SPONTANEOUS MUTATORS IN BACTERIA: Insights into Pathways of Mutagenesis and Repair

Experiments in molecular genetics

1972 • 28,260 citations

The Clonal Evolution of Tumor Cell Populations

1976 • 6,310 citations

DNA Repair and Mutagenesis

2006 • 4,725 citations

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1993 • 2,884 citations

Prooxidant States and Tumor Promotion

1985 • 2,541 citations

A short course in bacterial genetics : a laboratory manual and handbook for Escherichia coli and related bacteria

1992 • 2,517 citations

DNA repair and mutagenesis

1996 • 2,289 citations

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

1993 • 2,282 citations

Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

1991 • 2,172 citations

Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer

1994 • 2,071 citations

Mutation of a mutL Homolog in Hereditary Colon Cancer

1994 • 1,834 citations

Mutator phenotype may be required for multistage carcinogenesis.

1991 • 1,327 citations

Molecular basis of base substitution hotspots in Escherichia coli

1978 • 1,185 citations

Oxidative stress responses in Escherichia coli and Salmonella typhimurium

1991 • 981 citations

MECHANISMS AND BIOLOGICAL EFFECTS OF MISMATCH REPAIR

1991 • 876 citations

MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis

1992 • 875 citations

Mutagenic deamination of cytosine residues in DNA

1980 • 761 citations

FIDELITY MECHANISMS IN DNA REPLICATION

1991 • 709 citations

The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine)

1992 • 688 citations

Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome

1990 • 687 citations

8-oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity.

1991 • 678 citations

Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA.

1992 • 590 citations

Microsatellite instability: marker of a mutator phenotype in cancer.

1994 • 552 citations

The experimental study of tumor progression: a review.

1954 • 522 citations

Fidelity of DNA Synthesis

1982 • 516 citations

A set of lacZ mutations in Escherichia coli that allow rapid detection of each of the six base substitutions.

1989 • 451 citations

Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis.

1993 • 437 citations

Errors and alternatives in reading the universal genetic code

1989 • 407 citations

REGULATION OF BACTERIAL OXIDATIVE STRESS GENES

1991 • 377 citations

The mutY gene: a mutator locus in Escherichia coli that generates G.C----T.A transversions.

1988 • 343 citations

BACTERIAL MUTATOR GENES AND THE CONTROL OF SPONTANEOUS MUTATION

1976 • 342 citations

Oxygen-dependent mutagenesis in Escherichia coli lacking superoxide dismutase.

1986 • 314 citations

Repair tracts in mismatched DNA heteroduplexes.

1976 • 300 citations

Methyl-directed DNA Mismatch Correction

1989 • 297 citations

Oxidants Are a Major Contributor to Aginga

1992 • 296 citations

NMR structural studies of the ionizing radiation adduct 7-hydro-8-oxodeoxyguanosine (8-oxo-7H-dG) opposite deoxyadenosine in a DNA duplex. 8-Oxo-7H-dG(syn).cntdot.dA(anti) alignment at lesion site

1991 • 295 citations

Spectra of spontaneous mutations in Escherichia coli strains defective in mismatch correction: the nature of in vivo DNA replication errors.

1987 • 291 citations

Formamidopyrimidine-DNA glycosylase of Escherichia coli: cloning and sequencing of the fpg structural gene and overproduction of the protein.

1987 • 285 citations

The unusual mutagenic specificity of an E. Coli mutator gene.

1966 • 271 citations

Mutagenesis and carcinogenesis: Endogenous and exogenous factors

1989 • 266 citations

Release of 7-methylguanine residues whose imidazole rings have been opened from damaged DNA by a DNA glycosylase from Escherichla coli

1979 • 257 citations

MISMATCH REPAIR IN ESCHERICHIA COLI

1986 • 253 citations

A separate editing exonuclease for DNA replication: the epsilon subunit of Escherichia coli DNA polymerase III holoenzyme.

1984 • 246 citations

A Factor (or Mutator Gene) Influencing Mutation Rates in Escherichia Coli

1954 • 229 citations

Escherichia coli mutY gene encodes an adenine glycosylase active on G-A mispairs.

1989 • 225 citations

Spontaneous mutagenesis and oxidative damage to DNA in Salmonella typhimurium.

1987 • 222 citations

Identification of the epsilon-subunit of Escherichia coli DNA polymerase III holoenzyme as the dnaQ gene product: a fidelity subunit for DNA replication.

1983 • 212 citations

A set of lacZ mutations in Escherichia coli that allow rapid detection of specific frameshift mutations.

1990 • 211 citations

MutM, a protein that prevents G C→T A transversions, is formamidopyrimidine-DNA glycosylase

1991 • 210 citations

Mechanisms of mutagenesis in the Escherichia coli mutator mutD5: role of DNA mismatch repair.

1988 • 203 citations

Conditional Mutator Gene in Escherichia coli : Isolation, Mapping, and Effector Studies

1974 • 201 citations

Mutational specificity of a conditional Escherichia coli mutator, mutD5

1974 • 200 citations

Genetic toxicology of oxygen

1989 • 198 citations

The Repairability of Oxidative Free Radical Mediated Damage to DNA: A Review

1988 • 196 citations

Reverse chemical mutagenesis: identification of the mutagenic lesions resulting from reactive oxygen species-mediated damage to DNA.

1994 • 189 citations

mutM, a second mutator locus in Escherichia coli that generates G.C----T.A transversions

1988 • 180 citations

Mutator strains of Escherichia coli, mutD and dnaQ, with defective exonucleolytic editing by DNA polymerase III holoenzyme.

1983 • 174 citations

Mismatch repair in heteroduplex DNA.

1975 • 165 citations

Mutants in the Exo I motif of Escherichia coli dnaQ: defective proofreading and inviability due to error catastrophe.

1996 • 163 citations

Repair of DNA containing the oxidatively-damaged base, 8-oxoguanine

1993 • 161 citations

Escherichia coli mutants uvr D and uvr E deficient in gene conversion of λ-heteroduplexes

1975 • 154 citations

Bidirectional excision in methyl-directed mismatch repair

1993 • 153 citations

Transient mutators: a semiquantitative analysis of the influence of translation and transcription errors on mutation rates.

1991 • 153 citations

Escherichia coli mutY gene product is required for specific A-G----C.G mismatch correction.

1988 • 152 citations

An endonuclease activity of Escherichia coli that specifically removes 8-hydroxyguanine residues from DNA

1991 • 149 citations

The extreme mutator effect of Escherichia coli mutD5 results from saturation of mismatch repair by excessive DNA replication errors.

1989 • 149 citations

The vsr gene product of E. coli K-12 is a strand- and sequence-specific DNA mismatch endonuclease

1991 • 135 citations

tRNA, SUPPRESSION, AND THE CODE

1985 • 134 citations

SPONTANEOUS MUTATION

1991 • 131 citations

Bromouracil mutagenesis and mismatch repair in mutator strains of Escherichia coli

1978 • 121 citations

On the Molecular Basis of High Negative Interference

1974 • 103 citations

Spontaneous mutagenesis: Experimental, genetic and other factors

1992 • 103 citations

Specificity of the mutator caused by deletion of the yeast structural gene (APN1) for the major apurinic endonuclease.

1994 • 98 citations

Influence of neighboring bases on DNA polymerase insertion and proofreading fidelity.

1985 • 98 citations

The suicidal DNA repalr methyltransferases of microbes

1992 • 94 citations

Mutants of Escherichia coli with increased fidelity of DNA replication.

1993 • 89 citations

Spontaneous mutation at a 5-methylcytosine hotspot is prevented by very short patch (VSP) mismatch repair.

1991 • 89 citations

Spontaneous mutagenesis in Escherichia coli strains lacking 6-methyladenine residues in their DNA an altered mutational spectrum in dam− mutants

1979 • 88 citations

Mismatch repair of deaminated 5-methyl-cytosine

1987 • 88 citations

Incidence of mutator strains in Escherichia coli and coliforms in nature

1981 • 87 citations

DNA alkylation repair limits spontaneous base substitution mutations in Escherichia coli

1994 • 84 citations

MUTATOR FACTOR IN SALMONELLA TYPHIMURIUM

1960 • 81 citations

Structure of Escherichia coli K-12 miaA and characterization of the mutator phenotype caused by miaA insertion mutations

1991 • 78 citations

The lacI Gene: Its Role in lac Operon Control and Its Use as a Genetic System

1980 • 74 citations

Effects of Escherichia coli dnaE antimutator alleles in a proofreading-deficient mutD5 strain

1995 • 70 citations

DOMINANT MUTATORS IN ESCHERICHIA COLI

1982 • 65 citations

OBSERVATIONS ON TWO TYPES OF GENETIC INSTABILITY IN ESCHERICHIA COLI

1960 • 64 citations

Mutator tRNAs are encoded by the Escherichia coli mutator genes mutA and mutC: a novel pathway for mutagenesis.

1996 • 62 citations

Analysis of spontaneous base substitutions generated in mismatch-repair-deficient strains of Escherichia coli

1986 • 61 citations

Antimutator mutations in the alpha subunit of Escherichia coli DNA polymerase III: identification of the responsible mutations and alignment with other DNA polymerases.

1993 • 56 citations

Escherichia coli mutator mutD5 is defective in the mutHLS pathway of DNA mismatch repair.

1989 • 53 citations

Isolation, Characterization, and Genetic Analysis of Mutator Genes in Escherichia coli B and K-12

1970 • 51 citations

Isolation and characterization of mutator strains of Escherichia coli K-12

1975 • 50 citations

Saturation of mismatch repair in the mutD5 mutator strain of Escherichia coli

1989 • 46 citations

Excision of the imidazole ring-opened form of N-2-aminofluorene-C(8)-guanine adduct in poly(dG-dC) by Escherichia coli fonnamidopyrimidine-DNA glycosylase

1989 • 42 citations

Isolation of an Escherichia coli K-12 dnaE mutation as a mutator

1978 • 42 citations

mutA and mutC: two mutator loci in Escherichia coli that stimulate transversions.

1990 • 42 citations

Very short patch repair of T:G mismatches in vivo: importance of context and accessory proteins

1995 • 39 citations

SPONTANEOUS MUTABILITY IN DROSOPHILA

1941 • 38 citations

Genetic consequences of transfection with heteroduplex bacteriophage λ DNA

1975 • 34 citations

Structure and coding properties of a dominant Escherichia coli mutator gene, mutD.

1983 • 32 citations

Selection of a Mutant ofEscherichia coliWhich Has High Mutation Rates

1968 • 24 citations

Gamma irradiation of cytosine in an aerated aqueous solution. I. Identification of radiolysis products of cytosine resulting from the deamination pathway.

1974 • 15 citations

Identification of Radiolysis Products of Cytosine Resulting from the Deamination Pathway

1974 • 15 citations

The high mutator activity of the dnaQ49 allele of Escherichia coli is medium-dependent and results from both defective 3′→5′ proofreading and methyl-directed mismatch repair

1993 • 14 citations