Human Intestinal Mast Cells Are Capable of Producing Different Cytokine Profiles: Role of IgE Receptor Cross-Linking and IL-4

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

Mast cells

1997 • 1,636 citations

Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-α

1996 • 1,121 citations

New Concepts about the Mast Cell

1993 • 1,009 citations

Critical protective role of mast cells in a model of acute septic peritonitis

1996 • 942 citations

Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines.

1994 • 850 citations

Mast cells as a source of multifunctional cytokines

1990 • 708 citations

Interleukin 4 is localized to and released by human mast cells.

1992 • 589 citations

Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects. The mast cell as a source of IL-4, IL-5, and IL-6 in human allergic mucosal inflammation.

1993 • 561 citations

Interleukin-18 (IFNgamma-inducing factor) induces IL-8 and IL-1beta via TNFalpha production from non-CD14+ human blood mononuclear cells.

1998 • 556 citations

Biology of human TH1 and TH2 cells

1995 • 408 citations

Human peripheral blood basophils primed by interleukin 3 (IL-3) produce IL-4 in response to immunoglobulin E receptor stimulation.

1993 • 391 citations

Nasal mast cells in perennial allergic rhinitics exhibit increased expression of the Fc epsilonRI, CD40L, IL-4, and IL-13, and can induce IgE synthesis in B cells.

1997 • 347 citations

Selective growth of human mast cells induced by Steel factor, IL-6, and prostaglandin E2 from cord blood mononuclear cells.

1996 • 324 citations

Activated mast cells produce interleukin 13.

1995 • 320 citations

Heterogeneity of human mast cells based on cytokine content.

1995 • 308 citations

Phenotypic Characterization of the Human Mast‐Cell Line HMC‐1

1994 • 259 citations

IL-4 enhances proliferation and mediator release in mature human mast cells

1999 • 248 citations

Interleukin 5 modifies histamine release and leukotriene generation by human basophils in response to diverse agonists.

1990 • 213 citations

Human mast cells produce the CD4+ T lymphocyte chemoattractant factor, IL-16.

1997 • 164 citations

Human mast cells produce IL-13 by high-affinity IgE receptor cross-linking: Enhanced IL-13 production by IL-4–primed human mast cells

1998 • 162 citations

Mast cells are an important cellular source of tumour necrosis factor α in human intestinal tissue

1999 • 160 citations

IgE-dependent expression of mRNA for IL-4 and IL-5 in human lung mast cells.

1995 • 149 citations

IL-3 and IL-5 prime normal human eosinophils to produce leukotriene C4 in response to soluble agonists.

1991 • 136 citations

Comparative cytokine gene expression: regulation and release by human mast cells

1998 • 123 citations

Human intestinal mast cells produce IL-5in vitro upon IgE receptor cross-linking andin vivo in the course of intestinal inflammatory disease

1999 • 83 citations

Tumor necrosis factor alpha and interleukin-1 beta mRNA expression in HMC-1 cells: differential regulation of gene product expression by recombinant interleukin-4.

1993 • 68 citations

Stem-cell factor, the kit ligand, induces direct degranulation of rat peritoneal mast cells in vitro and in vivo: dependence of the in vitro effect on period of culture and comparisons of stem-cell factor with other mast cell-activating agents.

1995 • 68 citations

Recombinant human IL-4 induces IgE and IgG synthesis by normal and atopic donor mononuclear cells. Similar dose response, time course, requirement for T cells, and effect of pokeweed mitogen.

1990 • 66 citations

Production of IL-5 and granulocyte-macrophage colony-stimulating factor by naive human mast cells activated by high-affinity IgE receptor ligation

1997 • 62 citations

Constitutive and Inducible Cytokine mRNA Expression in the Human Mast Cell Line HMC‐1

1995 • 57 citations

Functional properties of human intestinal mast cells cultured in a new culture system: enhancement of IgE receptor-dependent mediator release and response to stem cell factor.

1997 • 47 citations

IL-4 enhances IL-3 and IL-8 gene expression in a human leukemic mast cell line.

1995 • 41 citations

Human lung mast cells are enriched in the capacity to produce granulocyte-macrophage colony-stimulating factor in response to IgE-dependent stimulation

1998 • 40 citations

Stem Cell Factor–Dependent Survival, Proliferation and Enhanced Releasability of Purified Mature Mast Cells Isolated from Human Intestinal Tissue

1999 • 30 citations