An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin–polymerizing machine

Cell Signaling by Receptor Tyrosine Kinases

2010 • 7,477 citations

Cell Signaling by Receptor Tyrosine Kinases

2000 • 3,570 citations

The Interaction between N-WASP and the Arp2/3 Complex Links Cdc42-Dependent Signals to Actin Assembly

1999 • 1,332 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

1997 • 1,064 citations

Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav

1998 • 798 citations

Ras and Rho GTPases

2000 • 779 citations

WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac

1998 • 696 citations

Integration of Multiple Signals Through Cooperative Regulation of the N-WASP-Arp2/3 Complex

2000 • 512 citations

Activation by Cdc42 and Pip2 of Wiskott-Aldrich Syndrome Protein (Wasp) Stimulates Actin Nucleation by Arp2/3 Complex

2000 • 498 citations

Afadin: A Novel Actin Filament–binding Protein with One PDZ Domain Localized at Cadherin-based Cell-to-Cell Adherens Junction

1997 • 473 citations

Coupling of Ras and Rac Guanosine Triphosphatases Through the Ras Exchanger Sos

1998 • 452 citations

EPS8 and E3B1 transduce signals from Ras to Rac

1999 • 329 citations

Effects of cytochalasin, phalloidin and pH on the elongation of actin filaments

1991 • 329 citations

ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements

1999 • 315 citations

Regulation of Phosphorylation Pathways by p21 GTPases

1996 • 300 citations

The COOH terminus of the c-Abl tyrosine kinase contains distinct F- and G-actin binding domains with bundling activity [published erratum appears in J Cell Biol 1994 Mar;124(5):865]

1994 • 271 citations

Actin polymerization. The mechanism of action of cytochalasin D.

1986 • 266 citations

Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2

1998 • 265 citations

Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activity.

1995 • 251 citations

NEW EMBO MEMBERS' REVIEW: Signaling from Ras to Rac and beyond: not just a matter of GEFs

2000 • 219 citations

Vav2 Activates Rac1, Cdc42, and RhoA Downstream from Growth Factor Receptors but Not β1 Integrins

2000 • 191 citations

A novel peptide-SH3 interaction

1999 • 188 citations

Control of Intramolecular Interactions between the Pleckstrin Homology and Dbl Homology Domains of Vav and Sos1 Regulates Rac Binding

2000 • 185 citations

Eps8, a substrate for the epidermal growth factor receptor kinase, enhances EGF-dependent mitogenic signals.

1993 • 179 citations

How WASP-family proteins and the Arp2/3 complex convert intracellular signals into cytoskeletal structures

2000 • 174 citations

Vav Family Proteins Couple to Diverse Cell Surface Receptors

2000 • 148 citations

Developments in matrix-assisted laser desorption/ionization peptide mass spectrometry

1996 • 115 citations

ARF6 Is Required for Growth Factor- and Rac-Mediated Membrane Ruffling in Macrophages at a Stage Distal to Rac Membrane Targeting

1999 • 106 citations

Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth

1997 • 100 citations

The cytoskeleton: A practical approach

1993 • 82 citations

Nexilin: A Novel Actin Filament-binding Protein Localized at Cell–Matrix Adherens Junction

1998 • 67 citations

The carboxy-terminal domains of erbB-2 and epidermal growth factor receptor exert different regulatory effects on intrinsic receptor tyrosine kinase function and transforming activity.

1990 • 66 citations

Abl Interactor 1 Binds to Sos and Inhibits Epidermal Growth Factor- and v-Abl-Induced Activation of Extracellular Signal-Regulated Kinases

2000 • 65 citations

The Sos (Son of sevenless) protein

1994 • 47 citations

Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors

2000 • 42 citations

Eps8, a Tyrosine Kinase Substrate, Is Recruited to the Cell Cortex and Dynamic F-Actin upon Cytoskeleton Remodeling

1998 • 32 citations

[26] Expression and properties of ADP-ribosylation factor (ARF6) in endocytic pathways

2001 • 21 citations

The Carboxy-Terminal Domains of erbB-2 and Epidermal Growth Factor Receptor Exert Different Regulatory Effects on Intrinsic Receptor Tyrosine Kinase Function and Transforming Activity

1990 • 18 citations