NOX4 Regulates ROS Levels Under Normoxic and Hypoxic Conditions, Triggers Proliferation, and Inhibits Apoptosis in Pulmonary Artery Adventitial Fibroblasts

The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology

2007 • 6,348 citations

HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

2006 • 3,428 citations

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

2006 • 2,050 citations

Reactive Oxygen Species Generated at Mitochondrial Complex III Stabilize Hypoxia-inducible Factor-1α during Hypoxia

2000 • 1,860 citations

Cell transformation by the superoxide-generating oxidase Mox1

1999 • 1,457 citations

Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

2005 • 1,425 citations

Role of oxidative stress in atherosclerosis

2003 • 1,268 citations

HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells

2007 • 1,133 citations

Hypoxia-Induced Pulmonary Vascular Remodeling

2006 • 947 citations

Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases

2005 • 752 citations

Oxidant Signaling in Vascular Cell Growth, Death, and Survival

2000 • 742 citations

NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation

2007 • 591 citations

Direct Interaction of the Novel Nox Proteins with p22phox Is Required for the Formation of a Functionally Active NADPH Oxidase

2004 • 526 citations

Regulation of NADPH Oxidases

2006 • 514 citations

Two Novel Proteins Activate Superoxide Generation by the NADPH Oxidase NOX1

2003 • 477 citations

Expression of angiogenesis‐related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis

2001 • 471 citations

Superoxide dismutase and catalase conjugated to polyethylene glycol increases endothelial enzyme activity and oxidant resistance.

1988 • 425 citations

Molecular Basis of Phosphorylation-Induced Activation of the NADPH Oxidase

2003 • 393 citations

Transforming growth factor-β1 induces Nox4 NAD(P)H oxidase and reactive oxygen species-dependent proliferation in human pulmonary artery smooth muscle cells

2005 • 387 citations

A redox-based O2 sensor in rat pulmonary vasculature.

1993 • 366 citations

CELLULAR AND MOLECULAR MECHANISMS OF PULMONARY VASCULAR REMODELING

1997 • 358 citations

Reactive Oxygen Species Produced by NAD(P)H Oxidase Inhibit Apoptosis in Pancreatic Cancer Cells

2004 • 355 citations

Hypoxia-Dependent Regulation of Nonphagocytic NADPH Oxidase Subunit NOX4 in the Pulmonary Vasculature

2007 • 321 citations

Pulmonary vascular remodeling: a target for therapeutic intervention in pulmonary hypertension

2001 • 274 citations

The superoxide‐producing NAD(P)H oxidase Nox4 in the nucleus of human vascular endothelial cells

2005 • 265 citations

Regulation and termination of NADPH oxidase activity

2005 • 260 citations

Pulmonary artery NADPH-oxidase is activated in hypoxic pulmonary vasoconstriction.

1996 • 260 citations

ET-1 stimulates pulmonary arterial smooth muscle cell proliferation via induction of reactive oxygen species

2001 • 249 citations

NOX2 and NOX4 Mediate Proliferative Response in Endothelial Cells

2006 • 237 citations

Molecular Characterization and Localization of the NAD(P)H Oxidase Components gp91- phox and p22- phox in Endothelial Cells

2000 • 235 citations

Point Mutations in the Proline-rich Region of p22 Are Dominant Inhibitors of Nox1- and Nox2-dependent Reactive Oxygen Generation

2005 • 224 citations

Assembly and Activation of the Phagocyte NADPH Oxidase

1996 • 184 citations

Effects of oxygen tension and pH on the respiratory burst of human neutrophils

1979 • 183 citations

Oxidant and redox signaling in vascular oxygen sensing mechanisms: basic concepts, current controversies, and potential importance of cytosolic NADPH

2005 • 182 citations

Upregulation of NAD(P)H oxidase 1 in hypoxia activates hypoxia-inducible factor 1 via increase in reactive oxygen species

2004 • 181 citations

NAD(P)H Oxidase Mediates Angiotensin II–Induced Vascular Macrophage Infiltration and Medial Hypertrophy

2003 • 181 citations

Essential role of complex II of the respiratory chain in hypoxia-induced ROS generation in the pulmonary vasculature

2003 • 178 citations

Nox1 Mediates Basic Fibroblast Growth Factor-Induced Migration of Vascular Smooth Muscle Cells

2007 • 143 citations

Cytosolic NADPH may regulate differences in basal Nox oxidase-derived superoxide generation in bovine coronary and pulmonary arteries

2004 • 125 citations

Free radical production in hypoxic pulmonary artery smooth muscle cells

2000 • 119 citations

Hypoxia induces differentiation of pulmonary artery adventitial fibroblasts into myofibroblasts

2004 • 111 citations

Mechanisms of Structural Remodeling in Chronic Pulmonary Hypertension

1999 • 109 citations

NOX4 as an oxygen sensor to regulate TASK-1 activity

2005 • 107 citations

Reactive oxygen species alter contractile properties of pulmonary arterial smooth muscle

1990 • 106 citations

Hypoxic pulmonary artery fibroblasts trigger proliferation of vascular smooth muscle cells‐role of hypoxia‐inducible transcription factors

2002 • 105 citations

Endogenous production of superoxide by rabbit lungs: effects of hypoxia or metabolic inhibitors

1993 • 101 citations

Identification of novel Nox4 splice variants with impact on ROS levels in A549 cells

2005 • 96 citations

Impact of Mitochondria and NADPH Oxidases on Acute and Sustained Hypoxic Pulmonary Vasoconstriction

2005 • 91 citations

NADPH Oxidase Is Involved in Prostaglandin F2α-induced Hypertrophy of Vascular Smooth Muscle Cells

2002 • 88 citations

Urokinase Plasminogen Activator Stimulates Vascular Smooth Muscle Cell Proliferation Via Redox-Dependent Pathways

2006 • 70 citations

Chronic Hypoxia Induces Exaggerated Growth Responses in Pulmonary Artery Adventitial Fibroblasts

2000 • 66 citations

Hypoxia divergently regulates production of reactive oxygen species in human pulmonary and coronary artery smooth muscle cells

2007 • 59 citations

TLR4-NOX4-AP-1 signaling mediates lipopolysaccharide-induced CXCR6 expression in human aortic smooth muscle cells

2006 • 53 citations

Superoxide in the pulmonary circulation

1999 • 48 citations

Local production of O2− by NAD(P)H oxidase in the sarcoplasmic reticulum of coronary arterial myocytes: cADPR-mediated Ca2+ regulation

2007 • 40 citations