Attenuation of DNA-dependent protein kinase activity and its catalytic subunit by the herpes simplex virus type 1 transactivator ICP0

The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen

1993 • 1,219 citations

Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation

1995 • 862 citations

DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

1995 • 742 citations

Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination

1994 • 637 citations

DNA-Dependent Kinase (p350) as a Candidate Gene for the Murine SCID Defect

1995 • 610 citations

Absence of p350 Subunit of DNA-Activated Protein Kinase from a Radiosensitive Human Cell Line

1995 • 530 citations

Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen.

1990 • 415 citations

Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency

1989 • 372 citations

Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II.

1992 • 367 citations

Restoration of X-ray Resistance and V(D)J Recombination in Mutant Cells by Ku cDNA

1994 • 351 citations

DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair.

1995 • 342 citations

A human RNA polymerase II complex associated with SRB and DNA-repair proteins

1996 • 341 citations

Deletion mutants in the gene encoding the herpes simplex virus type 1 immediate-early protein ICP0 exhibit impaired growth in cell culture

1987 • 333 citations

During latency, herpes simplex virus type 1 DNA is associated with nucleosomes in a chromatin structure

1989 • 301 citations

The DNA-dependent Protein Kinase Is Inactivated by Autophosphorylation of the Catalytic Subunit

1996 • 287 citations

Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells.

1995 • 286 citations

A DNA-activated protein kinase from HeLa cell nuclei.

1990 • 285 citations

The nuclear location of PML, a cellular member of the C3HC4 zinc-binding domain protein family, is rearranged during herpes simplex virus infection by the C3HC4 viral protein ICP0

1994 • 281 citations

Alternative Mechanisms for Activation of Human Immunodeficiency Virus Enhancer in T Cells

1988 • 265 citations

Herpes simplex virus type 1 ICP0 regulates expression of immediate-early, early, and late genes in productively infected cells

1992 • 257 citations

Genetic evidence for two distinct transactivation functions of the herpes simplex virus alpha protein ICP27

1990 • 247 citations

Menage á trois: Double strand break repair, V(D)J recombination and DNA-PK

1995 • 245 citations

Absence of a Ku-like DNA end binding activity in the xrs double-strand DNA repair-deficient mutant.

1994 • 238 citations

Herpes simplex virus type 1 ICP0 plays a critical role in the de novo synthesis of infectious virus following transfection of viral DNA

1989 • 237 citations

The herpes simplex virus type 1 regulatory protein ICP0 enhances virus replication during acute infection and reactivation from latency

1993 • 233 citations

Involvement of the Ku autoantigen in the cellular response to DNA double-strand breaks.

1994 • 215 citations

Sequence-specific DNA binding by Ku autoantigen and its effects on transcription

1996 • 211 citations

The nuclear serine/threonine protein kinase DNA-PK.

1992 • 192 citations

Herpes simplex virus immediate-early protein ICP22 is required for viral modification of host RNA polymerase II and establishment of the normal viral transcription program

1995 • 167 citations

A DNA end-binding factor involved in double-strand break repair and V(D)J recombination.

1994 • 164 citations

RNA polymerase II is aberrantly phosphorylated and localized to viral replication compartments following herpes simplex virus infection

1994 • 152 citations

Human Cells Contain a DNA-Activated Protein Kinase that Phosphorylates Simian Virus 40 T Antigen, Mouse p53, and the Human Ku Autoantigen

1990 • 144 citations

Complementation of the ionizing radiation sensitivity, DNA end binding, and V(D)J recombination defects of double-strand break repair mutants by the p86 Ku autoantigen.

1995 • 138 citations

Herpes simplex virus type 1 immediate-early protein Vmw110 reactivates latent herpes simplex virus type 2 in an in vitro latency system

1989 • 132 citations

DNA-dependent protein kinase: a potent inhibitor of transcription by RNA polymerase I.

1995 • 121 citations

Herpesvirus Transcription and Its Regulation

1991 • 118 citations

Herpes simplex viruses with mutations in the gene encoding ICP0 are defective in gene expression

1992 • 115 citations

A cellular function can enhance gene expression and plating efficiency of a mutant defective in the gene for ICP0, a transactivating protein of herpes simplex virus type 1

1991 • 114 citations

A DNA-Activated Protein Kinase from HeLa Cell Nuclei

1990 • 109 citations

Repair and Recombination: How to make ends meet

1995 • 101 citations

Point mutations in the herpes simplex virus type 1 Vmw110 RING finger helix affect activation of gene expression, viral growth, and interaction with PML-containing nuclear structures

1995 • 87 citations

Separation of Sequence Requirements for HSV-1 Vmw110 Multimerisation and Interaction with a 135-kDa Cellular Protein

1995 • 84 citations

Purification and characterization of the double-stranded DNA-activated protein kinase, DNA-PK, from human placenta

1996 • 81 citations

Herpes Simplex Virus Genes Involved in Latency in vitro

1987 • 78 citations

Chromosomal organization of the herpes simplex virus genome during acute infection of the mouse central nervous system

1986 • 73 citations

Stimulation of the DNA-dependent Protein Kinase by RNA Polymerase II Transcriptional Activator Proteins

1995 • 66 citations

Physical interaction between the herpes simplex virus type 1 immediate-early regulatory proteins ICP0 and ICP4

1994 • 64 citations

DNA-dependent protein kinase specifically represses promoter-directed transcription initiation by RNA polymerase I.

1995 • 63 citations

High level expression and purification of herpes simplex virus type 1 immediate early polypeptide Vmw110

1991 • 61 citations

Properties of herpesvirus-induced “immediate early” polypeptides

1980 • 59 citations

Functional and genetic analysis of the role of Vmw110 in herpes simplex virus replication

1991 • 59 citations

The RR1 gene of herpes simplex virus type 1 is uniquely trans activated by ICP0 during infection

1993 • 58 citations

Absence of autoantigen Ku in mature human neutrophils and human promyelocytic leukemia line (HL-60) cells and lymphocytes undergoing apoptosis.

1995 • 57 citations

Lack of correlation between DNA-dependent protein kinase activity and tumor cell radiosensitivity.

1995 • 53 citations

An in vitro Latency System for Herpes Simplex Virus Type 2

1986 • 47 citations

Evaluation of colocalization interactions between the IE110, IE175, and IE63 transactivator proteins of herpes simplex virus within subcellular punctate structures

1995 • 45 citations

A DNA End-Binding Factor Involved in Double-Strand Break Repair and V(D)J Recombination

1994 • 44 citations

Protein kinases and the response to DNA damage

1994 • 36 citations

The Human DNA-Activated Protein Kinase, DNA-PK: Substrate Specificity

1995 • 14 citations

Menage a Trois: Glycogenin, Proteoglycan Core Protein Xylosyltransferase and UDP-xylose.

1995 • 4 citations