Molecular evolution of the vertebrate immune system

The neighbor-joining method: a new method for reconstructing phylogenetic trees.

1987 • 59,130 citations

The Neutral Theory of Molecular Evolution

1979 • 7,965 citations

The Neutral Theory of Molecular Evolution

1983 • 6,141 citations

Evolution by Gene Duplication

1970 • 6,000 citations

Evolution by gene duplication

1970 • 5,849 citations

Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions.

1986 • 4,940 citations

Structure of the human class I histocompatibility antigen, HLA-A2

1987 • 3,453 citations

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

1987 • 2,403 citations

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection

1988 • 1,968 citations

Vertebrate Paleontology and Evolution

1988 • 1,723 citations

MHC ligands and peptide motifs: first listing

1995 • 1,674 citations

A Simple Method for Estimating and Testing Minimum-Evolution Trees

1992 • 1,471 citations

Natural history of the major histo-compatibility complex

1987 • 1,274 citations

Structural Analysis of Substrate Binding by the Molecular Chaperone DnaK

1996 • 1,247 citations

The evolution of functionally novel proteins after gene duplication

1994 • 974 citations

Gene duplications and the origins of vertebrate development

1994 • 951 citations

Nucleotide substitution at major histocompatibility complex class II loci: evidence for overdominant selection.

1989 • 893 citations

Assembly, Transport, and Function of MHC Class II Molecules

1994 • 791 citations

Enhanced immunological surveillance in mice heterozygous at the H-2 gene complex

1975 • 751 citations

Vertebrate paleontology and evolution

1988 • 749 citations

Population Biology of Antigen Presentation by MHC Class I Molecules

1996 • 652 citations

Mediation by HLA-DM of dissociation of peptides from HLA-DR

1995 • 555 citations

Evolution of the Vertebrate Genome as Reflected in Paralogous Chromosomal Regions in Man and the House Mouse

1993 • 475 citations

The natural history of the major histocompatibility complex

1987 • 468 citations

The multicatalytic proteinase complex, a major extralysosomal proteolytic system

1990 • 464 citations

T cell antigen receptors and the immunoglobulin supergene family

1985 • 453 citations

A molecular model of MHC class-I-restricted antigen processing

1992 • 438 citations

Ancient Linkage Groups and Frozen Accidents

1973 • 338 citations

Variances of the average numbers of nucleotide substitutions within and between populations.

1989 • 332 citations

Somatic hypermutation

1995 • 248 citations

Isolation of carp genes encoding major histocompatibility complex antigens.

1990 • 238 citations

Evolution of the major histocompatibility complex: independent origin of nonclassical class I genes in different groups of mammals.

1989 • 228 citations

Divergent evolution and evolution by the birth-and-death process in the immunoglobulin VH gene family.

1994 • 222 citations

Positive darwinian selection observed at the variable-region genes of immunoglobulins.

1989 • 206 citations

Sequence of rat liver alpha 2-macroglobulin and acute phase control of its messenger RNA.

1987 • 182 citations

Structure, Organization, and Regulation of the Complement Genes

1988 • 178 citations

Chromosomal localization of the proteasome Z subunit gene reveals an ancient chromosomal duplication involving the major histocompatibility complex.

1996 • 172 citations

Characterization of amalgam: A member of the immunoglobulin superfamily from Drosophila

1988 • 164 citations

Phylogenetic diversification of immunoglobulin genes and the antibody repertoire.

1993 • 159 citations

Proteasome components with reciprocal expression to that of the MHC-encoded LMP proteins

1994 • 157 citations

rpt-1, an intracellular protein from helper/inducer T cells that regulates gene expression of interleukin 2 receptor and human immunodeficiency virus type 1.

1988 • 150 citations

Which came first, MHC class I or class II?

1991 • 132 citations

Primordial emergence of the recombination activating gene 1 (RAG1): sequence of the complete shark gene indicates homology to microbial integrases.

1996 • 125 citations

GENETIC VARIABILITY MAINTAINED BY MUTATION AND OVERDOMINANT SELECTION IN FINITE POPULATIONS

1981 • 125 citations

Isolation of a hagfish gene that encodes a complement component.

1992 • 119 citations

Complete complementary DNA sequence of the third component of complement of lamprey. Implication for the evolution of thioester containing proteins.

1992 • 116 citations

Molecular cloning of RAD16, a gene involved in differential repair inSaccharomyces cerevisiae

1992 • 108 citations

Evolutionary relationships of class II major-histocompatibility-complex genes in mammals.

1990 • 101 citations

Coordinated Amino Acid Changes in the Evolution of Mammalian Defensins

1997 • 85 citations

The conundrum of nonclassical major histocompatibility complex genes.

1994 • 79 citations

The evolution of the type I interferon gene family in mammals

1995 • 68 citations

Molecular evolution of the vertebrate immune system.

1994 • 63 citations

Evolutionary relationships of the classes of major histocompatibility complex genes

1993 • 62 citations

Cloning of a New "Finger" Protein Gene (ZNF173) within the Class I Region of the Human MHC

1995 • 56 citations

A controlled breakdown: Antigen processing and the turnover of viral proteins

1992 • 54 citations

Sequence and diversity of rhesus monkey T-cell receptor ? chain genes

1992 • 51 citations

Evolution of V genes: DNA sequence structure of functional germline genes and pseudogenes

1995 • 47 citations

Evolution of the proteasome components

1997 • 46 citations

Evolution of the ATP-binding-cassette transmembrane transporters of vertebrates.

1994 • 45 citations

Invertebrate Immunology

1996 • 45 citations

Phylogeny of the C3/C4/C5 complement-component gene family indicates that C5 diverged first.

1994 • 39 citations

CTX, a new lymphocyte receptor in Xenopus,, and the early evolution of Ig domains

1996 • 38 citations

Gene duplication and recombination in the evolution of mammalian Fc receptors

1996 • 20 citations

Structural superfamilies of the complement system.

1988 • 16 citations