Conformational changes in the receptors for epidermal growth factor and asialoglycoproteins induced by the mildly acidic pH found in endocytic vesicles.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ

1979 • 2,166 citations

Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents.

1978 • 2,146 citations

Coated pits, coated vesicles, and receptor-mediated endocytosis

1979 • 2,073 citations

125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts.

1976 • 1,293 citations

Epidermal Growth Factor and a New Derivative

1972 • 1,225 citations

pH and the recycling of transferrin during receptor-mediated endocytosis.

1983 • 1,165 citations

Membrane properties of living mammalian cells as studied by enzymatic hydrolysis of fluorogenic esters.

1966 • 1,150 citations

Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor

1982 • 1,138 citations

Epidermal growth factor-receptor-protein kinase interactions. Co-purification of receptor and epidermal growth factor-enhanced phosphorylation activity.

1980 • 853 citations

On the entry of semliki forest virus into BHK-21 cells

1980 • 808 citations

Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells.

1980 • 798 citations

Growth stimulation of A431 cells by epidermal growth factor: identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody.

1983 • 792 citations

Chloroquine inhibits lysosomal enzyme pinocytosis and enhances lysosomal enzyme secretion by impairing receptor recycling.

1980 • 743 citations

THE ENZYMATIC IODINATION OF THE RED CELL MEMBRANE

1972 • 709 citations

Phospholipid vesicle formation and transmembrane protein incorporation using octyl glucoside

1981 • 678 citations

Stimulation of tyrosine-specific phosphorylation by platelet-derived growth factor

1982 • 675 citations

Rapid acidification of endocytic vesicles containing α2-macroglobulin

1982 • 672 citations

Nerve growth factor receptors on human melanoma cells in culture.

1977 • 670 citations

The Isolation and Properties of a Rabbit Liver Binding Protein Specific for Asialoglycoproteins

1974 • 614 citations

Visualization by fluorescence of the binding and internalization of epidermal growth factor in human carcinoma cells A-431.

1978 • 578 citations

Receptor-mediated endocytosis of transferrin in K562 cells.

1983 • 576 citations

Cell fusion by Semliki Forest, influenza, and vesicular stomatitis viruses.

1981 • 569 citations

Weak bases and ionophores rapidly and reversibly raise the pH of endocytic vesicles in cultured mouse fibroblasts.

1982 • 569 citations

Rapid enhancement of protein phosphorylation in A-431 cell membrane preparations by epidermal growth factor.

1979 • 530 citations

Receptor-mediated endocytosis of transferrin and the uptake of fe in K562 cells: identification of a nonlysosomal acidic compartment.

1982 • 486 citations

The galactose-specific recognition system of mammalian liver: The route of ligand internalization in rat hepatocytes

1980 • 484 citations

Diphtheria toxin entry into cells is facilitated by low pH.

1980 • 467 citations

The receptosome: An intermediate organelle of receptor-mediated endocytosis in cultured fibroblasts

1980 • 398 citations

Pathway of vesicular stomatitis virus entry leading to infection

1982 • 375 citations

The entry of diphtheria toxin into the mammalian cell cytoplasm: evidence for lysosomal involvement.

1980 • 372 citations

Collection of insulin, EGF and α2-Macroglobulin in the same patches on the surface of cultured fibroblasts and common internalization

1978 • 372 citations

Externally disposed plasma membrane proteins. I. Enzymatic iodination of mouse L cells.

1975 • 353 citations

pH-dependent fusion between the Semliki Forest virus membrane and liposomes.

1980 • 344 citations

A monoclonal antibody to the human epidermal growth factor receptor

1982 • 342 citations

Catalysis of iodination by lactoperoxidase

1970 • 300 citations

Membrane fusion activity of influenza virus.

1982 • 282 citations

Chemical and physical properties of an hepatic membrane protein that specifically binds asialoglycoproteins.

1976 • 244 citations

Phosphomannosyl-enzyme receptors in rat liver. Subcellular distribution and role in intracellular transport of lysosomal enzymes.

1980 • 231 citations

Characterization of insulin-mediated phosphorylation of the insulin receptor in a cell-free system.

1983 • 223 citations

Monoclonal antibodies against receptor for epidermal growth factor induce early and delayed effects of epidermal growth factor.

1981 • 191 citations

Fluorometric Determination of Lipase, Acylase, Alpha-, and Gamma-Chymotrypsin and Inhibitors of These Enzymes.

1964 • 181 citations

Intracellular dissociation of receptor-bound asialoglycoproteins in cultured hepatocytes. A pH-mediated nonlysosomal event.

1983 • 176 citations

Interaction of influenza virus hemagglutinin with target membrane lipids is a key step in virus-induced hemolysis and fusion at pH 5.2.

1981 • 173 citations

Rapid acidification of endocytic vesicles containing asialoglycoprotein in cells of a human hepatoma line.

1983 • 155 citations

Identification of epidermal growth factor receptors in a hyperproducing human epidermoid carcinoma cell line.

1979 • 153 citations

Characterization of platelet-derived growth factor-stimulated phosphorylation in cell membranes.

1983 • 147 citations

Difference between the two iron-binding sites of transferrin

1975 • 142 citations

The Effect of pH upon Human Transferrin: Selective Labelling of the Two Iron‐binding Sites

1976 • 137 citations

Photochemical labeling of the surface proteins of human erythrocytes

1974 • 131 citations

Morphologic study of the internalization of a lysosomal enzyme by the mannose 6-phosphate receptor in cultured Chinese hamster ovary cells.

1981 • 131 citations

Intracellular polypeptide hormone receptors. Characterization of insulin binding sites in Golgi fractions from the liver of female rats.

1978 • 123 citations

Evidence for both prelysosomal and lysosomal intermediates in endocytic pathways.

1984 • 81 citations

Isolation of the human placenta receptor for epidermal growth factor-urogastrone

1979 • 80 citations

The activation reaction of papain

1967 • 73 citations

Epidermal growth factor receptor. Characterization of a monoclonal antibody specific for the receptor of A431 cells.

1983 • 60 citations

Effect of pH and iron content of transferrin on its binding to reticulocyte receptors

1983 • 59 citations

Coated vesicles from rat liver and calf brain contain lysosomal enzymes bound to mannose 6-phosphate receptors.

1983 • 58 citations

Voltage-dependent translocation of the asialoglycoprotein receptor across lipid membranes

1980 • 49 citations

Study of protein topography with flash photolytically generated nonspecific surface-labeling reagents: surface labeling of ribonuclease A

1977 • 44 citations

Topography of rhodopsin in rod outer segment disk membranes. Photochemical labeling with N-(4-azido-2-nitrophenyl)-2-aminoethylsulfonate

1980 • 44 citations

pH-dependence and structure–activity relationships in the papain-catalysed hydrolysis of anilides

1971 • 41 citations

The effect of salts upon the pH dependence of the activity of papain and succinyl-papain

1972 • 37 citations

Evidence that Sindbis virus infects BHK-21 cells via a lysosomal route

1980 • 27 citations

Reconstitution of the hepatic asialoglycoprotein receptor with phospholipid vesicles.

1980 • 21 citations

Voltage‐dependent orientation of membrane proteins

1983 • 18 citations