Inhibition of cholesterol synthesis with compactin renders growth of cultured cells dependent on the low density lipoprotein receptor.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis

1977 • 2,481 citations

Binding and Degradation of Low Density Lipoproteins by Cultured Human Fibroblasts

1974 • 1,481 citations

Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts.

1976 • 1,032 citations

Competitive inhibition of 3‐hydroxy‐3‐methylglutaryl coenzyme a reductase by ML‐236A and ML‐236B fungal metabolites, having hypocholesterolemic activity

1976 • 788 citations

Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase

1978 • 556 citations

Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Activity in Cultured Human Fibroblasts

1974 • 545 citations

Suppression of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Activity and Inhibition of Growth of Human Fibroblasts by 7-Ketocholesterol

1974 • 502 citations

Regulation of the activity of the low density lipoprotein receptor in human fibroblasts

1975 • 477 citations

Cholesterol ester formation in cultured human fibroblasts. Stimulation by oxygenated sterols.

1975 • 364 citations

Crystal and molecular structure of compactin, a new antifungal metabolite from Penicillium brevicompactum

1976 • 351 citations

Role of the low density lipoprotein receptor in regulating the content of free and esterified cholesterol in human fibroblasts.

1975 • 317 citations

Inhibitory Effects on Lipid Metabolismn in Cultured Cells of ML‐236B, a Potent Inhibitor of 3‐Hydroxt‐3‐methylglutaryl‐Cornzyme‐A Reductase

1978 • 252 citations

Receptor-mediated uptake of low density lipoprotein and utilization of its cholesterol for steroid synthesis in cultured mouse adrenal cells.

1977 • 239 citations

Inhibition of cell growth by oxygenated derivatives of cholesterol

1974 • 219 citations

Replacement of endogenous cholesteryl esters of low density lipoprotein with exogenous cholesteryl linoleate. Reconstitution of a biologically active lipoprotein particle.

1978 • 195 citations

Lipid Metabolism in Mammals

1977 • 184 citations

Synthesis of ubiquinone and cholesterol in human fibroblasts: Regulation of a branched pathway

1979 • 152 citations

Lipid exchange and transfer between biological lipid-protein structures

1978 • 92 citations

Inhibition of the binding of low‐density lipoprotein to its cell surface receptor in human fibroblasts by positively charged proteins

1978 • 77 citations

Lack of correlation between the rate of cholesterol biosynthesis and the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase in rats and in fibroblasts treated with ML-236B

1978 • 52 citations

Cholesterol in membranes: Studies with mycoplasmas

1978 • 44 citations

SPECIFIC INHIBITION OF DESMOSTEROL SYNTHESIS BY ML-236B IN MOUSE LM CELLS GROWN IN SUSPENSION IN A LIPID-FREE MEDIUM

1978 • 17 citations