TGF- and metalloproteinases differentially suppress NKG2D ligand surface expression on malignant glioma cells

New functions for the matrix metalloproteinases in cancer progression

2002 • 5,937 citations

Dissemination and growth of cancer cells in metastatic sites

2002 • 3,796 citations

Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations

2002 • 2,711 citations

Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation

2002 • 1,529 citations

Pathology and genetics of tumours of the nervous system.

2000 • 1,374 citations

Strategies for MMP inhibition in cancer: innovations for the post-trial era

2002 • 1,309 citations

The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor

2005 • 1,246 citations

ULBPs, Novel MHC Class I–Related Molecules, Bind to CMV Glycoprotein UL16 and Stimulate NK Cytotoxicity through the NKG2D Receptor

2001 • 1,190 citations

TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance

2005 • 1,173 citations

ADAMs: key components in EGFR signalling and development

2005 • 1,056 citations

Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium.

1996 • 1,010 citations

Broad tumor-associated expression and recognition by tumor-derived γδ T cells of MICA and MICB

1999 • 1,006 citations

Costimulation of CD8αβ T cells by NKG2D via engagement by MIC induced on virus-infected cells

2001 • 937 citations

The ADAMTS metalloproteinases

2005 • 761 citations

Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells

2001 • 759 citations

Transforming growth factor β1 inhibits expression of NKp30 and NKG2D receptors: Consequences for the NK-mediated killing of dendritic cells

2003 • 639 citations

Cutting Edge: Down-Regulation of MICA on Human Tumors by Proteolytic Shedding

2002 • 624 citations

Elevated TGF-β1 Secretion and Down-Modulation of NKG2D Underlies Impaired NK Cytotoxicity in Cancer Patients

2004 • 518 citations

Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia

2003 • 510 citations

Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity.

2002 • 509 citations

Shedding light on ADAM metalloproteinases

2005 • 449 citations

Local distribution of microglia in the normal adult human central nervous system differs by up to one order of magnitude

2001 • 427 citations

SD-208, a Novel Transforming Growth Factor β Receptor I Kinase Inhibitor, Inhibits Growth and Invasiveness and Enhances Immunogenicity of Murine and Human Glioma CellsIn vitroandIn vivo

2004 • 407 citations

MICA Engagement by Human Vγ2Vδ2 T Cells Enhances Their Antigen-Dependent Effector Function

2001 • 394 citations

Immunosuppression and transforming growth factor-beta in glioblastoma. Preferential production of transforming growth factor-beta 2.

1989 • 391 citations

Complex structure of the activating immunoreceptor NKG2D and its MHC class I–like ligand MICA

2001 • 389 citations

Control of adaptive immune responses by Toll-like receptors

2002 • 335 citations

Prevalent expression of the immunostimulatory MHC class I chain–related molecule is counteracted by shedding in prostate cancer

2004 • 297 citations

RNA Interference Targeting Transforming Growth Factor-β Enhances NKG2D-Mediated Antiglioma Immune Response, Inhibits Glioma Cell Migration and Invasiveness, and Abrogates TumorigenicityIn vivo

2004 • 288 citations

ABCC Drug Efflux Pumps and Organic Anion Uptake Transporters in Human Gliomas and the Blood-Tumor Barrier

2005 • 286 citations

Glioma cell invasion: regulation of metalloproteinase activity by TGF-beta.

2001 • 259 citations

Downregulation and/or Release of NKG2D Ligands as Immune Evasion Strategy of Human Neuroblastoma

2004 • 254 citations

Selective intracellular retention of virally induced NKG2D ligands by the human cytomegalovirus UL16 glycoprotein

2002 • 240 citations

The failure of current immunotherapy for malignant glioma. Tumor-derived TGF-?, T-cell apoptosis, and the immune privilege of the brain

1995 • 233 citations

Proteolytic Release of Soluble UL16-Binding Protein 2 from Tumor Cells

2006 • 232 citations

Role of transforming growth factor beta in cancer

2001 • 232 citations

The innate immune response to tumors and its role in the induction of T‐cell immunity

2002 • 227 citations

Expression of TGF-β isoforms, TGF-β receptors, and SMAD molecules at different stages of human glioma

2000 • 223 citations

The expression of matrix metalloproteinase-2 and-9 in human gliomas of different pathological grades

2003 • 211 citations

ULBP4 is a novel ligand for human NKG2D

2003 • 201 citations

Brain-enriched Hyaluronan Binding (BEHAB)/Brevican Cleavage in a Glioma Cell Line Is Mediated by a Disintegrin and Metalloproteinase with Thrombospondin Motifs (ADAMTS) Family Member

2000 • 197 citations

The role of matrix metalloproteinases in glioma invasion

2003 • 194 citations

MICA/NKG2D-mediated immunogene therapy of experimental gliomas.

2003 • 191 citations

Cutting Edge: Tumor Rejection Mediated by NKG2D Receptor-Ligand Interaction Is Dependent upon Perforin

2002 • 181 citations

Transforming growth factor-β-induced expression of CD94/NKG2A inhibitory receptors in human T lymphocytes

1999 • 180 citations

Elevated membrane-type matrix metalloproteinases in gliomas revealed by profiling proteases and inhibitors in human cancer cells.

2003 • 176 citations

Two Human ULBP/RAET1 Molecules with Transmembrane Regions Are Ligands for NKG2D

2004 • 173 citations

ADAM12 Is Selectively Overexpressed in Human Glioblastomas and Is Associated with Glioblastoma Cell Proliferation and Shedding of Heparin-Binding Epidermal Growth Factor

2004 • 150 citations

Molecular determinants of glioma cell migration and invasion

2001 • 128 citations

Correlation of Endothelin-1 and Transforming Growth Factor β1 with Malignancy and Vascularity in Human Gliomas

1997 • 109 citations

MIC and other NKG2D ligands: from none to too many

2005 • 108 citations

Processing of Immunosuppressive Pro-TGF-β1,2 by Human Glioblastoma Cells Involves Cytoplasmic and Secreted Furin-Like Proteases

2001 • 96 citations

Expression of toll‐like receptors by human muscle cells in vitro and in vivo: TLR3 is highly expressed in inflammatory and HIV myopathies, mediates IL‐8 release, and up‐regulation of NKG2D‐ligands

2005 • 89 citations

Expression of MMP-2, MMP-7, MMP-9, MMP-10 and MMP-11 in human astrocytic and oligodendroglial gliomas.

2003 • 79 citations

Correlation of thrombospondin‐1 and transforming growth factor‐β expression with malignancy of glioma

2000 • 63 citations

Role of the production of natural killer cell stimulatory factor (NKSF/IL-12) in the ability of B cell lines to stimulate T and NK cell proliferation

1992 • 54 citations

ADAM proteases, ErbB pathways and cancer

2005 • 24 citations