The evolution of mutation rates: separating causes from consequences

The genetical theory of natural selection

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DNA Repair and Mutagenesis

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The hitch-hiking effect of a favourable gene

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THE MAJOR TRANSITIONS OF EVOLUTION

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The Evolution of Sex

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Enzyme structure and mechanism

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Enzyme structure and mechanism

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The hitch-hiking effect of a favourable gene

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The Major Transitions in Evolution

1997 • 2,625 citations

DNA repair and mutagenesis

1996 • 2,289 citations

Rates of Spontaneous Mutation

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How clonal are bacteria?

1993 • 1,804 citations

A constant rate of spontaneous mutation in DNA-based microbes.

1991 • 1,194 citations

Mutation rates among RNA viruses

1999 • 1,122 citations

Evolution of high mutation rates in experimental populations of E. coli

1997 • 909 citations

High Mutation Frequencies Among Escherichia coli and Salmonella Pathogens

1996 • 836 citations

The fate of competing beneficial mutations in an asexual population

1998 • 797 citations

Why Sex and Recombination?

1998 • 794 citations

Untitled

1998 • 790 citations

Adaptive evolution of highly mutable loci in pathogenic bacteria

1994 • 764 citations

Role of mutator alleles in adaptive evolution

1997 • 697 citations

The Mutational Meltdown in Asexual Populations

1993 • 630 citations

Evidence for the Evolution of Bdelloid Rotifers Without Sexual Reproduction or Genetic Exchange

2000 • 626 citations

A pluralist approach to sex and recombination

1999 • 568 citations

MUTATION LOAD AND THE SURVIVAL OF SMALL POPULATIONS

1990 • 459 citations

The mutation rate and cancer

1996 • 459 citations

Significance of multiple mutations in cancer

2000 • 441 citations

High genomic deleterious mutation rates in hominids

1999 • 405 citations

Linkage and the limits to natural selection.

1995 • 397 citations

Diminishing Returns from Mutation Supply Rate in Asexual Populations

1999 • 384 citations

A ruby in the rubbish: beneficial mutations, deleterious mutations and the evolution of sex.

1994 • 350 citations

Proliferation of mutators in A cell population

1997 • 342 citations

On the evolutionary adjustment of spontaneous mutation rates

1967 • 338 citations

MULLER'S RATCHET AND MUTATIONAL MELTDOWNS

1993 • 326 citations

SPONTANEOUS MUTATORS IN BACTERIA: Insights into Pathways of Mutagenesis and Repair

1996 • 254 citations

COMPETITION BETWEEN HIGH AND LOW MUTATING STRAINS OF ESCHERICHIA COLI

1983 • 246 citations

Mutators, Population Size, Adaptive Landscape and the Adaptation of Asexual Populations of Bacteria

1999 • 245 citations

The Rate of Adaptation in Asexuals

2000 • 233 citations

Natural Selection and Mutability

1970 • 218 citations

Distribution of chromosome length variation in natural isolates of Escherichia coli

1998 • 213 citations

Spontaneous Mutation: Genetic Control of Mutation Rates in Bacteriophage T4

1969 • 206 citations

The Consequences of Growth of a Mutator Strain of Escherichia coli as Measured by Loss of Function Among Multiple Gene Targets and Loss of Fitness

2000 • 196 citations

Escherichia coli mutator genes

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Evolutionarily stable mutation rate in a periodically changing environment.

1989 • 182 citations

Studies on the biochemical basis of spontaneous mutation

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Essays on Evolution. I. On the Effects of Selection on Mutation Rate

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MUTATION AND ADAPTATION: The Directed Mutation Controversy in Evolutionary Perspective

1995 • 163 citations

Towards a theory of the evolution of modifier genes

1974 • 153 citations

Evidence for the Adaptive Evolution of Mutation Rates

2000 • 152 citations

Evidence for a selectively favourable reduction in the mutation rate of the X chromosome

1997 • 145 citations

SELECTION FOR HIGH MUTATION RATES IN CHEMOSTATS

1974 • 142 citations

The evolution of mutation rates.

1973 • 134 citations

SPONTANEOUS MUTATION

1991 • 131 citations

Accuracy in Molecular Processes

1986 • 123 citations

SELECTIVE ALLELE LOSS IN MIXED INFECTIONS WITH T4 BACTERIOPHAGE

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Population Evolution on a Multiplicative Single-Peak Fitness Landscape

1996 • 109 citations

The approach to mutation–selection balance in an infinite asexual population, and the evolution of mutation rates

1999 • 108 citations

Modifiers of mutation rate: A general reduction principle

1986 • 108 citations

Beneficial Mutations, Hitchhiking and the Evolution of Mutation Rates in Sexual Populations

1999 • 106 citations

Modifiers of mutation-selection balance: general approach and the evolution of mutation rates

1995 • 103 citations

Selection against hypermutability in Escherichia coli during long term evolution

1984 • 90 citations

Recombination and Population Structure in Escherichia coli

1997 • 90 citations

Fitness of an Escherichia coli Mutator Gene

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The frequency of mutators in populations of Escherichia coli

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Incidence of mutator strains in Escherichia coli and coliforms in nature

1981 • 87 citations

Evolutionarily Stable Mutation Rates

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OBSERVATIONS ON TWO TYPES OF GENETIC INSTABILITY IN ESCHERICHIA COLI

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General Antimutators are Improbable

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MUTATION MODIFICATION IN A RANDOM ENVIRONMENT

1981 • 61 citations

The Dynamics of Infinitesimally Rare Alleles, Applied to the Evolution of Mutation Rates and the Expression of Deleterious Mutations

1999 • 52 citations

Antimutator Mutants in Bacteriophage T4 and Escherichia coli

1998 • 48 citations

Adaptation of Drosophila melanogaster populations to high mutation pressure: evolutionary adjustment of mutation rates.

1987 • 42 citations

Competition between isogenic mutS and mut + populations of Escherichia coli K12 in continuously growing cultures

1984 • 41 citations

Modifiers of mutation rate: Evolutionary optimum with complete selfing

1983 • 37 citations

Population changes in continuously growing mutator cultures of Escherichia coli.

1973 • 36 citations

Is there a unique ribosome phenotype for naturally occurring Escherichia coli?

1991 • 36 citations

MUTATOR GENES AND SELECTION FOR THE MUTATION RATE IN BACTERIA

1975 • 33 citations

Contingency Loci, Mutator Alleles, and Their Interactions: Synergistic Strategies for Microbial Evolution and Adaptation in Pathogenesis^a

1999 • 31 citations

Clone-selection and optimal rates of mutation

1973 • 30 citations

Isolation and characterization of Escherichia coli antimutators

1985 • 27 citations

Accuracy in molecular processes : its control and relevance to living systems

1986 • 26 citations

When Being Hyper Keeps You Fit

2000 • 16 citations