Posttranscriptional Regulation of Collagen α1(I) mRNA in Hepatic Stellate Cells

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Antibodies, a laboratory manual

1989 • 12,929 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

mRNA stability in mammalian cells

1995 • 1,258 citations

Hepatic lipocytes: the principal collagen-producing cells of normal rat liver.

1985 • 839 citations

The cap and poly(A) tail function synergistically to regulate mRNA translational efficiency.

1991 • 795 citations

Degradation of mRNA in eukaryotes

1995 • 648 citations

Transforming growth factor-beta increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts.

1987 • 467 citations

Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo.

1990 • 432 citations

Transforming growth factor beta increases mRNA for matrix proteins both in the presence and in the absence of changes in mRNA stability.

1988 • 420 citations

In vitro and in vivo association of transforming growth factor-beta 1 with hepatic fibrosis.

1989 • 420 citations

The contraction of hepatic stellate (Ito) cells stimulated with vasoactive substances

1993 • 391 citations

Purified Rat Liver Fat-Storing Cells in Culture Divide and Contain Collagen

1984 • 326 citations

Alcoholic liver injury in baboons: transformation of lipocytes to transitional cells.

1984 • 299 citations

Isolated hepatic lipocytes and kupffer cells from normal human liver: Morphological and functional characteristics in primary culture

1992 • 288 citations

In situ hybridization for procollagen types I, III and IV mRNA in normal and fibrotic rat liver: Evidence for predominant expression in nonparenchymal liver cells

1989 • 281 citations

Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein.

1992 • 281 citations

Alcoholic liver injury in baboons: Transformation of lipocytes to transitional cells

1984 • 275 citations

Activation-dependent contractility of rat hepatic lipocytes in culture and in vivo.

1993 • 264 citations

Perisinusoidal fat-storing cells are the main vitamin A storage sites in rat liver

1985 • 259 citations

Identification of two KH domain proteins in the alpha-globin mRNP stability complex.

1995 • 244 citations

Diversity of cytoplasmic functions for the 3′ untranslated region of eukaryotic transcripts

1995 • 241 citations

Cellular Sources of Collagen and Regulation of Collagen Production in Liver

1990 • 197 citations

Detection and Characterization of a 3′ Untranslated Region Ribonucleoprotein Complex Associated with Human α-Globin mRNA Stability

1995 • 194 citations

Procollagen expression by nonparenchymal rat liver cells in experimental biliary fibrosis

1990 • 192 citations

Regulatory elements in the first intron contribute to transcriptional control of the human alpha 1(I) collagen gene.

1987 • 191 citations

Ito–Cell Gene Expression and Collagen Regulation

1990 • 190 citations

Tumor necrosis factor-alpha and interferon-gamma suppress the activation of human type I collagen gene expression by transforming growth factor-beta 1. Evidence for two distinct mechanisms of inhibition at the transcriptional and posttranscriptional levels.

1990 • 178 citations

In vitro differentiation of fat-storing cells parallels marked increase of collagen synthesis and secretion

1989 • 175 citations

Cell cycle regulation of mouse H3 histone mRNA metabolism.

1984 • 165 citations

Synthesis and degradation of type I procollagen mRNAs in cultured human skin fibroblasts and the effect of cortisol.

1985 • 148 citations

Erythroid cell-specific determinants of alpha-globin mRNA stability.

1994 • 145 citations

Transforming growth factor-beta 1 and type I procollagen transcripts during regeneration and early fibrosis of rat liver.

1990 • 144 citations

DNA sequences in the first intron of the human pro-alpha 1(I) collagen gene enhance transcription.

1987 • 135 citations

Transcriptional switch from albumin to .alpha.-fetoprotein and changes in transcription of other genes during carbon tetrachloride-induced liver regeneration

1986 • 135 citations

Transcription factors nuclear factor I and Sp1 interact with the murine collagen alpha 1 (I) promoter.

1991 • 131 citations

Functional analysis of cis-acting DNA sequences controlling transcription of the human type I collagen genes.

1990 • 127 citations

Regulation of expression of the type I collagen genes

1993 • 121 citations

Regulatory elements in the 5'-flanking region and the first intron contribute to transcriptional control of the mouse alpha 1 type I collagen gene.

1989 • 121 citations

Characterization of desmin-positive rat liver sinusoidal cells

1987 • 111 citations

Sp1 binding activity increases in activated Ito cells

1995 • 104 citations

Tissue Specificity of Type I Collagen Gene Expression Is Determined at Both Transcriptional and Post-Transcriptional Levels

1984 • 103 citations

Transcriptional mechanisms of type I collagen gene expression are differentially regulated by interleukin-1 beta, tumor necrosis factor alpha, and transforming growth factor beta in Ito cells.

1992 • 103 citations

An upstream regulatory region mediates high-level, tissue-specific expression of the human alpha 1(I) collagen gene in transgenic mice.

1991 • 83 citations

A conserved nucleotide sequence, coding for a segment of the C-propeptkle, is found at the same location in different collagen genes

1983 • 81 citations

Common mechanisms for the control of eukaryotic transcriptional elongation

1993 • 71 citations

NF-I/Sp1 Switch Elements Regulate Collagen α1(I) Gene Expression

1992 • 70 citations

Analysis of the collagen α(I) promoter

1989 • 64 citations

Differential regulation of transcription and transcript stability of pro-α 1(I) collagen and fibronectin in activated fibroblasts derived from patients with systemic scleroderma

1996 • 63 citations

Regulation of collagen I gene expression by ras.

1992 • 63 citations

[27] Photoaffinity cross-linking methods for studying RNA-protein interactions

1989 • 55 citations

Long-Range RNA Interaction of Two Sequence Elements Required for Endonucleolytic Cleavage of Human Insulin-Like Growth Factor II mRNAs

1995 • 55 citations

Stimulation of the collagen α1(I) endogenous gene and transgene in carbon tetrachloride–induced hepatic fibrosis

1993 • 53 citations

The use of caprylic acid for the extraction of the immunoglobulin fraction from egg yolk of chickens immunised with ovine α-lactalbumin

1994 • 52 citations

Two different cis-acting regulatory regions direct cell-specific transcription of the collagen alpha 1(I) gene in hepatic stellate cells and in skin and tendon fibroblasts.

1995 • 52 citations

Changes in albumin, α-fetoprotein and collagen gene transcription in ccl4-induced hepatic fibrosis

1988 • 50 citations

Acetalde hyde‐Induced Stimulation of Collagen Synthesis and Gene Expression Is Dependent on Conditions of Cell Culture: Studies with Rat Lipocytes and Fibroblasts

1994 • 49 citations

Collagen Production by Rat Liver Fat-Storing Cells in Primary Culture

1986 • 46 citations

DNA methylation represses the murine alpha 1(I) collagen promoter by an indirect mechanism.

1994 • 45 citations

Binding of Upstream Stimulatory Factor to an E-box in the 3′-Flanking Region Stimulates α1(I) Collagen Gene Transcription

1997 • 45 citations

Regulation of the alpha 1(I) collagen promoter in vascular smooth muscle cells. Comparison with other alpha 1(I) collagen-producing cells in transgenic animals and cultured cells.

1994 • 42 citations

Tissue-specific Expression of the Gene for Type I Procollagen (COL1A1) in Transgenic Mice

1995 • 35 citations

The Effects of Hepatic Fibrosis on Ito Cell Gene Expression

1992 • 34 citations

Two mRNAs of mouse pro αl(D collagen gene differ in the size of the 3′-untranslated region

1988 • 31 citations

Pathogenesis of Hepatic Fibrosis and the Role of Cytokines

1992 • 25 citations

Human-Mouse Interspecies Collagen I Heterotrimer Is Functional during Embryonic Development of Mov13 Mutant Mouse Embryos

1990 • 23 citations

Isolation of a murine gene encoding a nucleic acid-binding protein with homology to hnRNP K

1993 • 23 citations

A fibroblast protein binds the 3′-untranslated region of pro-α1(I) collagen mRNA

1993 • 23 citations

Effect of the 3′-untranslated region on the expression levels and rnRNA stability of α1(I) collagen gene

1995 • 22 citations

Nuclear and cytoplasmic α1(I) collagen mRNA‐binding proteins

1994 • 14 citations

DNA Methylation Represses the Murine αl (I) Collagen Promoter by an Indirect Mechanism

1994 • 9 citations