Human intestinal mast cells produce IL-5in vitro upon IgE receptor cross-linking andin vivo in the course of intestinal inflammatory disease

Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5.

1996 • 1,227 citations

New Concepts about the Mast Cell

1993 • 1,009 citations

Recombinant human interleukin 5 is a selective activator of human eosinophil function.

1988 • 976 citations

Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines.

1994 • 850 citations

Eosinophilia

1998 • 802 citations

Human interleukin-5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: comparison and interaction with IL-1, IL-3, IL-6, and GMCSF

1989 • 676 citations

Release of both preformed and newly synthesized tumor necrosis factor alpha (TNF-alpha)/cachectin by mouse mast cells stimulated via the Fc epsilon RI. A mechanism for the sustained action of mast cell-derived TNF-alpha during IgE-dependent biological responses.

1991 • 369 citations

Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells.

1995 • 347 citations

Heterogeneity of human mast cells based on cytokine content.

1995 • 308 citations

Interleukin 5 synthesis by eosinophils: association with granules and immunoglobulin-dependent secretion.

1994 • 295 citations

c-kit ligand: a unique potentiator of mediator release by human lung mast cells.

1992 • 275 citations

Quantitative assessment of intestinal eosinophils and mast cells in inflammatory bowel disease

1996 • 261 citations

Interleukin 5 messenger RNA expression by eosinophils in the intestinal mucosa of patients with coeliac disease.

1992 • 244 citations

Interleukin 5 modifies histamine release and leukotriene generation by human basophils in response to diverse agonists.

1990 • 213 citations

High affinity human IgE receptor (Fc epsilon RI). Analysis of functional domains of the alpha-subunit with monoclonal antibodies

1991 • 197 citations

Heterogeneity of Mast Cells at Multiple Body Sites

1993 • 179 citations

Interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 in eosinophilic gastroenteritis

1996 • 163 citations

Monoclonal antibody YB5.B8 identifies the human c-kit protein product

1991 • 160 citations

Colonoscopic allergen provocation (COLAP): a new diagnostic approach for gastrointestinal food allergy.

1997 • 152 citations

IgE-dependent expression of mRNA for IL-4 and IL-5 in human lung mast cells.

1995 • 149 citations

IL-3 and IL-5 prime normal human eosinophils to produce leukotriene C4 in response to soluble agonists.

1991 • 136 citations

Activated eosinophils and interleukin 5 expression in early recurrence of Crohn's disease.

1995 • 113 citations

A nuclear factor of activated T cell-like transcription factor in mast cells is involved in IL-5 gene regulation after IgE plus antigen stimulation.

1995 • 99 citations

Assessment of the anti-c-kit monoclonal antibody YB5.B8 in affinity magnetic enrichment of human lung mast cells

1994 • 67 citations

Production of IL-5 and granulocyte-macrophage colony-stimulating factor by naive human mast cells activated by high-affinity IgE receptor ligation

1997 • 62 citations

Identification of Transcription Factor Binding Sites Important in the Regulation of the Human Interleukin-5 Gene

1997 • 53 citations

Characterization of the human interleukin‐5 gene promoter: involvement of octamer binding sites in the gene promoter activity

1995 • 50 citations

Two pathways can activate the interleukin-5 gene and induce binding to the conserved lymphokine element 0

1996 • 48 citations

Functional properties of human intestinal mast cells cultured in a new culture system: enhancement of IgE receptor-dependent mediator release and response to stem cell factor.

1997 • 47 citations

Effect of c-kit ligand, stem cell factor, on mediator release by human intestinal mast cells isolated from patients with inflammatory bowel disease and controls.

1996 • 39 citations

Transcription of the Murine Interleukin 5 Gene Is Regulated by Multiple Promoter Elements

1995 • 32 citations

Effects of the Transcription Inhibitor Actinomycin D on Postzygotic Development ofTetrahymena thermophilaConjugants

1996 • 19 citations

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