Role of Melanocortin-4 Receptors in Mediating Renal Sympathoactivation to Leptin and Insulin

Central nervous system control of food intake

2000 • 6,305 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

1997 • 2,992 citations

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

1996 • 2,185 citations

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

2000 • 2,178 citations

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

1997 • 1,891 citations

The Cloning of a Family of Genes That Encode the Melanocortin Receptors

1992 • 1,616 citations

The Leptin Receptor

1997 • 1,300 citations

Neural Control of Renal Function*

2020 • 1,159 citations

Neural control of renal function

1997 • 1,144 citations

Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor

1996 • 1,074 citations

Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain.

1994 • 1,059 citations

Receptor-mediated regional sympathetic nerve activation by leptin.

1997 • 980 citations

Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus

1997 • 837 citations

Proopiomelanocortin Neurons Are Direct Targets for Leptin in the Hypothalamus

1997 • 731 citations

Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system.

1993 • 719 citations

Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain

1994 • 703 citations

Chronic Leptin Infusion Increases Arterial Pressure

1998 • 694 citations

Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

2002 • 573 citations

Response of melanocortin–4 receptor–deficient mice to anorectic and orexigenic peptides

1999 • 549 citations

Regulation of Hypothalamic Proopiomelanocortin mRNA by Leptin in ob/ob Mice

1997 • 425 citations

Intracerebroventricular Leptin Increases Lumbar and Renal Sympathetic Nerve Activity and Blood Pressure in Normal Rats

1997 • 418 citations

The Catabolic Action of Insulin in the Brain Is Mediated by Melanocortins

2002 • 406 citations

Interactions Between the Melanocortin System and Leptin in Control of Sympathetic Nerve Traffic

1999 • 367 citations

Obesity induced by a high-fat diet is associated with reduced brain insulin transport in dogs.

2000 • 314 citations

Insulin-mediated sympathetic stimulation: role in the pathogenesis of obesity-related hypertension (or, how insulin affects blood pressure, and why)

2001 • 309 citations

Proopiomelanocortin Neurons Are Direct Targets for Leptin in the Hypothalamus

1997 • 226 citations

The Concept of Selective Leptin Resistance

2002 • 221 citations

Satiety effect and sympathetic activation of leptin are mediated by hypothalamic melanocortin system

1998 • 192 citations

Substitution at Codon 269 (Glutamine → Proline) of the Leptin Receptor (OB-R) cDNA Is the Only Mutation Found in the Zucker Fatty (fa/fa) Rat

1996 • 186 citations

A Novel Selective Melanocortin-4 Receptor Agonist Reduces Food Intake in Rats and Mice without Producing Aversive Consequences

2000 • 178 citations

Regulation of Hypothalamic Proopiomelanocortin mRNA by Leptin in ob/ob Mice

1997 • 134 citations

Mechanisms of Insulin Action on Sympathetic Nerve Activity

1995 • 132 citations

Selective Resistance to Central Neural Administration of Leptin in Agouti Obese Mice

2002 • 129 citations

Interaction between leptin and sympathetic nervous system in hypertension

2000 • 121 citations

Renal Sympathetic Nerve Activity Is Increased in Obese Zucker Rats

1995 • 105 citations

Brain and Liver Insulin Binding Is Decreased in Zucker Rats Carrying the ’fa’ Gene*

1985 • 89 citations

Melanocortins and the brain: from effects via receptors to drug targets

2000 • 75 citations

Leptin injection into white adipose tissue elevates renal sympathetic nerve activity dose-dependently through the afferent nerves pathway in rats

2000 • 63 citations

Role of Corticotrophin-Releasing Factor in Effects of Leptin on Sympathetic Nerve Activity and Arterial Pressure

2001 • 61 citations

Metabolic responses to leptin in obese db/db mice are strain dependent

2001 • 58 citations

Renal Denervation Prevents and Reverses Hyperinsulinemia-Induced Hypertension in Rats

1998 • 53 citations

Genetic Factors Determine the Blood Pressure Response to Insulin Resistance and Hyperinsulinemia: A Call to Refocus the Insulin Hypothesis of Hypertension

1995 • 20 citations