Postischemic myocardial "stunning". Identification of major differences between the open-chest and the conscious dog and evaluation of the oxygen radical hypothesis in the conscious dog.

[13] Catalase in vitro

1984 • 22,648 citations

Superoxide Dismutase

1969 • 12,578 citations

Statistical Methods in Medical Research.

1972 • 4,731 citations

The stunned myocardium: prolonged, postischemic ventricular dysfunction.

1982 • 2,825 citations

Demonstration of free radical generation in "stunned" myocardium of intact dogs with the use of the spin trap alpha-phenyl N-tert-butyl nitrone.

1988 • 691 citations

Marked reduction of free radical generation and contractile dysfunction by antioxidant therapy begun at the time of reperfusion. Evidence that myocardial "stunning" is a manifestation of reperfusion injury.

1989 • 580 citations

Direct evidence that oxygen-derived free radicals contribute to postischemic myocardial dysfunction in the intact dog.

1989 • 467 citations

Cardiovascular Control Mechanisms in the Conscious State

1975 • 387 citations

Superoxide dismutase plus catalase improve contractile function in the canine model of the "stunned myocardium".

1986 • 360 citations

The three-dimensional dynamic geometry of the left ventricle in the conscious dog.

1976 • 343 citations

Enhancement of recovery of myocardial function by oxygen free-radical scavengers after reversible regional ischemia.

1985 • 324 citations

Time course and determinants of recovery of function after reversible ischemia in conscious dogs

1988 • 218 citations

Beneficial actions of superoxide dismutase and catalase in stunned myocardium of dogs

1986 • 205 citations

Effects of sodium pentobarbital anesthesia on left ventricular function and distribution of cardiac output in dogs, with particular reference to the mechanism for tachycardia.

1976 • 184 citations

Attenuation of dysfunction in the postischemic 'stunned' myocardium by dimethylthiourea.

1987 • 168 citations

Regional Myocardial Blood Flow in Awake Dogs

1974 • 161 citations

Human Cu/Zn superoxide dismutase cDNA: isolation of clones synthesising high levels of active or inactive enzyme from an expression library

1985 • 149 citations

Prolonged abnormalities of left ventricular diastolic wall thinning in the “stunned” myocardium in conscious dogs: Time course and relation to systolic function

1989 • 134 citations

The iron chelator desferrioxamine attenuates postischemic ventricular dysfunction

1987 • 133 citations

N-2-Mercaptopropionylglycine improves recovery of myocardial function after reversible regional ischemia

1986 • 115 citations

Effects of anesthesia and sleep on circulatory response to carotid sinus nerve stimulation

1971 • 109 citations

Evidence for a role of iron-catalyzed oxidants in functional and metabolic stunning in the canine heart.

1988 • 98 citations

Oxygen consumption and coronary reactivity in postischemic myocardium.

1989 • 97 citations

Evidence for a pathogenetic role of xanthine oxidase in the "stunned" myocardium

1987 • 93 citations

Nonuniform transmural recovery of contractile function in stunned myocardium

1989 • 79 citations

Iron-mediated radical reactions upon reperfusion contribute to myocardial "stunning"

1990 • 77 citations

Time course of recovery of “stunned” myocardium following variable periods of ischemia in conscious and anesthetized dogs

1987 • 75 citations

Effects of cardiac depression and of anesthesia on the myocardial action of a cardiac glycoside

1971 • 73 citations

Influence of neutrophil depletion on myocardial function and flow after reversible ischemia

1989 • 68 citations

Effect of superoxide dismutase and catalase, given separately, on myocardial "stunning"

1990 • 63 citations

Influence of acute myocardial depression on left ventricular stiffness and its elastic and viscous components.

1975 • 40 citations

Disparity of reperfusion arrhythmias after reversible myocardial ischemia in open chest and conscious dogs

1986 • 27 citations

Is “stunned myocardium” a protective mechanism? Effect of acute recruitment and acute β-blockade on recovery of contractile function and high-energy phosphate stores at 1 day post-reperfusion

1989 • 24 citations

Lipoxygenase inhibitor nafazatrom fails to attenuate postischaemic ventricular dysfunction

1987 • 23 citations

Different Relations Between Infarct Size and Occluded Bed Size in Barbiturate-Anesthetized Versus Conscious Dogs

1985 • 23 citations

Ejection- and isovolumic contraction-phase wall thickening in nonischemic myocardium during coronary occlusion

1990 • 17 citations

Beneficial effects of oxypurinol pretreatment in stunned, reperfused canine myocardium

1989 • 8 citations