Selectin inhibition: synthesis and evaluation of novel sialylated, sulfated and fucosylated oligosaccharides, including the major capping group of GlyCAM-1

Adhesion molecules and inflammatory injury

1994 • 1,023 citations

Selectin ligands.

1994 • 943 citations

Mucin-Type Glycoproteins

1992 • 902 citations

Iodonium ion promoted reactions at the anomeric centre. II An efficient thioglycoside mediated approach toward the formation of 1,2-trans linked glycosides and glycosidic esters

1990 • 822 citations

An endothelial ligand for L-Selectin is a novel mucin-like molecule

1992 • 660 citations

Leukocyte Trafficking Mediated by Selectin-Carbohydrate Interactions

1995 • 648 citations

Binding of L-Selectin to the Vascular Sialomucin CD34

1993 • 629 citations

SELECTIN-CARBOHYDRATE INTERACTIONS AND THE INITIATION OF THE INFLAMMATORY RESPONSE

1995 • 574 citations

L-selectin-mediated lymphocyte rolling on MAdCAM-1

1993 • 540 citations

Identification of a specific glycoprotein ligand for P-selectin (CD62) on myeloid cells.

1992 • 519 citations

A carbohydrate domain common to both sialyl Le(a) and sialyl Le(X) is recognized by the endothelial cell leukocyte adhesion molecule ELAM-1

1991 • 480 citations

The selectins and their ligands

1994 • 478 citations

A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding

1995 • 435 citations

Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains

1994 • 397 citations

AN EFFICIENT METHOD FOR GLUCOSYLATION OF HYDROXY COMPOUNDS USING GLUCOPYRANOSYL FLUORIDE

1981 • 393 citations

PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus

1995 • 383 citations

Post-translational Modifications of Recombinant P-selectin Glycoprotein Ligand-1 Required for Binding to P- and E-selectin

1996 • 340 citations

Identification of a carbohydrate-based endothelial ligand for a lymphocyte homing receptor.

1991 • 308 citations

Structural and functional characterization of monomeric soluble P-selectin and comparison with membrane P-selectin

1993 • 297 citations

Structure of the O-Glycans in GlyCAM-1, an Endothelial-derived Ligand for L-selectin

1995 • 291 citations

Tyrosine Sulfation of P-selectin Glycoprotein Ligand-1 Is Required for High Affinity Binding to P-selectin

1995 • 290 citations

Characterization of a specific ligand for P-selectin on myeloid cells. A minor glycoprotein with sialylated O-linked oligosaccharides

1993 • 274 citations

Sialyl- and fucosyltransferases in the biosynthesis of asparaginyl-linked oligosaccharides in glycoproteins. Mutually exclusive glycosylation by beta-galactoside alpha2 goes to 6 sialyltransferase and N-acetylglucosaminide alpha1 goes to 3 fucosyltransferase

1978 • 256 citations

Biochemistry of carbohydrate‐protein interaction ¹

1992 • 205 citations

Calcium-Dependent Heparin-Like Ligands For L-Selectin in Nonlymphoid Endothelial Cells

1993 • 201 citations

Stereoselective synthesis of 2-thioglycosides of N-acetylneuraminic acid

1989 • 193 citations

6'-Sulfated Sialyl Lewis x Is a Major Capping Group of GlyCAM-1

1994 • 191 citations

An efficient approach to O-glycosides through CuBr2-Bu4NBr mediated activation of glycosides

1986 • 187 citations

Higher-affinity oligosaccharide ligands for E-selectin.

1993 • 166 citations

Identification of an E-selectin region critical for carbohydrate recognition and cell adhesion [published erratum appears in J Cell Biol 1993 Feb;120(4):1071]

1992 • 166 citations

Structure--function studies on selectin carbohydrate ligands. Modifications to fucose, sialic acid and sulphate as a sialic acid replacement

1993 • 164 citations

Role of selectins, a new family of adhesion molecules, in ischaemia-reperfusion injury

1994 • 154 citations

Peptides Which Bind to E-selectin and Block Neutrophil Adhesion

1995 • 153 citations

P- and E-selectin use common sites for carbohydrate ligand recognition and cell adhesion.

1993 • 150 citations

Sulfated blood group Lewis(a). A superior oligosaccharide ligand for human E-selectin.

1994 • 145 citations

Sialylation and sulfation of the carbohydrate chains in respiratory mucins from a patient with cystic fibrosis.

1994 • 144 citations

Ligand Recognition by E-Selectin: Synthesis, Inhibitory Activity and Conformational Analysis of Bivalent Sialyl Lewis x Analogs

1995 • 135 citations

Defined geometry of binding between triantennary glycopeptide and the asialoglycoprotein receptor of rat heptocytes.

1990 • 128 citations

Monosialogangliosides of Human Myelogenous Leukemia HL60 Cells and Normal Human Leukocytes. 2. Characterization of E-Selectin Binding Fractions, and Structural Requirements for Physiological Binding to E-Selectin

1996 • 112 citations

Calcium-dependent oligonucleotide antagonists specific for L-selectin.

1996 • 110 citations

Total synthesis of sialyl dimeric Lex

1992 • 110 citations

Sialyl Lewis X mimics derived from a pharmacophore search are selectin inhibitors with anti-inflammatory activity.

1994 • 102 citations

De novo expression of endothelial sialyl Lewis(a) and sialyl Lewis(x) during cardiac transplant rejection: superior capacity of a tetravalent sialyl Lewis(x) oligosaccharide in inhibiting L-selectin-dependent lymphocyte adhesion.

1995 • 101 citations

The GDP-fucose:N-acetylglucosaminide 3-alpha-L-fucosyltransferases of LEC11 and LEC12 Chinese hamster ovary mutants exhibit novel specificities for glycolipid substrates.

1987 • 98 citations

Binding of Sialyl Lewis X to E-Selectin As Measured by Fluorescence Polarization

1995 • 79 citations

Isolation and Characterization of Natural Protein-Associated Carbohydrate Ligands for E-Selectin

1994 • 78 citations

Further characterization of the interaction between L-selectin and its endothelial ligands

1992 • 76 citations

Characterization of human platelet GMP-140 as a heparin-binding protein

1989 • 75 citations

Oligosaccharide structures of mucins secreted by the human colonic cancer cell line CL.16E.

1992 • 75 citations

Enhanced interaction of L-selectin with the high endothelial venule ligand via selectively oxidized sialic acids.

1993 • 73 citations

Multivalent sialyl-LeX: potent inhibitors of E-selectin-mediated cell adhesion; reagent for staining activated endothelial cells

1994 • 73 citations

The soluble form of E-selectin is an asymmetric monomer. Expression, purification, and characterization of the recombinant protein.

1994 • 72 citations

Enzymatic synthesis of a 6′-sulphated sialyl-Lewis^x which is an inhibitor of L-selectin binding to peripheral addressin

1994 • 70 citations

Synthesis of a Divalent Sialyl Lewis x O‐glycan, a Potent Inhibitor of Lymphocyte‐Endothelium Adhesion

1995 • 67 citations

Interaction of P-selectin (CD62) and its cellular ligand: Analysis of critical residues

1993 • 66 citations

Selective modulation of the expression of L-selectin ligands by an immune response

1995 • 62 citations

Interterminal distance and flexibility of a triantennary glycopeptide as measured by resonance energy transfer

1991 • 57 citations

Sulfated disaccharide with greater inhibitory potency for L-selectin than sialyl Lewis x

1995 • 57 citations

Subsets of sialylated, sulfated mucins of diverse origins are recognized by L-selectin. Lack of evidence for unique oligosaccharide sequences mediating binding

1996 • 55 citations

Biosynthesis of GlyCAM-1, a Mucin-like Ligand for L-Selectin

1995 • 51 citations

Characterization of a novel mucin sulphotransferase activity synthesizing sulphated O-glycan core 1, 3-sulphate-Galβ1-3GalNAcα-R

1995 • 50 citations

The convergence‐divergence duality in lectin domains of selectin family and its implications

1995 • 47 citations

Selectin-Saccharide Interactions: Revealing Structure-Function Relationships with Chemical Synthesis

1995 • 45 citations

Synthesis of a dimeric Lewis X hexasaccharide derivative corresponding to a tumor-associated glycolipid

1988 • 44 citations

Purification and characterization of GDP-L-Fuc-N-acetyl-beta-D-glucosaminide alpha 1—-3fucosyltransferase from human neuroblastoma cells. Unusual substrate specificities of the tumor enzyme

1991 • 42 citations

The glycoprotease of Pasteurella haemolytica A1 eliminates binding of myeloid cells to P-selectin but not to E-selectin

1992 • 42 citations

Direct demonstration of heterogeneous, sulfatedO-linked carbohydrate chains on an endothelial ligand for L-selectin

1993 • 40 citations

Myeloglycan, a Series of E-Selectin-Binding Polylactosaminolipids Found in Normal Human Leukocytes and Myelocytic Leukemia HL60 Cells

1995 • 38 citations

Structural analysis of monosulfated side-chain oligosaccharides isolated from human tracheobronchial mucous glycoproteins

1992 • 37 citations

ChemInform Abstract: THE PROPERTIES OF A ′SYNTHETIC′ ANTIGEN RELATED TO THE HUMAN BLOOD-GROUP LEWIS A

1975 • 35 citations

Synthesis of methyl O-(3-deoxy-3-fluoro-β-d-galactopyranosyl)-(1→6)-O-β-d-galactopyranosyl-(1→6)-3-deoxy-3-fluoro -β-d-galactopyranoside and related n.m.r. studies

1985 • 23 citations

Recognition of consensus CHO structure in ligands for selectins by novel antibody against sialyl Lewis X

1995 • 22 citations

First synthesis of the 3′-sulfated Lewis trisaccharide, putative ligand for the leucocyte homing receptor

1993 • 22 citations

Synthesis of the sodium salts of methyl 2-O-α-l-fucopyranosyl-α-l-fucopyranoside 3- and 4-sulfate

1990 • 20 citations

Selectin ligands: 2,3,4-tri-O-acetyl-6-O-pivaloyl-α/β-galactopyranosyl halide as novel glycosyl donor for the synthesis of 3-O-sialyl or 3-O-sulfo Le^xand Le^atype structures

1996 • 20 citations

A liquid‐phase binding analysis for L‐selectin

1994 • 19 citations