The Aurora kinases: role in cell transformation and tumorigenesis.

A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

1997 • 3,167 citations

Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

2001 • 2,746 citations

Regulation of chromatin structure by site-specific histone H3 methyltransferases

2000 • 2,709 citations

Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation

1997 • 1,814 citations

Mitotic kinases as regulators of cell division and its checkpoints

2001 • 1,503 citations

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

1998 • 1,288 citations

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

1998 • 1,210 citations

Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

1995 • 940 citations

Mitotic Phosphorylation of Histone H3 Is Governed by Ipl1/aurora Kinase and Glc7/PP1 Phosphatase in Budding Yeast and Nematodes

2000 • 847 citations

In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation of lamins by cdc2 kinase

1990 • 783 citations

Evidence that the Ipl1-Sli15 (Aurora Kinase-INCENP) Complex Promotes Chromosome Bi-orientation by Altering Kinetochore-Spindle Pole Connections

2002 • 725 citations

Phosphorylation of Histone H3 Is Required for Proper Chromosome Condensation and Segregation

1999 • 701 citations

Human TPX2 is required for targeting Aurora-A kinase to the spindle

2002 • 563 citations

Purification and Molecular Cloning of Plx1, a Cdc25-Regulatory Kinase from Xenopus Egg Extracts

1996 • 506 citations

Functional Analysis of Kinetochore Assembly in Caenorhabditis elegans

2001 • 440 citations

The inner centromere protein (INCENP) antigens: movement from inner centromere to midbody during mitosis.

1987 • 407 citations

A 17-kD centromere protein (CENP-A) copurifies with nucleosome core particles and with histones

1987 • 401 citations

AIM-1: a mammalian midbody-associated protein required for cytokinesis

1998 • 392 citations

Early disruption of centromeric chromatin organization in centromere protein A (Cenpa) null mice

2000 • 388 citations

Identification of differentially expressed genes in pancreatic cancer cells using cDNA microarray.

2002 • 373 citations

Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells.

1998 • 324 citations

Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules

2002 • 324 citations

Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases

1999 • 318 citations

Aurora B Kinase Exists in a Complex with Survivin and INCENP and Its Kinase Activity Is Stimulated by Survivin Binding and Phosphorylation

2002 • 318 citations

CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis

2001 • 317 citations

Proteolysis and the cell cycle: with this RING I do thee destroy

2000 • 308 citations

INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow

2000 • 307 citations

Inhibition of Aurora B Kinase Blocks Chromosome Segregation, Overrides the Spindle Checkpoint, and Perturbs Microtubule Dynamics in Mitosis

2002 • 307 citations

Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast.

1999 • 306 citations

Amplification/Overexpression of a Mitotic Kinase Gene in Human Bladder Cancer

2002 • 303 citations

AIR-2: An Aurora/Ipl1-related Protein Kinase Associated with Chromosomes and Midbody Microtubules Is Required for Polar Body Extrusion and Cytokinesis in Caenorhabditis elegans Embryos

1998 • 303 citations

Opposing motor activities are required for the organization of the mammalian mitotic spindle pole.

1996 • 301 citations

Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit

2002 • 295 citations

Increased mitotic phosphorylation of histone H3 attributable to AIM-1/Aurora-B overexpression contributes to chromosome number instability.

2002 • 288 citations

The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation

2000 • 281 citations

Phosphorylation of the Carboxyl Terminus of Inner Centromere Protein (INCENP) by the Aurora B Kinase Stimulates Aurora B Kinase Activity

2002 • 262 citations

The Survivin-like C. elegans BIR-1 Protein Acts with the Aurora-like Kinase AIR-2 to Affect Chromosomes and the Spindle Midzone

2000 • 252 citations

Cell Cycle-dependent Expression and Centrosome Localization of a Third Human Aurora/Ipl1-related Protein Kinase, AIK3

1999 • 249 citations

The Aurora B Kinase AIR-2 Regulates Kinetochores during Mitosis and Is Required for Separation of Homologous Chromosomes during Meiosis

2002 • 235 citations

Association of centrosomal kinaseSTK15/BTAK mRNA expression with chromosomal instability in human breast cancers

2001 • 231 citations

Identification of phosphorylated residues that affect the activity of the mitotic kinase Aurora-A

2002 • 223 citations

Mitotic Spindle Poles are Organized by Structural and Motor Proteins in Addition to Centrosomes

1997 • 220 citations

INCENP Centromere and Spindle Targeting: Identification of Essential Conserved Motifs and Involvement of Heterochromatin Protein HP1

1998 • 208 citations

A mammalian homologue of Drosophila heterochromatin protein 1 (HP1) is a component of constitutive heterochromatin

1994 • 196 citations

Crystal Structure of Aurora-2, an Oncogenic Serine/Threonine Kinase

2002 • 191 citations

Interaction and Feedback Regulation between STK15/BTAK/Aurora-A Kinase and Protein Phosphatase 1 through Mitotic Cell Division Cycle

2001 • 189 citations

The Kinase Activity of Aurora B Is Required for Kinetochore-Microtubule Interactions during Mitosis

2002 • 188 citations

Centrosome amplification and overexpression of aurora A are early events in rat mammary carcinogenesis.

2002 • 182 citations

APC/Fizzy‐Related targets Aurora‐A kinase for proteolysis

2002 • 162 citations

Supernumerary centrosomes and cancer: Boveri's hypothesis resurrected

1998 • 156 citations

A Dominant Mutant of Inner Centromere Protein (INCENP), a Chromosomal Protein, Disrupts Prometaphase Congression and Cytokinesis

1998 • 151 citations

The kinase Eg2 is a component of the Xenopus oocyte progesterone-activated signaling pathway

1998 • 147 citations

Phosphorylation by p34cdc2 Protein Kinase Regulates Binding of the Kinesin-related Motor HsEg5 to the Dynactin Subunit p150Glued

1997 • 145 citations

ISWI Remodeling Complexes inXenopusEgg Extracts: Identification as Major Chromosomal Components that Are Regulated by INCENP-aurora B

2002 • 140 citations

Xe-p9, a Xenopus Suc1/Cks protein, is essential for the Cdc2-dependent phosphorylation of the anaphase- promoting complex at mitosis

1998 • 139 citations

Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells

2001 • 123 citations

Proteolytic ratchets that control progression through mitosis

1998 • 122 citations

Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function

2002 • 111 citations

Nonperiodic Activity of the Human Anaphase-Promoting Complex–Cdh1 Ubiquitin Ligase Results in Continuous DNA Synthesis Uncoupled from Mitosis

2000 • 101 citations

Dynamic Changes in Nuclear Architecture during Mitosis: On the Role of Protein Phosphorylation in Spindle Assembly and Chromosome Segregation

1996 • 94 citations

The D‐Box‐activating domain (DAD) is a new proteolysis signal that stimulates the silent D‐Box sequence of Aurora‐A

2002 • 89 citations

Dynamic association of a tumor amplified kinase, Aurora‐A, with the centrosome and mitotic spindle

2003 • 88 citations

Protein kinases in control of the centrosome cycle

1999 • 77 citations

Chromosome Dynamics: New Light on Aurora B Kinase Function

2002 • 76 citations

Balanced regulation of microtubule dynamics during the cell cycle: a contemporary view

1999 • 73 citations

Motoring to the Finish: Kinesin and Dynein Work Together to Orient the Yeast Mitotic Spindle

1997 • 72 citations

Cdc20 associates with the kinase aurora2/Aik

1999 • 68 citations

Genomic Organization, Expression, and Chromosome Localization of a Third Aurora-Related Kinase Gene,Aie1

2000 • 68 citations

Human autoimmune sera recognize a conserved 26 kD protein associated with mammalian heterochromatin that is homologous to heterochromatin protein 1 ofDrosophila

1994 • 54 citations

The non-catalytic domain of the Xenopus laevis auroraA kinase localises the protein to the centrosome

2001 • 51 citations

Aurora-A Kinase Interacting Protein (AIP), a Novel Negative Regulator of Human Aurora-A Kinase

2002 • 44 citations

Cell cycle: Checkpoint proteins and kinetochores

1997 • 44 citations

Identification of Aurora Kinases as RasGAP Src Homology 3 Domain-binding Proteins

2002 • 42 citations

The INCENPs: Structural and Functional Analysis of a Family of Chromosome Passenger Proteins

1993 • 16 citations

Mutational Analysis of the Phosphorylation Sites of the Aie1 (Aurora-C) Kinasein Vitro

2002 • 13 citations