Chemical biology and the limits of reductionism

The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease

2006 • 4,789 citations

Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis

2007 • 1,066 citations

The Chemical Genomic Portrait of Yeast: Uncovering a Phenotype for All Genes

2008 • 1,011 citations

Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism

2007 • 975 citations

High-throughput assays for promiscuous inhibitors

2005 • 328 citations

Parallel Chemical Genetic and Genome-Wide RNAi Screens Identify Cytokinesis Inhibitors and Targets

2004 • 320 citations

ChemBank: a small-molecule screening and cheminformatics resource database

2007 • 274 citations

A small-molecule screen in C. elegans yields a new calcium channel antagonist

2006 • 273 citations

Identification of Genetic and Chemical Modulators of Zebrafish Mechanosensory Hair Cell Death

2008 • 210 citations

An integrated platform of genomic assays reveals small-molecule bioactivities

2008 • 198 citations

Small molecules that delay S phase suppress a zebrafish bmyb mutant

2005 • 168 citations

Reporting data from high-throughput screening of small-molecule libraries

2007 • 105 citations

Chemogenomic Data Analysis: Prediction of Small-Molecule Targets and the Advent of Biological Fingerprints

2007 • 100 citations

Turning promiscuous kinase inhibitors into safer drugs

2008 • 57 citations

Commentary: Novel Therapies for Cancer: Why Dirty Might Be Better

2008 • 55 citations

Utilizing high throughput screening data for predictive toxicology models: protocols and application to MLSCN assays

2008 • 46 citations

Large-Scale Annotation of Small-Molecule Libraries Using Public Databases

2007 • 42 citations

A Cheminformatic Toolkit for Mining Biomedical Knowledge

2007 • 27 citations

Gene regulation technologies in zebrafish

2008 • 16 citations