286 citations

A PhoP-repressed gene promotes Salmonella typhimurium invasion of epithelial cells

1993 • 281 citations

Comparison of the invasion strategies used by Salmonella cholerae-suis, Shigella flexneri and Yersinia enterocolitica to enter cultured animal cells: endosome acidification is not required for bacterial invasion or intracellular replication

1988 • 278 citations

Inhibition of macrophage phagosome-lysosome fusion by Salmonella typhimurium

1991 • 271 citations

Cognate gene clusters govern invasion of host epithelial cells by Salmonella typhimurium and Shigella flexneri.

1993 • 269 citations

Contact with epithelial cells induces the formation of surface appendages on Salmonella typhimurium

1994 • 264 citations

Intracellular replication is essential for the virulence of Salmonella typhimurium.

1991 • 264 citations

Resistance to host antimicrobial peptides is necessary for Salmonella virulence.

1992 • 260 citations

Signal transduction and invasion of epithelial cells by S. typhimurium

1993 • 260 citations

Targeting of Salmonella typhimurium to vesicles containing lysosomal membrane glycoproteins bypasses compartments with mannose 6-phosphate receptors.

1995 • 256 citations

Transport of membrane-bound macromolecules by M cells in follicle-associated epithelium of rabbit Peyer's patch

1987 • 253 citations

Salmonella typhimurium loci involved in survival within macrophages

1994 • 247 citations

Defensins

1990 • 241 citations

Preferential interaction of Salmonella typhimurium with mouse Peyer's patch M cells

1994 • 232 citations

Involvement of the epidermal growth factor receptor in the invasion of cultured mammalian cells by Salmonella typhimurium

1992 • 224 citations

Uptake and translocation of fluorescent latex particles by rabbit Peyer's patch follicle epithelium: a quantitative model for M cell uptake.

1989 • 222 citations

Molecular genetic analysis of a locus required for resistance to antimicrobial peptides in Salmonella typhimurium.

1993 • 221 citations

Cytopathogenic Effect of Salmonella typhi GIFU 10007 on M cells of Murine Ileal Peyer's Patches in Ligated Ileal Loops: An Ultrastructural Study

1986 • 219 citations

Adoptive transfer of immunity to oral challenge with virulent salmonellae in innately susceptible BALB/c mice requires both immune serum and T cells

1993 • 218 citations

Cryptosporidium: Cellular Localization, Structural Analysis of Absorptive CellParasite Membrane-Membrane Interactions in Guinea Pigs, and Suggestion of Protozoan Transport by M Cells

1986 • 218 citations

Anaerobiosis, type 1 fimbriae, and growth phase are factors that affect invasion of HEp-2 cells by Salmonella typhimurium

1990 • 217 citations

Morphological and cytoskeletal changes in epithelial cells occur immediately upon interaction with Salmonella typhimurium grown under low‐oxygen conditions

1992 • 214 citations

Virulence and vaccine potential of phoP mutants of Salmonella typhimurium

1989 • 211 citations

The hrp gene locus of Pseudomonas solanacearum, which controls the production of a type III secretion system, encodes eight proteins related to components of the bacterial flagellar biogenesis complex

1995 • 207 citations

Identification and molecular characterization of a Salmonella typhimurium gene involved in triggering the internalization of salmonellae into cultured epithelial cells.

1992 • 197 citations

The Salmonella typhimurium virulence plasmid increases the growth rate of salmonellae in mice

1993 • 191 citations

Tyrosine protein kinase inhibitors block invasin-promoted bacterial uptake by epithelial cells

1992 • 188 citations

Invasion of HeLa Cells by Salmonella typhimurium: A Model for Study of Invasiveness of Salmonella

1973 • 186 citations

Progress in Vaccines Against Typhoid Fever

1989 • 182 citations

Typhoid Fever: Pathogenesis and Immunologic Control

1970 • 181 citations

Recombination‐deficient mutants of Salmonella typhimurium are avirulent and sensitive to the oxidative burst of macrophages

1993 • 180 citations

Identification and characterization of a Salmonella typhimurium oxygen-regulated gene required for bacterial internalization

1994 • 173 citations

Immunosuppression induced by nitric oxide and its inhibition by interleukin‐4

1992 • 172 citations

Rearrangements in the genome of the bacterium Salmonella typhi.

1995 • 167 citations

Locating salmonella resistance gene on mouse chromosome 1.

1979 • 166 citations

Intestinal Colonization and Virulence of Salmonella in Mice

1978 • 163 citations

Bacterial resistance to complement killing mediated by the Ail protein of Yersinia enterocolitica.

1992 • 162 citations

Identification and antigenic characterization of virulence-associated, plasmid-coded proteins of Shigella spp. and enteroinvasive Escherichia coli

1985 • 161 citations

A Salmonella typhimurium virulence protein is similar to a Yersinia enterocolitica invasion protein and a bacteriophage lambda outer membrane protein

1991 • 160 citations

Virulence plasmids of Salmonella typhimurium and other salmonellae

1990 • 143 citations

Regulation of nonspecific acid phosphatase in Salmonella: phoN and phoP genes

1979 • 141 citations

Are the Lsh and Ity disease resistance genes at one locus on mouse chromosome 1?

1982 • 140 citations

The Invasion of HeLa Cells by Salmonella typhimurium: Reversible and Irreversible Bacterial Attachment and the Role of Bacterial Motility

1981 • 135 citations

Functional analysis of the Salmonella typhimurium invasion genes invl and invJ and identification of a target of the protein secretion apparatus encoded in the inv locus

1995 • 135 citations

The ail gene of Yersinia enterocolitica has a role in the ability of the organism to survive serum killing

1993 • 134 citations

Phagocytosis of Giardia muris by macrophages in Peyer's patch epithelium in mice

1981 • 122 citations

The role of IFN-γ in murine Salmonella typhimurium infection

1990 • 122 citations

Astrovirus and Breda virus infections of dome cell epithelium of bovine ileum

1984 • 121 citations

Salmonella typhimurium induces membrane ruffling by a growth factor-receptor-independent mechanism.

1993 • 120 citations

Protective effect of recombinant tumor necrosis factor-alpha in murine salmonellosis.

1990 • 115 citations

Growth rate paradox of Salmonella typhimurium within host macrophages

1993 • 113 citations

Host restriction phenotypes of Salmonella typhi and Salmonella gallinarum

1995 • 111 citations

Typhoid Fever Complicated by Intestinal Perforation: A Persisting Fatal Disease Requiring Surgical Management

1985 • 110 citations

Cloning and molecular characterization of a gene involved in Salmonella adherence and invasion of cultured epithelial cells

1993 • 106 citations

Role of acid tolerance response genes in Salmonella typhimurium virulence

1993 • 106 citations

Growth regulation of a Salmonella plasmid gene essential for virulence

1991 • 100 citations

Induction of gamma/delta T cells in murine salmonellosis by an avirulent but not by a virulent strain of Salmonella choleraesuis.

1992 • 98 citations

Functional morphology of microfold cells (M cells) in Peyer's patches--phagocytosis and transport of BCG by M cells into rabbit Peyer's patches.

1986 • 97 citations

Identification, genetic analysis and DNA sequence of a 7.8‐kb virulence region of the Salmonella typhimurium virulence plasmid

1992 • 89 citations

Macrophage Nitric Oxide Mediates Immunosuppression in Infectious Inflammation

1994 • 88 citations

The Salmonella typhimurium virulence plasmid encodes a positive regulator of a plasmid-encoded virulence gene

1991 • 86 citations

Salmonella typhimurium invasion of epithelial cells: role of induced host cell tyrosine protein phosphorylation

1994 • 85 citations

Anaerobic growth of Salmonella typhimurium results in increased uptake by Henle 407 epithelial and mouse peritoneal cells in vitro and repression of a major outer membrane protein

1991 • 84 citations

Molecular analysis of the virulence locus of the Salmonella dublin plasmid pSDL2

1991 • 83 citations

Intestinal Perforation in Typhoid Fever: A Historical and State-of-the-Art Review

1985 • 83 citations

Salmonella typhimuriuminduces an inositol phosphate flux in infected epithelial cells

1992 • 83 citations

Cytochalasins; Biochemical and Cell Biological Aspects

1979 • 83 citations

Second attacks of typhoid fever

1953 • 81 citations

The primary effect of the Ity locus is on the rate of growth of Salmonella typhimurium that are relatively protected from killing.

1990 • 76 citations

Structural specializations for antigen uptake and processing in the digestive tract

1990 • 74 citations

Macrophage-inducible expression of a model antigen in Salmonella typhimurium enhances immunogenicity.

1995 • 73 citations

Specific inhibition of phagosome-lysosome fusion in murine macrophages mediated bySalmonella typhimuriuminfection

1990 • 71 citations

Functional morphology of microfold cells (M cells) in Peyer’s patches

1986 • 70 citations

Interferon gamma (IFN-γ) production by gut-associated lymphoid tissue and spleen following oral Salmonella typhimurium challenge

1991 • 70 citations

Gamma interferon production in endotoxin-responder and -nonresponder mice during infection

1991 • 69 citations

Identification of an essential virulence region on Salmonella plasmids

1988 • 68 citations

The antibody response to salmonellae in mice and humans studied by immunoblots and ELISA

1989 • 67 citations

T cells do not mediate the initial suppression of a Salmonella infection in the RES.

1990 • 65 citations

Functional histology of appendix.

1983 • 64 citations

The Human Humoral Immune Response to Salmonella typhi Ty2la

1991 • 63 citations

Macrophage-mediated mitogenic suppression induced in mice of the C3H lineage by a vaccine strain of Salmonella typhimurium

1985 • 58 citations

A Molecular Strategy for the Study of Bacterial Invasion

1987 • 57 citations

Nucleotide sequence of a plasmid gene involved in the virulence of salmonellas

1989 • 53 citations

Invasion and lysis of HeLa cell monolayers by Salmonella typhi: the role of lipopolysaccharide

1989 • 53 citations

Selective Primary Health Care: Strategies for Control of Disease in the Developing World. XX. Typhoid Fever

1985 • 52 citations

Cellular immunity against Salmonella typhi after live oral vaccine.

1985 • 51 citations

Ity influences the production of IFN-gamma by murine splenocytes stimulated in vitro with Salmonella typhimurium.

1993 • 49 citations

Growth phase and SpvR regulation of transcription of Salmonella typhimurium spvABC virulence genes

1992 • 47 citations

Genetics of the immune response to infectious pathogens

1991 • 44 citations

Functional expression of the Bcg gene in macrophages

1989 • 42 citations

Differences in initial rate of intracellular killing of Salmonella typhimurium by resident peritoneal macrophages from various mouse strains.

1985 • 41 citations

Entrance and survival of Salmonella typhimurium and Yersinia enterocolitica within human B- and T-cell lines

1994 • 40 citations

Fluoroquinolones in the treatment of typhoid fever and the carrier state

1991 • 39 citations

Immune responses in BALB/c mice following immunization with aromatic compound or purine-dependent Salmonella typhimurium strains.

1990 • 33 citations

Immunity to Salmonella typhi: considerations relevant to measurement of cellular immunity in typhoid-endemic regions.

1989 • 31 citations

Differences in initial rate of intracellular killing of Salmonella typhimurium by granulocytes of Salmonella-susceptible C57BL/10 mice and Salmonella-resistant CBA mice.

1986 • 29 citations

Contribution of interferon γ and membrane-associated interleukin 1 to the resistance to murine typhoid of Ityr mice

1992 • 25 citations

Specific inhibition of phagosome-lysosome fusion in murine macrophages mediated by Salmonella typhimurium infection

1990 • 23 citations

Positive regulator for the expression of Mba protein of the virulence plasmid, pKDSC50, of Salmonella choleraesuis

1991 • 22 citations

In vitro treatment of HEp-2 cells with human tumor necrosis factor-alpha and human interferons reduces invasiveness of Salmonella typhimurium.

1989 • 17 citations

[The detection of chronic Salmonella typhi carriers: a practical method applied to food handlers].

1990 • 13 citations

Salmonella typhimurium induces an inositol phosphate flux in infected epithelial cells

1992 • 10 citations