Predicting new molecular targets for known drugs

Basic local alignment search tool

1990 • 87,358 citations

Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks

2003 • 41,909 citations

ZINC − A Free Database of Commercially Available Compounds for Virtual Screening

2004 • 3,660 citations

Relating protein pharmacology by ligand chemistry

2007 • 1,915 citations

The Expanded Biology of Serotonin

2009 • 1,766 citations

A double‐blind, placebo‐controlled trial

1986 • 1,281 citations

Drug Target Identification Using Side-Effect Similarity

2008 • 1,200 citations

Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

2004 • 1,111 citations

Global mapping of pharmacological space

2006 • 798 citations

Salvinorin A: A potent naturally occurring nonnitrogenous κ opioid selective agonist

2002 • 740 citations

Natural Products as Leads to Potential Drugs: An Old Process or the New Hope for Drug Discovery?

2008 • 696 citations

Chemical proteomic profiles of the BCR-ABL inhibitors imatinib, nilotinib, and dasatinib reveal novel kinase and nonkinase targets

2007 • 638 citations

Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor.

1988 • 566 citations

The Hallucinogen N,N -Dimethyltryptamine (DMT) Is an Endogenous Sigma-1 Receptor Regulator

2009 • 477 citations

Protein promiscuity and its implications for biotechnology

2009 • 474 citations

Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5.

1991 • 401 citations

Cloning, Characterization, and Chromosomal Localization of a Human 5‐HT₆ Serotonin Receptor

1996 • 370 citations

Effect of SSRI Antidepressants on Ejaculation

1998 • 359 citations

Integrating high-content screening and ligand-target prediction to identify mechanism of action

2007 • 338 citations

The Multiplicity of Serotonin Receptors: Uselessly Diverse Molecules or an Embarrassment of Riches?

2000 • 332 citations

N-Desalkylquetiapine, a Potent Norepinephrine Reuptake Inhibitor and Partial 5-HT1A Agonist, as a Putative Mediator of Quetiapine's Antidepressant Activity

2007 • 307 citations

Large-scale chemical dissection of mitochondrial function

2008 • 199 citations

Predicting ADME properties and side effects: the BioPrint approach.

2003 • 176 citations

Interruption of selective serotonin reuptake inhibitor treatment

2000 • 173 citations

Quantifying the Relationships among Drug Classes

2008 • 166 citations

A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore

2009 • 153 citations

Pharmacological Promiscuity: Dependence on Compound Properties and Target Specificity in a Set of Recent Roche Compounds

2009 • 149 citations

Hallucinogenic drug interactions with neurotransmitter receptor binding sites in human cortex

1989 • 142 citations

Systems chemical biology

2007 • 139 citations

Agonist Properties of N,N-Dimethyltryptamine at Serotonin 5-HT2A and 5-HT2C Receptors

1998 • 136 citations

PSD-95 Is Essential for Hallucinogen and Atypical Antipsychotic Drug Actions at Serotonin Receptors

2009 • 118 citations

State dependent dissociation of HERG channel inhibitors

2007 • 112 citations

Human Inflammatory Dendritic Epidermal Cells Express a Functional Histamine H4 Receptor

2008 • 112 citations

On the pharmacokinetics of domperidone in animals and man IV. The pharmacokinetics of intravenous domperidone and its bioavailability in man following intramuscular, oral and rectal administration

1981 • 108 citations

Ligand-Target Prediction Using Winnow and Naive Bayesian Algorithms and the Implications of Overall Performance Statistics

2008 • 104 citations

When the Endogenous Hallucinogenic Trace Amine N,N -Dimethyltryptamine Meets the Sigma-1 Receptor

2009 • 101 citations

Delavirdine

2000 • 96 citations

Chemoinformatics in drug discovery

2005 • 96 citations

An Ontology for Pharmaceutical Ligands and Its Application for in Silico Screening and Library Design

2002 • 93 citations

Chemical biology : from small molecules to systems biology and drug design

2007 • 91 citations

Computational analysis of ligand relationships within target families

2008 • 88 citations

Drugs in other drugs: a new look at drugs as fragments

2006 • 73 citations

Chemical biology and the limits of reductionism

2008 • 70 citations

Further evidence that the delayed temporal dopaminergic effects of LSD are mediated by a mechanism different than the first temporal phase of action

2007 • 65 citations

Pharmacokinetics of tetrabenazine and its major metabolite in man and rat. Bioavailability and dose dependency studies.

1987 • 47 citations

Repurposing libraries of eukaryotic protein kinase inhibitors for antibiotic discovery

2009 • 34 citations

WAY 100635 produces discriminative stimulus effects in rats mediated by dopamine D4 receptor activation

2009 • 28 citations

Beta1-adrenergic selectivity of the new cardiotonic agent denopamine in its stimulating effects on adenylate cyclase

1987 • 19 citations

Clinical Trial of Haloanisone (R‐2028) with Hospitalized Psychiatric Patients

1962 • 4 citations

[The effect of antihistaminic preparations on the binding of labelled mepyramine, ketanserin and quinuclidinyl benzilate in the rat brain].

1993 • 3 citations

Effect of some antihistamine preparations on binding of3H-mepyramine and3H-cimetidine to histamine receptors in rat brain

1992 • 2 citations