Point Mutations in the Proline-rich Region of p22 Are Dominant Inhibitors of Nox1- and Nox2-dependent Reactive Oxygen Generation

NOX enzymes and the biology of reactive oxygen

2004 • 2,940 citations

NADPH Oxidase: An Update

1999 • 2,134 citations

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

2002 • 1,526 citations

Cell transformation by the superoxide-generating oxidase Mox1

1999 • 1,457 citations

Reactive Oxygen Species in the Vasculature

2003 • 1,052 citations

The Neutrophil NADPH Oxidase

2002 • 904 citations

Identification of Renox, an NAD(P)H oxidase in kidney

2000 • 824 citations

Homologs of gp91 phox : cloning and tissue expression of Nox3, Nox4, and Nox5

2001 • 794 citations

Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cells

2004 • 707 citations

Cloning of Two Human Thyroid cDNAs Encoding New Members of the NADPH Oxidase Family

2000 • 611 citations

Cutting Edge: Direct Interaction of TLR4 with NAD(P)H Oxidase 4 Isozyme Is Essential for Lipopolysaccharide-Induced Production of Reactive Oxygen Species and Activation of NF-κB

2004 • 609 citations

A Ca2+-activated NADPH Oxidase in Testis, Spleen, and Lymph Nodes

2001 • 598 citations

A Plant Homolog of the Neutrophil NADPH Oxidase gp91^phox Subunit Gene Encodes a Plasma Membrane Protein with Ca²⁺ Binding Motifs

1998 • 590 citations

Expression of a Functionally Active gp91phox-Containing Neutrophil-Type NAD(P)H Oxidase in Smooth Muscle Cells From Human Resistance Arteries

2002 • 589 citations

Nicotiana benthamiana gp91^phox Homologs NbrbohA and NbrbohB Participate in H₂O₂ Accumulation and Resistance to Phytophthora infestans

2003 • 585 citations

Direct Interaction of the Novel Nox Proteins with p22phox Is Required for the Formation of a Functionally Active NADPH Oxidase

2004 • 526 citations

A Novel Superoxide-producing NAD(P)H Oxidase in Kidney

2001 • 508 citations

The NAD(P)H Oxidase Homolog Nox4 Modulates Insulin-Stimulated Generation of H₂O₂ and Plays an Integral Role in Insulin Signal Transduction

2004 • 506 citations

Two Novel Proteins Activate Superoxide Generation by the NADPH Oxidase NOX1

2003 • 477 citations

Structure and regulation of the neutrophil respiratory burst oxidase: comparison with nonphagocyte oxidases

2004 • 475 citations

NOX3, a Superoxide-generating NADPH Oxidase of the Inner Ear

2004 • 432 citations

Molecular Basis of Phosphorylation-Induced Activation of the NADPH Oxidase

2003 • 393 citations

Mechanism of Ca2+ Activation of the NADPH Oxidase 5 (NOX5)

2004 • 371 citations

Novel Human Homologues of p47 and p67 Participate in Activation of Superoxide-producing NADPH Oxidases

2003 • 366 citations

Current molecular models for NADPH oxidase regulation by Rac GTPase

2002 • 335 citations

Regulation of the Erythropoietin Gene

1999 • 311 citations

Regulation of the Erythropoietin Gene

1989 • 305 citations

Molecular basis for Rac2 regulation of phagocyte NADPH oxidase

2001 • 300 citations

A Mammalian H ⁺ Channel Generated Through Alternative Splicing of the NADPH Oxidase Homolog NOH-1

2000 • 295 citations

The Superoxide-Generating Oxidase Nox1 Is Functionally Required for Ras Oncogene Transformation

2004 • 295 citations

Role of Src homology 3 domains in assembly and activation of the phagocyte NADPH oxidase.

1994 • 286 citations

Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline-rich targets.

1994 • 285 citations

Nox/Duox family of nicotinamide adenine dinucleotide (phosphate) oxidases

2002 • 281 citations

Proteins Homologous to p47 and p67 Support Superoxide Production by NAD(P)H Oxidase 1 in Colon Epithelial Cells

2003 • 274 citations

Rac translocates independently of the neutrophil NADPH oxidase components p47phox and p67phox. Evidence for its interaction with flavocytochrome b558.

1994 • 260 citations

Vestibular defects in head-tilt mice result from mutations inNox3, encoding an NADPH oxidase

2004 • 260 citations

Capacitation-associated production of superoxide anion by human spermatozoa

1995 • 259 citations

Regulation of the Neutrophil Respiratory Burst Oxidase

1998 • 209 citations

NOXO1, Regulation of Lipid Binding, Localization, and Activation of Nox1 by the Phox Homology (PX) Domain

2004 • 203 citations

The p67 Activation Domain Regulates Electron Flow from NADPH to Flavin in Flavocytochromeb 558

1999 • 194 citations

Assembly and Activation of the Phagocyte NADPH Oxidase

1996 • 184 citations

Characterization of ThOX Proteins as Components of the Thyroid H2O2-Generating System

2002 • 182 citations

The NADPH Oxidase Nox3 Constitutively Produces Superoxide in a p22 -dependent Manner

2005 • 180 citations

Role of NADPH Oxidase in the Mechanism of Lung Neutrophil Sequestration and Microvessel Injury Induced by Gram-Negative Sepsis: Studies in p47phox−/− and gp91phox−/− Mice

2002 • 178 citations

The importance of redox regulated pathways in sperm cell biology

2004 • 170 citations

T Cell Receptor Stimulation, Reactive Oxygen Species, and Cell Signaling

2004 • 167 citations

The H2O2-Generating System Modulates Protein Iodination and the Activity of the Pentose Phosphate Pathway in Dog Thyroid*

1991 • 158 citations

Nox3 Regulation by NOXO1, p47 , and p67

2004 • 156 citations

The adaptor protein p40phox as a positive regulator of the superoxide-producing phagocyte oxidase

2002 • 150 citations

Ultrastructural localization of cytochrome b in the membranes of resting and phagocytosing human granulocytes.

1990 • 145 citations

Helicobacter pylori lipopolysaccharide activates Rac1 and transcription of NADPH oxidase Nox1 and its organizer NOXO1 in guinea pig gastric mucosal cells

2004 • 141 citations

Fungal Metabolite Gliotoxin Inhibits Assembly of the Human Respiratory Burst NADPH Oxidase

2004 • 136 citations

Role of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 1 in Oxidative Burst Response to Toll-Like Receptor 5 Signaling in Large Intestinal Epithelial Cells

2004 • 135 citations

Superoxide and bone resorption

1994 • 133 citations

Transforming growth factor-β inhibition of proteasomal activity: a potential mechanism of growth arrest

2003 • 132 citations

The Respiratory Burst Oxidase and the Molecular Genetics of Chronic Granulomatous Disease

1993 • 130 citations

156Pro-->Gln substitution in the light chain of cytochrome b558 of the human NADPH oxidase (p22-phox) leads to defective translocation of the cytosolic proteins p47-phox and p67-phox.

1994 • 107 citations

Point mutation in the cytoplasmic domain of the neutrophil p22-phox cytochrome b subunit is associated with a nonfunctional NADPH oxidase and chronic granulomatous disease.

1991 • 99 citations

Deficiency of NADPH Oxidase Components p47phox and gp91phox Caused Granulomatous Synovitis and Increased Connective Tissue Destruction in Experimental Arthritis Models

2003 • 93 citations

Gene Transfer of NAD(P)H Oxidase Inhibitor to the Vascular Adventitia Attenuates Medial Smooth Muscle Hypertrophy

2004 • 91 citations

The FlyBase database of the Drosophila genome projects and community literature

2002 • 87 citations

The use of model systems to study biological functions of Nox/Duox enzymes

2004 • 22 citations